Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss
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L. Zon | C. Kaufman | A. Look | Shuning He | S. Rodig | J. Etchin | A. Berezovskaya | E. van Rooijen | M. Mansour | M. Zimmerman | E. Patton | Chang-Bin Jing | Hillary M. Layden | Charles K. Kaufman | Megan W. Martel | Grace Thurston | Mark W. Zimmerman | Ellen van Rooijen
[1] A. Jemal,et al. Cancer statistics, 2020 , 2020, CA: a cancer journal for clinicians.
[2] A. Look,et al. The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells , 2018, Leukemia.
[3] A. Letai,et al. Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax. , 2017, Cancer discovery.
[4] Nancy R. Zhang,et al. Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines. , 2017, Cell reports.
[5] Catherine A. Shang,et al. Whole-genome landscapes of major melanoma subtypes , 2017, Nature.
[6] L. Saal,et al. NF1‐mutated melanoma tumors harbor distinct clinical and biological characteristics , 2017, Molecular oncology.
[7] A. Strasser,et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models , 2016, Nature.
[8] J. McQuade,et al. Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. , 2016, Cancer discovery.
[9] R. Young,et al. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation , 2016, Science.
[10] C. Bourque,et al. Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish , 2016, Nature Communications.
[11] B. Glaser,et al. Abrogation of Autophagy by Chloroquine Alone or in Combination with mTOR Inhibitors Induces Apoptosis in Neuroendocrine Tumor Cells , 2015, Neuroendocrinology.
[12] Arati Sharma,et al. Current State of Animal (Mouse) Modeling in Melanoma Research , 2015, Cancer growth and metastasis.
[13] S. Ariyan,et al. Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas , 2015, Nature Genetics.
[14] Steven J. M. Jones,et al. Genomic Classification of Cutaneous Melanoma , 2015, Cell.
[15] N. Mukherjee,et al. Alternative treatments for melanoma: targeting BCL-2 family members to de-bulk and kill cancer stem cells , 2015, Journal of Investigative Dermatology.
[16] Q. Zhong. Faculty Opinions recommendation of Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. , 2015 .
[17] Eric Legius,et al. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies , 2014, Nature.
[18] N. Haass,et al. Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy , 2014, Pigment cell & melanoma research.
[19] D. Gewirtz,et al. Cytotoxic Autophagy in Cancer Therapy , 2014, International journal of molecular sciences.
[20] A. Alavi,et al. Combined MTOR and autophagy inhibition , 2014, Autophagy.
[21] O. Maertens,et al. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. , 2014, Advances in biological regulation.
[22] E. Sunami,et al. Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells , 2014, Journal of Cancer Research and Clinical Oncology.
[23] K. Ryan,et al. Autophagy in tumour cell death. , 2013, Seminars in cancer biology.
[24] J. Lister,et al. A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo , 2013, The Journal of investigative dermatology.
[25] R. Tothill,et al. BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage , 2013, Clinical Cancer Research.
[26] D. Schadendorf,et al. A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. , 2013, Cancer discovery.
[27] K. Flaherty,et al. Elucidating distinct roles for NF1 in melanomagenesis. , 2013, Cancer discovery.
[28] A. Sivachenko,et al. A Landscape of Driver Mutations in Melanoma , 2012, Cell.
[29] Seok-Hyung Kim,et al. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development , 2012, Disease Models & Mechanisms.
[30] H. Spaink,et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model , 2012, The Journal of pathology.
[31] K. Leslie,et al. A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors , 2011, PloS one.
[32] D. Neuberg,et al. Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia , 2011, The Journal of experimental medicine.
[33] J. Blenis,et al. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. , 2011, Trends in biochemical sciences.
[34] David A. Orlando,et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset , 2011, Nature.
[35] L. Lam,et al. A MicroRNA Screen to Identify Modulators of Sensitivity to BCL2 Inhibitor ABT-263 (Navitoclax) , 2010, Molecular Cancer Therapeutics.
[36] L. Zon,et al. Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. , 2009, Zebrafish.
[37] M. Gottesman,et al. Influence of melanosome dynamics on melanoma drug sensitivity. , 2009, Journal of the National Cancer Institute.
[38] Wei Zhou,et al. In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models , 2009, Clinical Cancer Research.
[39] J. Dixon,et al. Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development , 2008, Oncogene.
[40] Tak W. Mak,et al. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis , 2006, Nature Reviews Cancer.
[41] L. Zon,et al. BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma , 2005, Current Biology.
[42] K. Knuth,et al. What Is a Question , 2004, physics/0403089.
[43] Sridhar Ramaswamy,et al. Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability , 2002, Cell.
[44] A. Look,et al. Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[45] F. Collins,et al. Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines , 1993, Nature Genetics.
[46] A. Letai,et al. To Prime, or Not to Prime: That Is the Question. , 2016, Cold Spring Harbor symposia on quantitative biology.
[47] Charles K Kaufman. Zebrafish Melanoma. , 2016, Advances in experimental medicine and biology.