Ganglioglioma in the cerebellopontine angle in a child. Case report and review of the literature.

The authors report a case of a posterior fossa ganglioglioma centered in the cerebellopontine angle occurring in a child. As with cortically based gangliogliomas, the primary therapy is resection. When the tumor presents in the posterior fossa, often only partial resection can be accomplished without significant neurological deficit. The role of adjuvant chemotherapy and radiation therapy remains controversial, although these are usually reserved for high-grade lesions or progressive growth. The literature regarding the natural history, surgical outcomes, and indications for adjuvant therapy is reviewed. Although it occurs rarely, ganglioglioma should be included in the differential diagnosis of a posterior fossa mass in a child or young adult.

[1]  T. Hirose,et al.  Anaplastic ganglioglioma of the cerebellopontine angle. Case report. , 2005, Neurologia medico-chirurgica.

[2]  M. Prados,et al.  Gangliogliomas: a clinicopathological study of 25 cases and review of the literature , 1993, Journal of Neuro-Oncology.

[3]  T. Masuzawa,et al.  Magnetic resonance imaging of ganglion cell tumours , 2004, Neuroradiology.

[4]  J. Mink,et al.  Progressive myoclonus in a child with a deep cerebellar mass , 2003, Neurology.

[5]  K. Ahn,et al.  Neuronal tumors of the central nervous system: radiologic findings and pathologic correlation. , 2002, Radiographics : a review publication of the Radiological Society of North America, Inc.

[6]  A. Lagares,et al.  Ganglioglioma of the brainstem: report of three cases and review of the literature. , 2001, Surgical neurology.

[7]  K. Wang,et al.  Hemifacial Seizure of Cerebellar Ganglioglioma Origin: Seizure Control by Tumor Resection , 2001, Epilepsia.

[8]  J. Chi,et al.  Cerebellopontine angle ganglioglioma: MR findings. , 2001, AJNR. American journal of neuroradiology.

[9]  Rajesh C. Dash,et al.  Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature. , 1999, Archives of pathology & laboratory medicine.

[10]  P. Stieg,et al.  Cerebellar EpilepsyCase Presentation , 1998 .

[11]  S. Weis,et al.  Ganglioglioma of the spinal cord: report of two rare cases and review of the literature. , 1997, Neurosurgery.

[12]  S. Vandenberg,et al.  Ganglioglioma: an ultrastructural and immunohistochemical study. , 1997, Cancer.

[13]  P. Ostrow,et al.  Cerebellomedullary ganglioglioma: CT and MR findings. , 1995, AJNR. American journal of neuroradiology.

[14]  J. Schramm,et al.  Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[15]  A. Riela,et al.  Hemisomatic spasms in children , 1994, Neurology.

[16]  D. Miller,et al.  Central nervous system gangliogliomas. Part 2: Clinical outcome. , 1993, Journal of neurosurgery.

[17]  D. Miller,et al.  Central nervous system gangliogliomas. Part 1: Pathology. , 1993, Journal of neurosurgery.

[18]  J. P. Mickle Ganglioglioma in Children , 1992 .

[19]  B. Volk,et al.  A clinicopathologic and immunomorphologic study of 13 cases of ganglioglioma , 1991, Cancer.

[20]  A. Friedman,et al.  Ganglioglioma: a clinical study with long-term follow-up. , 1991, Surgical neurology.

[21]  D. Miller,et al.  Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. , 1990, Human pathology.

[22]  M. Castillo,et al.  Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients. , 1990, AJNR. American journal of neuroradiology.

[23]  B. Scheithauer,et al.  Surgical Pathology of the Nervous System and its Coverings , 1976 .