Prevention of Hemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine.

A long-term follow-up of approximately 50,000 children who received the Hemophilus influenzae type b capsular polysaccharide vaccine in 1974 at three months to five years of age has shown good protective efficacy in those who received the vaccine at 18 months or older. No adverse effects were observed. Analysis of paired serum samples from 514 vaccinated children showed that effective immunization with this vaccine could be performed after but not before the age of 16 to 20 months. An analysis of 956 bacteremic H. influenzae infections occurring in Finland over a period of five years showed that 94 per cent of all cases were in children under 10 years of age. Of these, 40 per cent occurred in children under 18 months, and 60 per cent in children between the ages of 1 1/2 and 9 years. These 60 per cent are potentially preventable with the capsular polysaccharide vaccine.

[1]  P. Mäkelä,et al.  The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b. , 1983, The Journal of infectious diseases.

[2]  R. Schneerson,et al.  Further Studies on the Immunogenicity of Haemophilus influenzae Type b and Pneumococcal Type 6A Polysaccharide-Protein Conjugates , 1983, Infection and immunity.

[3]  P. Anderson.  Antibody Responses to Haemophilus influenzae Type b and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the Nontoxic Protein CRM197 , 1983, Infection and immunity.

[4]  J. D. Nelson.  How preventable is bacterial meningitis. , 1982, The New England journal of medicine.

[5]  J. Williams,et al.  Increase in antibiotic resistance in Haemophilus influenzae in the United Kingdom since 1977: report of study group. , 1982, British medical journal.

[6]  P. Gulig,et al.  IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN , 1982, The Lancet.

[7]  P. Offit,et al.  Ampicillin-Resistant, β-Lactamase-Negative Haemophilus influenzae Type b , 1982 .

[8]  H. Wynter,et al.  SAFETY AND IMMUNOGENICITY OF A NEW HAEMOPHILUS INFLUENZAE TYPE b VACCINE IN INFANTS UNDER ONE YEAR OF AGE , 1981, The Lancet.

[9]  H. Margolis,et al.  HAEMOPHILUS INFLUENZAE DISEASE IN ALASKAN ESKIMOS: CHARACTERISTICS OF A POPULATION WITH AN UNUSUAL INCIDENCE OF INVASIVE DISEASE , 1981, The Lancet.

[10]  D. Goldmann,et al.  Rifampin chemoprophylaxis for household contacts of patients with invasive infections due to Haemophilus influenzae type b. , 1981, Jornal de Pediatria.

[11]  F. Denis,et al.  [An epidemiological study of purulent meningitis cases admitted to hospital in Dakar, 1970-1979]. , 1981, Bulletin of the World Health Organization.

[12]  S. Sarna,et al.  Serum antibodies to capsular polysaccharide vaccine of group A Neissera meningitidis followed for three years in infants and children. , 1980, The Journal of infectious diseases.

[13]  D. Granoff,et al.  Spread of Haemophilus influenzae type b: recent epidemiologic and therapeutic considerations. , 1980, The Journal of pediatrics.

[14]  M. Leinonen,et al.  PNEUMOCOCCAL VACCINE AND OTITIS MEDIA , 1980, The Lancet.

[15]  A. Sutton,et al.  Preparation, characterization, and immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugates , 1980, The Journal of experimental medicine.

[16]  J. Gilsdorf,et al.  Comparison of rifampin and ampicillin in day care center contacts of Haemophilus influenzae type b disease. , 1980, Pediatrics.

[17]  B. Plikaytis,et al.  Haemophilus influenzae meningitis. A national study of secondary spread in household contacts. , 1979, The New England journal of medicine.

[18]  J. Gilsdorf,et al.  Haemophilus influenzae type B disease in a day care center: eradication of carrier state by rifampin. , 1979, Pediatrics.

[19]  A. Dajani,et al.  Systemic Haemophilus influenzae disease: an overview. , 1979, The Journal of pediatrics.

[20]  J. C. Parke,et al.  ASSOCIATION BETWEEN IMMUNOGLOBULIN ALLOTYPES AND IMMUNE RESPONSES TO HÆMOPHILUS INFLUENZÆ AND MENINGOCOCCUS POLYSACCHARIDES , 1979, The Lancet.

[21]  A. T. Davis,et al.  Effect of TMP-SMX on nasopharyngeal carriage of ampicillin-sensitive and ampicillin-resistant hemophilus influenzae type B. , 1978, The Journal of pediatrics.

[22]  P. Mäkelä,et al.  Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland. , 1977, Pediatrics.

[23]  E. Ruoslahti,et al.  Polysaccharide vaccines of group A Neisseria meningtitidis and Haemophilus influenzae type b: a field trial in Finland. , 1977, The Journal of infectious diseases.

[24]  R. Molteni.  Epiglottitis: incidence of extraepiglottic infection: report of 72 cases and review of the literature. , 1976, Pediatrics.

[25]  J. Nelson,et al.  Residual Effects of Septic Arthritis in Infancy and Childhood , 1976 .

[26]  F. Bruhn,et al.  Severe Haemophilus influenzae infections. Spectrum of disease. , 1975 .

[27]  J. C. Parke,et al.  Quantitative Measurement of “Natural” and Immunization-induced Haemophilus influenzas type b Capsular Polysaccharide Antibodies , 1973, Pediatric Research.

[28]  S. Sell,et al.  Long-term sequelae of Hemophilus influenzae meningitis. , 1972, Pediatrics.

[29]  P. Anderson,et al.  Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b. , 1972, The Journal of clinical investigation.

[30]  J. C. Parke,et al.  Immunity to disease caused by Hemophilus influenzae type b. II. Specificity and some biologic characteristics of "natural," infection-acquired, and immunization-induced antibodies to the capsular polysaccharide of Hemophilus influenzae type b. , 1971, Journal of immunology.

[31]  S. Sell.  The clinical importance of Hemophilus influenzae infections in children. , 1970, Pediatric clinics of North America.

[32]  R. E. Merrill,et al.  Meningitis due to Hemophilus influenzae: long-term sequelae. , 1969, The Journal of pediatrics.

[33]  Joyce M. Wright,et al.  Influenzal Meningitis The Relation of Age Incidence to the Bactericidal Power of Blood Against the Causal Organism , 1933 .