Effects of cyclosporine and dexamethasone on canine T cell expression of interleukin-2 and interferon-gamma.

[1]  R. Wills,et al.  Alterations in activated T-cell cytokine expression in healthy dogs over the initial 7 days of twice daily dosing with oral cyclosporine. , 2019, Journal of veterinary pharmacology and therapeutics.

[2]  R. Wills,et al.  Effects of oral cyclosporine on canine T-cell expression of IL-2 and IFN-gamma across a 12-h dosing interval. , 2016, Journal of veterinary pharmacology and therapeutics.

[3]  C. Reinero,et al.  In-vitro immunosuppression of canine T-lymphocyte-specific proliferation with dexamethasone, cyclosporine, and the active metabolites of azathioprine and leflunomide in a flow-cytometric assay. , 2014, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[4]  R. Wills,et al.  Analytical validation of a quantitative reverse transcriptase polymerase chain reaction assay for evaluation of T-cell targeted immunosuppressive therapy in the dog. , 2013, Veterinary immunology and immunopathology.

[5]  C. Gregory,et al.  Outcome after renal transplantation in 26 dogs. , 2012, Veterinary surgery : VS.

[6]  L. Pinchuk,et al.  Pharmacodynamic monitoring of canine T-cell cytokine responses to oral cyclosporine. , 2011, Journal of veterinary internal medicine.

[7]  L. Pinchuk,et al.  Cyclosporine A affects the in vitro expression of T cell activation-related molecules and cytokines in dogs. , 2011, Veterinary immunology and immunopathology.

[8]  D. Kuypers,et al.  New Insights Into the Pharmacokinetics and Pharmacodynamics of the Calcineurin Inhibitors and Mycophenolic Acid: Possible Consequences for Therapeutic Drug Monitoring in Solid Organ Transplantation , 2009, Therapeutic drug monitoring.

[9]  A. Nakao,et al.  Evaluation of interleukin-2 mRNA in whole blood as a parameter for monitoring cyclosporine pharmacodynamics. , 2009, Biological & pharmaceutical bulletin.

[10]  K. Nishifuji,et al.  Cyclosporine A inhibits transcription of cytokine genes and decreases the frequencies of IL-2 producing cells in feline mononuclear cells. , 2008, The Journal of veterinary medical science.

[11]  A. Enk,et al.  Pharmacodynamic immune monitoring of NFAT‐regulated genes predicts skin cancer in elderly long‐term renal transplant recipients , 2008, Clinical transplantation.

[12]  T. Giese,et al.  Ciclosporin A Tapering Monitored by NFAT-Regulated Gene Expression: A New Concept of Individual Immunosuppression , 2008, Transplantation.

[13]  Tetsuro Kobayashi,et al.  Cyclosporine A Inhibits the mRNA Expressions of IL-2, IL-4 and IFN-γ, but not TNF-α, in Canine Mononuclear Cells , 2007 .

[14]  H. Young,et al.  Post-transcriptional control of the interferon system. , 2007, Biochimie.

[15]  J. B. Case,et al.  Incidence of and risk factors for diabetes mellitus in cats that have undergone renal transplantation: 187 cases (1986-2005). , 2007, Journal of the American Veterinary Medical Association.

[16]  K. Budde,et al.  Validation of Immunological Biomarkers for the Pharmacodynamic Monitoring of Immunosuppressive Drugs in Humans , 2007, Therapeutic drug monitoring.

[17]  T. Giese,et al.  Pharmacodynamic Monitoring of Cyclosporine A in Renal Allograft Recipients Shows a Quantitative Relationship Between Immunosuppression and the Occurrence of Recurrent Infections and Malignancies , 2006, Transplantation.

[18]  Frieder Keller,et al.  Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids , 2005, Clinical Pharmacokinetics.

[19]  T. Giese,et al.  Analysis of NFAT-regulated gene expression in vivo: a novel perspective for optimal individualized doses of calcineurin inhibitors. , 2004, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[20]  B. Reitz,et al.  In vitro evaluation of the effects of candidate immunosuppressive drugs: flow cytometry and quantitative real-time PCR as two independent and correlated read-outs. , 2004, Journal of immunological methods.

[21]  L. Madden,et al.  Nonparametric analysis of ordinal data in designed factorial experiments. , 2004, Phytopathology.

[22]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[23]  J. Gummert,et al.  Flow cytometric quantitation of calcium-dependent and -independent mitogen-stimulation of T cell functions in whole blood: inhibition by immunosuppressive drugs in vitro. , 2001, Journal of immunological methods.

[24]  Edgar Brunner,et al.  Nonparametric methods in factorial designs , 2001 .

[25]  C. Gregory,et al.  Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. , 2000, American journal of veterinary research.

[26]  J. Murray,et al.  Inhibition of stimulated interleukin-2 production in whole blood: a practical measure of cyclosporine effect. , 1999, Clinical chemistry.

[27]  W. Jusko,et al.  Species- and gender-related differences in cyclosporine/prednisolone/sirolimus interactions in whole blood lymphocyte proliferation assays. , 1998, The Journal of pharmacology and experimental therapeutics.

[28]  N. Pyszczynski,et al.  Gender-related assessment of cyclosporine/prednisolone/sirolimus interactions in three human lymphocyte proliferation assays. , 1998, Transplantation.

[29]  P. Hogan,et al.  Transcription factors of the NFAT family: regulation and function. , 1997, Annual review of immunology.

[30]  P. Halloran,et al.  Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium. , 1996, Transplantation.

[31]  S. Efrat,et al.  Post-transcriptional Regulation of Human Interleukin-2 Gene Expression at Processing of Precursor Transcripts (*) , 1995, The Journal of Biological Chemistry.

[32]  W. Jusko,et al.  Inhibition of phytohaemagglutinin-induced lymphocyte proliferation by immunosuppressive drugs: use of whole blood culture. , 1994, Immunopharmacology and immunotoxicology.

[33]  S. A. Brown,et al.  Dexamethasone pharmacokinetics in clinically normal dogs during low- and high-dose dexamethasone suppression testing. , 1993, American journal of veterinary research.

[34]  C. Klee,et al.  Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Tsai,et al.  Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. , 1991, The American review of respiratory disease.

[36]  T. Strom,et al.  Abrogation of glucocorticoid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6, and IFN-gamma. , 1991, Journal of immunology.

[37]  T. Rosano,et al.  A comparison of the effects of cyclosporine and steroids on human T lymphocyte responses. , 1988, Transplantation proceedings.

[38]  K. Grabstein,et al.  Expression of interleukin 2, interferon-gamma, and the IL 2 receptor by human peripheral blood lymphocytes. , 1986, Journal of immunology.

[39]  N. Yoshimura,et al.  PHARMACODYNAMIC ASSESSMENT OF THE IN VIVO CYCLOSPORINE EFFECT ON INTERLEUKIN‐2 PRODUCTION BY LYMPHOCYTES IN KIDNEY TRANSPLANT RECIPIENTS , 1985, Transplantation.

[40]  G. H. Reem,et al.  Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes. , 1984, Science.

[41]  S. Arya,et al.  Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA. , 1984, Journal of immunology.

[42]  M. Alvinerie,et al.  Pharmacokinetics of dexamethasone and its effect on adrenal gland function in the dog. , 1983, American journal of veterinary research.

[43]  G. Crabtree,et al.  Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. , 1979, Journal of immunology.