Alteraciones metabólicas en el alcoholismo

La ingestion sostenida de alcohol genera a nivel intermediario cambios metabolicos que favorecen la aparicion de dano hepatico grave y disfuncion del transporte axonal que decursa hacia una neuropatia axonal periferica. La malnutricion, primaria o secundaria, vinculada al alcoholismo tiene manifestaciones clinicas similares; sin embargo, la ingestion cronica de alcohol produce alteraciones del sistema de oxidorreduccion y modificaciones bioquimicas y morfologicas del transporte neuroaxonal que difieren de las que se presentan en la malnutricion e ingestion sostenida de etanol. Cuando se asocian resulta entonces dificil dilucidar un mecanismo causal comun.

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