Biotechnology - A Perspective

Biotechnology is a diverse enterprise that captured the imagination of the general public in the last quarter of the 20th century.i¾ i¾ The announcement of the rough draft of the human genome at the beginning of the 21st century may prove to be one of the greatest steps in the development of mankind.i¾ i¾ For this potential to be fully realized, many technical barriers must be overcome.i¾ i¾ This perspective identifies and briefly discusses the major scientific areas that contributed to the foundations of biotechnology.i¾ i¾ This is not a complete historical account of the scientific advancements that were hallmarks of progress in the field.i¾ i¾ But, key contributions are noted to give the reader some feeling for the rapidity with which biotechnology is evolving.i¾ i¾ Now is an exciting time to be involved in biological research.i¾ i¾ Hopefully, this perspective will convey some of that excitement felt by the scientific community over the future of biotechnology.

[1]  M. Seldin Toward functional genomics. , 1997, Methods.

[2]  S. Brenner,et al.  Theoretical biology in the third millennium. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[3]  E. Winzeler,et al.  Genomics, gene expression and DNA arrays , 2000, Nature.

[4]  J. Lindon,et al.  'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.

[5]  A. D. Kaiser,et al.  Enzymatic end-to end joining of DNA molecules. , 1973, Journal of molecular biology.

[6]  G. Vogel Harnessing the Power of Stem Cells , 1999, Science.

[7]  S. Ferber Can we create new organs from our own tissues? , 2000, The Israel Medical Association journal : IMAJ.

[8]  S. Rand Bioinstrumentation measurements versus clinical grading scales. , 1998, Journal of the American Academy of Dermatology.

[9]  E. Snyder,et al.  The possibilities/perplexities of stem cells , 2000, Nature Biotechnology.

[10]  I. Anegon,et al.  Gene therapy in transplantation in the year 2000: moving towards clinical applications? , 2000, Gene Therapy.

[11]  C. Sander,et al.  Yeast chromosome III: new gene functions. , 1994, The EMBO journal.

[12]  M. Mann,et al.  Proteomics to study genes and genomes , 2000, Nature.

[13]  J. M. Prober,et al.  A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides. , 1987, Science.

[14]  D. Ferber Lab-Grown Organs Begin to Take Shape , 1999, Science.

[15]  J E Bailey,et al.  Mathematical Modeling and Analysis in Biochemical Engineering: Past Accomplishments and Future Opportunities , 1998, Biotechnology progress.

[16]  B. Dujon,et al.  The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. , 1997, Nature.

[17]  G. Gil,et al.  A biosensor for the detection of gas toxicity using a recombinant bioluminescent bacterium. , 2000, Biosensors & bioelectronics.

[18]  L. Hsu,et al.  Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Symons,et al.  Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Trosko Cloning of human stem cells: some broad scientific and philosophical issues. , 2000, The Journal of laboratory and clinical medicine.

[21]  F. Sanger,et al.  DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[22]  W. Szybalski,et al.  Genetics of human cess line. IV. DNA-mediated heritable transformation of a biochemical trait. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[23]  C. Milstein,et al.  Continuous cultures of fused cells secreting antibody of predefined specificity , 1975, Nature.

[24]  K R Rogers,et al.  Principles of affinity-based biosensors , 2000, Molecular biotechnology.

[25]  T K Attwood,et al.  The quest to deduce protein function from sequence: the role of pattern databases. , 2000, The international journal of biochemistry & cell biology.

[26]  R. Durbin,et al.  2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans , 1994, Nature.

[27]  Laxminarayan Sn Biomedicine in the 21st century: impact of information technology. , 1999 .

[28]  M. Hilleman Vaccines in historic evolution and perspective: a narrative of vaccine discoveries. , 2000, Vaccine.

[29]  W. Tolbert,et al.  The large-scale cultivation of mammalian cells. , 1983, Scientific American.

[30]  J M Laval,et al.  Nanobiotechnology and its role in the development of new analytical devices. , 2000, The Analyst.

[31]  Andrew Smith Genome sequence of the nematode C-elegans: A platform for investigating biology , 1998 .

[32]  R. Sommer,et al.  Evolutionary change in the functional specificity of genes. , 1999, Trends in genetics : TIG.

[33]  E. D. Hyman A new method of sequencing DNA. , 1988, Analytical biochemistry.

[34]  N. Reame,et al.  Making babies in the 21st century: new strategies, old dilemmas. , 2000, Women's health issues : official publication of the Jacobs Institute of Women's Health.

[35]  B. Dujon,et al.  The complete DNA sequence of yeast chromosome III , 1992, Nature.

[36]  J. Birch,et al.  Large-scale cell culture in biotechnology. , 1986, Science.

[37]  E Pennisi,et al.  The Human Genome , 2001, Science.

[38]  L. Ilag,et al.  Functional genomics with protein-protein interactions. , 2000, Biotechnology annual review.

[39]  M. Sarikaya,et al.  An introduction to biomimetics: A structural viewpoint , 1994, Microscopy research and technique.

[40]  R. Palmiter,et al.  Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs , 1981, Cell.

[41]  J. Polkinghorne,et al.  Ethical issues in biotechnology. , 2000, Trends in biotechnology.

[42]  K. Mullis,et al.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. , 1988, Science.

[43]  W. N. Burnette,et al.  "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. , 1981, Analytical biochemistry.

[44]  H A Scheraga,et al.  CONFORMATIONAL ENERGY CALCULATIONS OF ENZYME‐SUBSTRATE INTERACTIONS. II. Computation of the Binding Energy for Substrates in the Active Site of α‐Chymotrypsin , 2009 .

[45]  E. Tahvanainen Development of Molecular Genetics , 1999, Clinical chemistry and laboratory medicine.

[46]  E. Southern Detection of specific sequences among DNA fragments separated by gel electrophoresis. , 1975, Journal of molecular biology.

[47]  P Berg,et al.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. , 1982, Journal of molecular and applied genetics.

[48]  J. Murray,et al.  Genetic modification of animals in the next century. , 1999, Theriogenology.

[49]  Edward N. Trifonov,et al.  Earliest pages of bioinformatics , 2000, Bioinform..

[50]  B Schulze,et al.  Biocatalysis for industrial production of fine chemicals. , 1999, Current opinion in biotechnology.

[51]  R. Fleischmann,et al.  Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. , 1995, Science.

[52]  E Marshall,et al.  Gene Therapy Death Prompts Review of Adenovirus Vector , 1999, Science.

[53]  P. Seeburg,et al.  Synthesis of growth hormone by bacteria , 1978, Nature.

[54]  P. Robbins,et al.  Gene therapy in transplantation , 1999, Gene Therapy.

[55]  M. Penttilä,et al.  Recombinant brewer's yeast strains suitable for accelerated brewing. , 1990, Journal of biotechnology.

[56]  David J. Werrett,et al.  Forensic application of DNA ‘fingerprints’ , 1985, Nature.

[57]  E. Pennisi After Dolly, a Pharming Frenzy , 1998, Science.

[58]  E. Pennisi Finally, the Book of Life and Instructions for Navigating It , 2000, Science.

[59]  G. H. Hamm,et al.  The EMBL data library , 1993, Nucleic Acids Res..

[60]  B D Hall,et al.  Synthesis and assembly of hepatitis B virus surface antigen particles in yeast , 1982, Nature.

[61]  E. Pennisi,et al.  Will Dolly Send in the Clones? , 1997, Science.

[62]  Stu Borman PROTEOMICS: Taking Over Where Genomics Leaves Off: Researchers use a variety of tools to prove protein function and interactions, with drug discovery the major goal , 2000 .

[63]  P. C. Steptoe,et al.  BIRTH AFTER THE REIMPLANTATION OF A HUMAN EMBRYO , 1978, The Lancet.

[64]  J. E. Celis,et al.  Two-dimensional gel electrophoresis of proteins : methods and applications , 1984 .