in a mouse model of pulmonary inflammation Impaired exercise capacity and skeletal muscle function

Summary of Major Findings In this study of a lifelong pulmonary inflammation mousemodel, circulating TNF reached very high levels in the lungand circulation similarly in both male and female mice. How-ever, exercise limitation was selectively impaired only in maleSP-C/TNF mice. Changes in the SP-C/TNF mouse pheno-type that could contribute to this exercise limitation and whichwerefoundtobeselectivelyalteredinmalemiceareadecreasein overall body weight, skeletal muscle atrophy, and an im-paired muscle oxidative phenotype that was accompanied byincreased TNF, MurF1, and atrogin1 and reduced PGC-1 expression. Reduced Body Weight and Loss of the Oxidative MusclePhenotype A prominent change that occurred only in male SP-C/TNF mice was an up to 23% lower body weight. Total Fig. 4. Activity, food and water intake, andoxygen uptake in cage-confined male SP-C/TNF and WT mice. Mice were monitored inseparate cages for changes in total activity ( A ),respiratory exchange ratio (RER) ( B ), rate ofoxygen uptake (V˙

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