Current applications and new trends in mid-infrared sensor technology and integrated scanning probe sensors

Chemical sensor technology is one of the fastest growing research areas and can be identified as a key technological area in modern analytical chemistry. The increasing interest in sensing systems is driven to a significant extent by the multifaceted range of in-situ and on-line applications, demanded in the field of industrial process analysis and control, environmental monitoring, biological/biochemical analysis and high-throughput screening in the medical/pharmaceutical field. Advanced mid-infrared sensor systems and integrated scanning probe sensors, contribute to the most recent trends in sensor technology: (i) arrayed information; (ii) microfabrication technologies for sensor miniaturization; (iii) improved selectivity; and (iv) novel application areas. Based on an integral approach for the development of novel sensor technologies the first application of quantum cascade lasers in an IR sensor format has been demonstrated, facilitated by microfabrication technologies. With the introduction of molecularly imprinted polymers as biomimetic sensing layer for specific analyte recognition in combination with evanescent field infrared spectroscopy, a novel concept utilizing orthogonal information from a selective membrane and an inherently selective transducer has been introduced.

[1]  Karsten Haupt,et al.  Molecularly Imprinted Polymers and Infrared Evanescent Wave Spectroscopy. A Chemical Sensors Approach , 1999 .

[2]  J. Janata Peer Reviewed: Centennial Retrospective on Chemical Sensors , 2001 .

[3]  Boris Mizaikoff,et al.  Surface enhanced infrared absorption spectroscopy (SEIRA) using external reflection on low-cost substrates , 1998 .

[4]  Olof Ramström,et al.  The Emerging Technique of Molecular Imprinting and Its Future Impact on Biotechnology , 1996, Bio/Technology.

[5]  Matthew J. Hall,et al.  Fast-spec: An infrared spectroscopic diagnostic to measure time-resolved exhaust hydrocarbon emissions from S.I. engines , 1998 .

[6]  Abraham Katzir,et al.  Towards a remote IR fiber-optic sensor system for the determination of chlorinated hydrocarbons in water , 1997 .

[7]  A. Bard,et al.  Scanning Electrochemical and Tunneling Ultramicroelectrode Microscope for High-Resolution Examination of Electrode Surfaces in Solution , 1986 .

[8]  Boris Mizaikoff,et al.  Application of Sapphire Fibers to an IR Fiber-Optic Sensor for the Investigation of Polymers at Elevated Temperature , 1998 .

[9]  B. Mizaikoff,et al.  Surface-Enhanced Vibrational Spectroscopy: A New Tool in Chemical IR Sensing? , 1997 .

[10]  J. Chalmers,et al.  Handbook of vibrational spectroscopy , 2002 .

[11]  A. Molinelli,et al.  Molecular imprinting and solid phase extraction of flavonoid compounds , 2001, Bioseparation.

[12]  Erich Gornik,et al.  GaAs/AlGaAs superlattice quantum cascade lasers at λ≈13 μm , 1999 .

[13]  Robert Weiss,et al.  Molecularly Imprinted Polymers for Nitrophenols - An Advanced Separation Material for Environmental Analysis , 2001 .

[14]  Rudolf Krska,et al.  Infrared fiber-optical chemical sensors with reactive surface coatings , 1995 .

[15]  B. Mizaikoff,et al.  Fabrication of a ring nanoelectrode in an AFM tip: novel approach towards simultaneous electrochemical and topographical imaging , 2002 .

[16]  Faist,et al.  Mid-infrared quantum cascade lasers for flow injection analysis , 2000, Analytical chemistry.

[17]  J. Faist,et al.  Quantum cascade laser: a unipolar intersubband semiconductor laser , 1994, Proceedings of IEEE 14th International Semiconductor Laser Conference.

[18]  Abraham Katzir,et al.  Chemically Tapered Silver Halide Fibers: An Approach for Increasing the Sensitivity of Mid-Infrared Evanescent Wave Sensors , 2000 .

[19]  B. Mizaikoff,et al.  Integrating an ultramicroelectrode in an AFM cantilever: combined technology for enhanced information. , 2001, Analytical chemistry.

[20]  G. Wulff,et al.  Molecular Imprinting in Cross-Linked Materials with the Aid of Molecular Templates - A Way towards Artificial Antibodies , 1995 .

[21]  Abraham Katzir,et al.  Detection of Hydrocarbons in Water by MIR Evanescent-Wave Spectroscopy with Flattened Silver Halide Fibers , 2001 .

[22]  R. Engstrom,et al.  Measurements within the diffusion layer using a microelectrode probe , 1986 .

[23]  Boris Mizaikoff Recent trends in mid-infrared sensing , 2001, SPIE BiOS.

[24]  Boris Mizaikoff,et al.  Mid-infrared sensors for marine monitoring , 2001, SPIE Optics East.

[25]  Abraham Katzir,et al.  Optimizing the modulation for evanescent-wave analysis with laser diodes (EWALD) for monitoring chlorinated hydrocarbons in water , 1997 .

[26]  S. E. Hobbs,et al.  Optical waveguide sensors in analytical chemistry: today’s instrumentation, applications and trends for future development , 1998 .