Clinical‐histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium

Background  Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. The aim of this study was to relate cellular changes to symptoms and gastric emptying in patients with gastroparesis.

[1]  P. Pasricha,et al.  Cellular changes in diabetic and idiopathic gastroparesis. , 2011, Gastroenterology.

[2]  G. Farrugia,et al.  Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years , 2010, Gut.

[3]  G. Farrugia,et al.  CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. , 2010, Gastroenterology.

[4]  H. Parkman,et al.  Gastric Neuromuscular Pathology in Gastroparesis: Analysis of Full-Thickness Antral Biopsies , 2010, Digestive Diseases and Sciences.

[5]  L. W. Liu,et al.  Loss of intramuscular and submuscular interstitial cells of Cajal and associated enteric nerves is related to decreased gastric emptying in streptozotocin‐induced diabetes , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[6]  A. Vella,et al.  Diabetes mellitus and gastric emptying: questions and issues in clinical practice , 2009, Diabetes/metabolism research and reviews.

[7]  Z. Lin,et al.  Association of the status of interstitial cells of Cajal and electrogastrogram parameters, gastric emptying and symptoms in patients with gastroparesis , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[8]  Hye-Kyung Jung,et al.  Incidence , Prevalence , and Outcomes of Patients With Gastroparesis n Olmsted County , Minnesota , From 1996 to 2006 , 2022 .

[9]  G. Farrugia,et al.  Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. , 2008, Gastroenterology.

[10]  D. Cassilly,et al.  Symptoms of Gastroparesis: Use of the Gastroparesis Cardinal Symptom Index in Symptomatic Patients Referred for Gastric Emptying Scintigraphy , 2008, Digestion.

[11]  P. Pasricha,et al.  Changes in the gastric enteric nervous system and muscle: A case report on two patients with diabetic gastroparesis , 2008, BMC gastroenterology.

[12]  G. Farrugia Interstitial cells of Cajal in health and disease , 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[13]  Steven Mark Miller,et al.  Distribution of interstitial cells of Cajal and nitrergic neurons in normal and diabetic human appendix , 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[14]  M. Camilleri,et al.  Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine , 2008, The American Journal of Gastroenterology.

[15]  R. Fisher,et al.  Gastroparesis-Related Hospitalizations in the United States: Trends, Characteristics, and Outcomes, 1995–2004 , 2008, The American Journal of Gastroenterology.

[16]  Steven Mark Miller,et al.  Regulation of interstitial cells of Cajal in the mouse gastric body by neuronal nitric oxide , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[17]  P. Pasricha,et al.  Mechanisms of Disease: the pathological basis of gastroparesis—a review of experimental and clinical studies , 2007, Nature Clinical Practice Gastroenterology &Hepatology.

[18]  P. Pasricha,et al.  Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[19]  M. Camilleri Clinical practice. Diabetic gastroparesis. , 2007, The New England journal of medicine.

[20]  H. Iwasaki,et al.  A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus , 2006, Journal of Gastroenterology.

[21]  H. Sokol,et al.  Severe isolated myopathic gastroparesis: a case report with pathological findings , 2006, Gut.

[22]  C. Tomkiewicz,et al.  Expression of macrophage‐selective markers in human and rodent adipocytes , 2005, FEBS letters.

[23]  D. Revicki,et al.  Development and psychometric evaluation of the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) in patients with upper gastrointestinal disorders , 2004, Quality of Life Research.

[24]  R. Fisher,et al.  American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. , 2004, Gastroenterology.

[25]  Gianrico Farrugia,et al.  Nitric oxide in gastrointestinal health and disease. , 2004, Gastroenterology.

[26]  J. Huizinga,et al.  Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management , 2003, Gut.

[27]  R. McCallum,et al.  Absence of the interstitial cells of cajal in patients with gastroparesis and correlation with clinical findings , 2003, Journal of Gastrointestinal Surgery.

[28]  B. Geypens,et al.  Symptoms Associated With Impaired Gastric Emptying of Solids and Liquids in Functional Dyspepsia , 2003, American Journal of Gastroenterology.

[29]  M. Horowitz,et al.  Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. , 2001, Archives of internal medicine.

[30]  C. Ferris,et al.  Loss of interstitial cells of cajal and inhibitory innervation in insulin-dependent diabetes. , 2001, Gastroenterology.

[31]  M. Costa,et al.  The enteric nervous system in health and disease , 2000, Gut.

[32]  S. Ward,et al.  Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis. , 2000, Diabetes.

[33]  H. Mashimo,et al.  Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice. , 2000, Gastroenterology.

[34]  O. Suhr,et al.  Diabetic state affects the innervation of gut in an animal model of human type 1 diabetes. , 2000, Histology and histopathology.

[35]  K. Koch Diabetic Gastropathy (Gastric Neuromuscular Dysfunction in Diabetes Mellitus A Review of Symptoms, Pathophysiology, and Treatment) , 1999, Digestive Diseases and Sciences.

[36]  K. Nakamura,et al.  ["Interstitial cells of Cajal"]. , 1998, Fukuoka igaku zasshi = Hukuoka acta medica.

[37]  C. Owyang,et al.  Impaired expression of nitric oxide synthase in the gastric myenteric plexus of spontaneously diabetic rats. , 1997, Gastroenterology.

[38]  R. McCallum,et al.  Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis , 1996, Digestive Diseases and Sciences.

[39]  Y. Taché,et al.  Delayed gastric emptying induced by inhibitors of nitric oxide synthase in rats. , 1994, European journal of pharmacology.

[40]  P. Ruck,et al.  Immunoreactivity of normal and neoplastic human tissue mast cells with macrophage-associated antibodies, with special reference to the recently developed monoclonal antibody PG-M1. , 1993, Human pathology.

[41]  D. Simmons,et al.  Molecular Cloning of CD68, a Human Macrophage Marker Related to Lysosomal Glycoproteins , 1993 .

[42]  N. Talley Clinical Features of Idiopathic Gastroparesis Vary With Sex, Body Mass, Symptom Onset, Delay in Gastric Emptying, and Gastroparesis Severity , 2011 .

[43]  M. Fried,et al.  Role of Endoscopy in Motility Disorders of Upper Gastrointestinal Tract , 2023, Journal of neurogastroenterology and motility.

[44]  D. Simmons,et al.  Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. , 1993, Blood.

[45]  G. P. van Berge‐Henegouwen,et al.  Pathophysiology and treatment of functional dyspepsia. , 1993, Scandinavian journal of gastroenterology. Supplement.

[46]  L. Thuneberg Interstitial cells of Cajal , 1989 .