A hippocampal lesion detected by high-field 3 tesla magnetic resonance imaging in a patient with temporal lobe epilepsy.

Nearly 80% of patients with temporal lobe epilepsy have some types of lesion identified by conventional 1.5 tesla (T) magnetic resonance imaging (MRI). We performed high-field 3 T MRI in a 5-year-old patient with recurrent complex partial seizures who was diagnosed as having right temporal lobe epilepsy based on the results of single photon emission computed tomography and ictal video-electroencephalogram monitoring, because 1.5 T MRI failed to detect any abnormalities in the suspected region. High-field 3 T MRI revealed a small high-intensity lesion on fast spin-echo short inversion time inversion-recovery images of the hippocampus, possibly responsible for the seizures. This is the first report detecting a hippocampal lesion by 3 T MRI, which could not be found by conventional 1.5 T MRI.

[1]  F. Cendes,et al.  Early development destructive brain lesions and their relationship to epilepsy and hippocampal damage , 2003, Brain and Development.

[2]  Anne Williamson,et al.  A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories , 2003, Epilepsia.

[3]  Beate Diehl,et al.  Neocortical Temporal FDG‐PET Hypometabolism Correlates with Temporal Lobe Atrophy in Hippocampal Sclerosis Associated with Microscopic Cortical Dysplasia , 2003, Epilepsia.

[4]  L. Carmant,et al.  The pathological basis of temporal lobe epilepsy in childhood , 2003, Neurology.

[5]  L. Martinian,et al.  Cytoarchitectural Abnormalities in Hippocampal Sclerosis , 2002, Journal of neuropathology and experimental neurology.

[6]  O. Wiestler,et al.  Ammon's Horn Sclerosis: A Maldevelopmental Disorder Associated with Temporal Lobe Epilepsy , 2002, Brain pathology.

[7]  Regula S Briellmann,et al.  Hippocampal pathology in refractory temporal lobe epilepsy , 2002, Neurology.

[8]  Ari Syngeniotis,et al.  Comparison of Hippocampal Volumetry at 1.5 Tesla and at 3 Tesla , 2001, Epilepsia.

[9]  T. Babb,et al.  Temporal lobe epilepsy due to hippocampal sclerosis in pediatric candidates for epilepsy surgery , 2001, Neurology.

[10]  High-field, high-resolution MR imaging of the human indusium griseum. , 1999, AJNR. American journal of neuroradiology.

[11]  D. Hadley,et al.  Interictal Temporal Hypoperfusion Is Related to Early‐Onset Temporal Lobe Epilepsy , 1996, Epilepsia.

[12]  R. Kuzniecky,et al.  Hippocampal sclerosis without detectable hippocampal atrophy , 1994, Neurology.

[13]  D. Spencer,et al.  Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination , 1993, Annals of neurology.

[14]  A Connelly,et al.  Optimizing the diagnosis of hippocampal sclerosis using MR imaging. , 1993, AJNR. American journal of neuroradiology.

[15]  Jacqueline A. French,et al.  Characteristics of medial temporal lobe epilepsy , 1993 .

[16]  J. Doppman,et al.  Short-Ti inversion-recovery pulse sequence: analysis and initial experience in cancer imaging. , 1988, Radiology.