Simulation of the Three-Dimensional Flow of Blood Using a Shear-Thinning Viscoelastic Fluid Model

This paper is concerned with the numerical simulation of a thermodynamically compatible viscoelastic shear-thinning fluid model, particularly well suited to describe the rheological response of blood, under physiological conditions. Numerical simulations are performed in two idealized three-dimensional geometries, a stenosis and a curved vessel, to investigate the combined effects of flow inertia, viscosity and viscoelasticity in these geometries. The aim of this work is to provide new insights into the modeling and simulation of homogeneous rheological models for blood and a basis for further developments in modeling and prediction.

[1]  Tomas Bodnár,et al.  On the shear-thinning and viscoelastic effects of blood flow under various flow rates , 2011, Appl. Math. Comput..

[2]  S Chien,et al.  Theoretical and experimental studies on viscoelastic properties of erythrocyte membrane. , 1978, Biophysical journal.

[3]  T. Bodnár,et al.  Numerical Simulations of Blood Flow in a Stenosed Vessel under Different Flow Rates using a Generalized Oldroyd‐B Model , 2009 .

[4]  S Chien,et al.  Shear-dependent deformation of erythrocytes in rheology of human blood. , 1970, The American journal of physiology.

[5]  T. Bodnár,et al.  Numerical Study of the Significance of the Non-Newtonian Nature of Blood in Steady Flow Through a Stenosed Vessel , 2010 .

[6]  M. Anand,et al.  A SHEAR-THINNING VISCOELASTIC FLUID MODEL FOR DESCRIBING THE FLOW OF BLOOD , 2004 .

[7]  K. R. Rajagopal,et al.  A mathematical model to describe the change in the constitutive character of blood due to platelet activation , 2002 .

[8]  D. Steinman,et al.  Simulation of non-Newtonian blood flow in an end-to-side anastomosis. , 1994, Biorheology.

[9]  R M Hochmuth,et al.  Membrane viscoelasticity. , 1976, Biophysical journal.

[10]  S Chien,et al.  Effects of hematocrit and plasma proteins on human blood rheology at low shear rates. , 1966, Journal of applied physiology.

[11]  K. Rajagopal,et al.  A Model for the Formation and Lysis of Blood Clots , 2006, Pathophysiology of Haemostasis and Thrombosis.

[12]  G. Thurston,et al.  Frequency and shear rate dependence of viscoelasticity of human blood. , 1973, Biorheology.

[13]  Stefan Turek,et al.  A numerical investigation of flows of shear-thinning fluids with applications to blood rheology , 2000 .

[14]  S. Charm,et al.  Viscometry of Human Blood for Shear Rates of 0-100,000 sec−1 , 1965, Nature.

[15]  Nhan Phan-Thien,et al.  Fully developed viscous and viscoelastic flows in curved pipes , 2001, Journal of Fluid Mechanics.

[16]  K. R. Rajagopal,et al.  A Gibbs-potential-based formulation for obtaining the response functions for a class of viscoelastic materials , 2011, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[17]  A. Leuprecht,et al.  Computer Simulation of Non-Newtonian Effects on Blood Flow in Large Arteries , 2001, Computer methods in biomechanics and biomedical engineering.

[18]  D. Quemada,et al.  Rheology of concentrated disperse systems III. General features of the proposed non-newtonian model. Comparison with experimental data , 1978 .

[19]  G. Thurston,et al.  Viscoelasticity of human blood. , 1972, Biophysical journal.

[20]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[21]  A. Jameson,et al.  Numerical solution of the Euler equations by finite volume methods using Runge Kutta time stepping schemes , 1981 .

[22]  Nadir Arada,et al.  Viscosity effects on flows of generalized Newtonian fluids through curved pipes , 2007, Comput. Math. Appl..

[23]  S. Chien,et al.  Blood Viscosity: Influence of Erythrocyte Deformation , 1967, Science.

[24]  F. N. van de Vosse,et al.  The influence of the non-Newtonian properties of blood on the flow in large arteries: steady flow in a carotid bifurcation model. , 1999, Journal of biomechanics.

[25]  T. Bodnár,et al.  Numerical Simulation of the Coagulation Dynamics of Blood , 2008 .

[26]  K. Rajagopal,et al.  A thermodynamic frame work for rate type fluid models , 2000 .

[27]  Jan Vierendeels,et al.  A multigrid semi-implicit line-method for viscous incompressible and low-mach-number flows on high aspect ratio grids , 1999 .

[28]  Kumbakonam R. Rajagopal,et al.  A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood , 2003 .

[29]  T. Bodnár,et al.  Numerical simulation of turbulent free-surface flow in curved channel , 2006 .

[30]  K R Rajagopal,et al.  A model for the formation, growth, and lysis of clots in quiescent plasma. A comparison between the effects of antithrombin III deficiency and protein C deficiency. , 2008, Journal of theoretical biology.

[31]  S Chien,et al.  Blood Viscosity: Influence of Erythrocyte Aggregation , 1967, Science.

[32]  L. Talbot,et al.  Flow in Curved Pipes , 1983 .