Mimicking 3D breast tumor-stromal interactions to screen novel cancer therapeutics.

[1]  A. Jemal,et al.  Cancer statistics, 2022 , 2022, CA: a cancer journal for clinicians.

[2]  John C. Dawson,et al.  MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity , 2021, Nature Methods.

[3]  T. Sharif,et al.  The Breast Tumor Microenvironment: A Key Player in Metastatic Spread , 2021, Cancers.

[4]  G. Tse,et al.  Tumor Microenvironment in Breast Cancer—Updates on Therapeutic Implications and Pathologic Assessment , 2021, Cancers.

[5]  B. Nielsen,et al.  Monocyte Infiltration and Differentiation in 3D Multicellular Spheroid Cancer Models , 2021, Pathogens.

[6]  N. Bernardes,et al.  p28-functionalized PLGA nanoparticles loaded with gefitinib reduce tumor burden and metastases formation on lung cancer. , 2021, Journal of controlled release : official journal of the Controlled Release Society.

[7]  P. Gascón,et al.  Cancer-Associated Fibroblasts in Breast Cancer Treatment Response and Metastasis , 2021, Cancers.

[8]  Xuelei Ma,et al.  The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment , 2021, Frontiers in Cell and Developmental Biology.

[9]  Smriti Singh,et al.  3-D vascularized breast cancer model to study the role of osteoblast in formation of a pre-metastatic niche , 2021, Scientific Reports.

[10]  M. Vicent,et al.  The past, present, and future of breast cancer models for nanomedicine development , 2021, Advanced drug delivery reviews.

[11]  Ruhong Li,et al.  Cancer-associated fibroblasts: overview, progress, challenges, and directions , 2021, Cancer Gene Therapy.

[12]  C. Barrias,et al.  Engineering a Vascularized 3D Hybrid System to Model Tumor-Stroma Interactions in Breast Cancer , 2021, Frontiers in Bioengineering and Biotechnology.

[13]  K. Kim,et al.  Challenges of applying multicellular tumor spheroids in preclinical phase , 2021, Cancer cell international.

[14]  N. Wani,et al.  Tumor microenvironment promotes breast cancer chemoresistance , 2021, Cancer Chemotherapy and Pharmacology.

[15]  Ana C. Henriques,et al.  Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research , 2020, Pharmaceutics.

[16]  J. Merlin,et al.  Advanced co-culture 3D breast cancer model for investigation of fibrosis induced by external stimuli: optimization study , 2020, Scientific Reports.

[17]  Gang Li,et al.  Paclitaxel inhibits proliferation and invasion and promotes apoptosis of breast cancer cells by blocking activation of the PI3K/AKT signaling pathway. , 2020, Advances in clinical and experimental medicine : official organ Wroclaw Medical University.

[18]  W. N. Ibrahim,et al.  Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells , 2020, International journal of nanomedicine.

[19]  A. Tesei,et al.  Modeling neoplastic disease with spheroids and organoids , 2020, Journal of Hematology & Oncology.

[20]  H. Santos,et al.  Colorectal cancer triple co-culture spheroid model to assess the biocompatibility and anticancer properties of polymeric nanoparticles. , 2020, Journal of controlled release : official journal of the Controlled Release Society.

[21]  A. Richardson,et al.  Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages , 2020, Nature Communications.

[22]  Xiang Ren,et al.  Breast cancer models: Engineering the tumor microenvironment. , 2020, Acta biomaterialia.

[23]  Thea D. Tlsty,et al.  A framework for advancing our understanding of cancer-associated fibroblasts , 2020, Nature Reviews Cancer.

[24]  Delong Jiao,et al.  Necroptosis, tumor necrosis and tumorigenesis , 2019, Cell stress.

[25]  I. Meinhold-Heerlein,et al.  Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials , 2019, Cancers.

[26]  H. Tavana,et al.  Fibroblasts Promote Proliferation and Matrix Invasion of Breast Cancer Cells in Co‐Culture Models , 2019, Advanced Therapeutics.

[27]  P. Gellert,et al.  Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids. , 2019, Bioconjugate chemistry.

[28]  P. Spellman,et al.  Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets , 2019, Cancer cell.

[29]  Ellen M. Langer,et al.  Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting , 2019, Cell reports.

[30]  S. Kwon,et al.  Tumor-Associated Macrophages as Potential Prognostic Biomarkers of Invasive Breast Cancer , 2019, Journal of breast cancer.

[31]  J. Jonkers,et al.  Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment , 2018, Cancer and Metastasis Reviews.

[32]  Dongjin Lee,et al.  The Combined Effects of Co-Culture and Substrate Mechanics on 3D Tumor Spheroid Formation within Microgels Prepared via Flow-Focusing Microfluidic Fabrication , 2018, Pharmaceutics.

[33]  Christian D. Ahrberg,et al.  Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening , 2018, Scientific Reports.

[34]  E. D. de Vries,et al.  Tumor-associated macrophages in breast cancer: Innocent bystander or important player? , 2018, Cancer treatment reviews.

[35]  Jun Li,et al.  Three-dimensional tumor model mimics stromal – breast cancer cells signaling , 2017, Oncotarget.

[36]  M. Gomez-Lazaro,et al.  Pro-inflammatory chitosan/poly(γ-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity. , 2017, Acta biomaterialia.

[37]  A. Grabowska,et al.  In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization , 2017, SLAS discovery : advancing life sciences R & D.

[38]  Daniel S. Reynolds,et al.  Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment , 2017, Scientific Reports.

[39]  Amitava Das,et al.  Inhibiting epidermal growth factor receptor signalling potentiates mesenchymal–epithelial transition of breast cancer stem cells and their responsiveness to anticancer drugs , 2017, The FEBS journal.

[40]  Vítor M Gaspar,et al.  3D tumor spheroids: an overview on the tools and techniques used for their analysis. , 2016, Biotechnology advances.

[41]  Kristina Stumpf,et al.  Tumor-associated stromal cells as key contributors to the tumor microenvironment , 2016, Breast Cancer Research.

[42]  S. Pedersen,et al.  Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment , 2016, Molecular Cancer.

[43]  A. Nüssler,et al.  Differentiation of human CD14+ monocytes: an experimental investigation of the optimal culture medium and evidence of a lack of differentiation along the endothelial line , 2016, Experimental & Molecular Medicine.

[44]  S. Elmore,et al.  Recommendations from the INHAND Apoptosis/Necrosis Working Group , 2016, Toxicologic pathology.

[45]  J. Pourchez,et al.  Electrostatic interactions favor the binding of positive nanoparticles on cells: A reductive theory , 2015 .

[46]  A. Tzankov,et al.  Role of the Tumor Microenvironment in Breast Cancer , 2015, Pathobiology.

[47]  Shuichi Takayama,et al.  Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays. , 2015, Gynecologic oncology.

[48]  Marius Raica,et al.  The Story of MCF-7 Breast Cancer Cell Line: 40 years of Experience in Research. , 2015, Anticancer research.

[49]  Brian Ruffell,et al.  Macrophages and therapeutic resistance in cancer. , 2015, Cancer cell.

[50]  Yang Zhang,et al.  Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance in MCF-7 breast cancer cells by inducing ERα re-expression , 2015, Scientific Reports.

[51]  L. weiswald,et al.  Spherical Cancer Models in Tumor Biology1 , 2015, Neoplasia.

[52]  Timothy Marsh,et al.  Fibroblasts as architects of cancer pathogenesis. , 2013, Biochimica et biophysica acta.

[53]  Hiroko Masuda,et al.  Role of epidermal growth factor receptor in breast cancer , 2012, Breast Cancer Research and Treatment.

[54]  Raimo Hartmann,et al.  Quantification of the internalization patterns of superparamagnetic iron oxide nanoparticles with opposite charge , 2012, Journal of Nanobiotechnology.

[55]  K. Midwood,et al.  Plasma and cellular fibronectin: distinct and independent functions during tissue repair , 2011, Fibrogenesis & tissue repair.

[56]  V. Valero,et al.  Phase II, Randomized Trial to Compare Anastrozole Combined with Gefitinib or Placebo in Postmenopausal Women with Hormone Receptor–Positive Metastatic Breast Cancer , 2010, Clinical Cancer Research.

[57]  Charles M Perou,et al.  EGFR associated expression profiles vary with breast tumor subtype , 2007, BMC Genomics.

[58]  John Condeelis,et al.  Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis , 2006, Cell.

[59]  A. del Giglio,et al.  Gefitinib (Iressa) in metastatic patients with non-small cell lung cancer: preliminary experience in a Brazilian center. , 2004, Sao Paulo medical journal = Revista paulista de medicina.

[60]  R. Nicholson,et al.  The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro. , 2003, Endocrinology.

[61]  R. Pazdur,et al.  FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. , 2003, The oncologist.

[62]  Hee Jun Choi,et al.  EGFR is a Therapeutic Target in Hormone Receptor-Positive Breast Cancer. , 2019, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

[63]  Valerie Speirs,et al.  Current and Emerging 3D Models to Study Breast Cancer. , 2019, Advances in experimental medicine and biology.

[64]  B. Godin,et al.  3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method. , 2016, Methods in molecular biology.