Gene clustering in plant specialized metabolism.

[1]  Regulation of Fungal Elicitors in Plant Secondary Metabolism , 1993 .

[2]  M Frey,et al.  Analysis of a chemical plant defense mechanism in grasses. , 1997, Science.

[3]  F. Lottspeich,et al.  Two glucosyltransferases are involved in detoxification of benzoxazinoids in maize. , 2002, The Plant journal : for cell and molecular biology.

[4]  H. Iwamura,et al.  Molecular characterization and chromosomal localization of cytochrome P450 genes involved in the biosynthesis of cyclic hydroxamic acids in hexaploid wheat , 2002, Molecular Genetics and Genomics.

[5]  H. Iwamura,et al.  Rearrangement of the genes for the biosynthesis of benzoxazinones in the evolution of Triticeae species , 2003, Planta.

[6]  W. Park,et al.  A 2-oxoglutarate-dependent dioxygenase is integrated in DIMBOA-biosynthesis. , 2003, Phytochemistry.

[7]  Reuben J. Peters,et al.  Identification of Syn-Pimara-7,15-Diene Synthase Reveals Functional Clustering of Terpene Synthases Involved in Rice Phytoalexin/Allelochemical Biosynthesis1 , 2004, Plant Physiology.

[8]  A. Osbourn,et al.  A gene cluster for secondary metabolism in oat: implications for the evolution of metabolic diversity in plants. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[9]  John R Carney,et al.  Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes , 2005, Nature Biotechnology.

[10]  T. Kuzuyama,et al.  Elicitor induced activation of the methylerythritol phosphate pathway toward phytoalexins biosynthesis in rice , 2007, Plant Molecular Biology.

[11]  Corinna Lange,et al.  Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. , 2007, Nature chemical biology.

[12]  A. Cyr,et al.  A modular approach for facile biosynthesis of labdane-related diterpenes. , 2007, Journal of the American Chemical Society.

[13]  Kazunori Okada,et al.  Identification of a Biosynthetic Gene Cluster in Rice for Momilactones* , 2007, Journal of Biological Chemistry.

[14]  M. Haslbeck,et al.  Elucidation of the Final Reactions of DIMBOA-Glucoside Biosynthesis in Maize: Characterization of Bx6 and Bx71[W][OA] , 2008, Plant Physiology.

[15]  A. Osbourn,et al.  Metabolic Diversification—Independent Assembly of Operon-Like Gene Clusters in Different Plants , 2008, Science.

[16]  Kazunori Okada,et al.  OsTGAP1, a bZIP Transcription Factor, Coordinately Regulates the Inductive Production of Diterpenoid Phytoalexins in Rice* , 2009, The Journal of Biological Chemistry.

[17]  A. Osbourn,et al.  Cell Type–Specific Chromatin Decondensation of a Metabolic Gene Cluster in Oats[C][W][OA] , 2009, The Plant Cell Online.

[18]  A. Osbourn,et al.  A Serine Carboxypeptidase-Like Acyltransferase Is Required for Synthesis of Antimicrobial Compounds and Disease Resistance in Oats[W][OA] , 2009, The Plant Cell Online.

[19]  Y. Reyes-Domínguez,et al.  Chromatin-level regulation of biosynthetic gene clusters. , 2009, Nature chemical biology.

[20]  K. Ishida,et al.  Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. , 2010, Angewandte Chemie.

[21]  Anne Osbourn,et al.  Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation. , 2010, Trends in genetics : TIG.

[22]  D. Haft,et al.  SMURF: Genomic mapping of fungal secondary metabolite clusters. , 2010, Fungal genetics and biology : FG & B.

[23]  D. Bosch,et al.  Nicotiana benthamiana as a Production Platform for Artemisinin Precursors , 2010, PloS one.

[24]  B. Spitzer-Rimon,et al.  Generation of the potent anti-malarial drug artemisinin in tobacco , 2011, Nature Biotechnology.

[25]  Virginia W Cornish,et al.  Reiterative Recombination for the in vivo assembly of libraries of multigene pathways , 2011, Proceedings of the National Academy of Sciences.

[26]  Anne Osbourn,et al.  From hormones to secondary metabolism: the emergence of metabolic gene clusters in plants. , 2011, The Plant journal : for cell and molecular biology.

[27]  Hans-Wilhelm Nützmann,et al.  Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. , 2011, Angewandte Chemie.

[28]  Tom Ellis,et al.  DNA assembly for synthetic biology: from parts to pathways and beyond. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[29]  Kirsten Jørgensen,et al.  Genomic clustering of cyanogenic glucoside biosynthetic genes aids their identification in Lotus japonicus and suggests the repeated evolution of this chemical defence pathway. , 2011, The Plant journal : for cell and molecular biology.

[30]  Hadi Quesneville,et al.  Formation of plant metabolic gene clusters within dynamic chromosomal regions , 2011, Proceedings of the National Academy of Sciences.

[31]  K. J. McDowall,et al.  The Regulation of the Secondary Metabolism of Streptomyces: New Links and Experimental Advances , 2011 .

[32]  Yansheng Zhang,et al.  The production of artemisinin precursors in tobacco. , 2011, Plant biotechnology journal.

[33]  M. Bibb,et al.  Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters , 2011, Microbial biotechnology.

[34]  C. Hertweck,et al.  Genomics-inspired discovery of natural products. , 2011, Current opinion in chemical biology.

[35]  F. Hilliou,et al.  Phylogenomics of the benzoxazinoid biosynthetic pathway of Poaceae: gene duplications and origin of the Bx cluster , 2012, BMC Evolutionary Biology.

[36]  F. Sato,et al.  A bacterial platform for fermentative production of plant alkaloids , 2011, Nature communications.

[37]  C. Walsh,et al.  Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans , 2011, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Axel A. Brakhage,et al.  Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation , 2011, Proceedings of the National Academy of Sciences.

[39]  Sylvestre Marillonnet,et al.  Generation of families of construct variants using golden gate shuffling. , 2011, Methods in molecular biology.

[40]  S. Brady,et al.  Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites , 2011, Proceedings of the National Academy of Sciences.

[41]  M. Goedbloed,et al.  Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana , 2011, PloS one.

[42]  Peng Xu,et al.  ePathBrick: a synthetic biology platform for engineering metabolic pathways in E. coli. , 2012, ACS synthetic biology.

[43]  Zhen Xie,et al.  Rapid hierarchical assembly of medium-size DNA cassettes , 2012, Nucleic acids research.

[44]  Sylvestre Marillonnet,et al.  Fast track assembly of multigene constructs using Golden Gate cloning and the MoClo system , 2012 .

[45]  C. Smolke,et al.  Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools. , 2012, FEMS yeast research.

[46]  A. Osbourn,et al.  Using a virus-derived system to manipulate plant natural product biosynthetic pathways. , 2012, Methods in enzymology.

[47]  C. Corre,et al.  Waking up Streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors. , 2012, Methods in enzymology.

[48]  K. Ishida,et al.  Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. , 2012, Angewandte Chemie.

[49]  T. Winzer,et al.  A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine , 2012, Science.

[50]  Jay D. Keasling,et al.  Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin , 2012, Proceedings of the National Academy of Sciences.

[51]  A. Osbourn,et al.  Making new molecules - evolution of pathways for novel metabolites in plants. , 2012, Current opinion in plant biology.

[52]  F. Cánovas,et al.  Towards decoding the conifer giga-genome , 2012, Plant Molecular Biology.

[53]  Robert Williams,et al.  Engineering triterpene metabolism in tobacco , 2012, Planta.

[54]  A. Osbourn,et al.  Finding and analyzing plant metabolic gene clusters. , 2012, Methods in enzymology.

[55]  Yisheng Wu,et al.  Characterization of CYP76M5–8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster* , 2012, The Journal of Biological Chemistry.

[56]  J. Keasling,et al.  Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts. , 2012, Metabolic engineering.

[57]  Chan Gao,et al.  Crp Is a Global Regulator of Antibiotic Production in Streptomyces , 2012, mBio.

[58]  Kai Blin,et al.  antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers , 2013, Nucleic Acids Res..

[59]  M. Kolesnikova,et al.  An effective strategy for exploring unknown metabolic pathways by genome mining. , 2013, Journal of the American Chemical Society.

[60]  A. Osbourn,et al.  A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis. , 2013, The New phytologist.

[61]  Kyle R. Conway,et al.  ClusterMine360: a database of microbial PKS/NRPS biosynthesis , 2012, Nucleic Acids Res..

[62]  Douglas G. Scofield,et al.  The Norway spruce genome sequence and conifer genome evolution , 2013, Nature.

[63]  A. Aharoni,et al.  Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes , 2013, Science.

[64]  Anthony M. Bolger,et al.  Evolution of a Complex Locus for Terpene Biosynthesis in Solanum[W][OPEN] , 2013, Plant Cell.

[65]  S. Brady,et al.  Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening , 2013, Proceedings of the National Academy of Sciences.

[66]  A. Osbourn,et al.  Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants , 2013, Proceedings of the National Academy of Sciences.

[67]  J. Keasling,et al.  High-level semi-synthetic production of the potent antimalarial artemisinin , 2013, Nature.

[68]  Shu-Lin Chang,et al.  An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans. , 2013, Journal of the American Chemical Society.

[69]  A. Osbourn,et al.  Modularity of Plant Metabolic Gene Clusters: A Trio of Linked Genes That Are Collectively Required for Acylation of Triterpenes in Oat[W][OA] , 2013, Plant Cell.