Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression.
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K. Sabapathy | S. Gan | C. Lim | A. Chua | T. Phan | Zhenying Fu | Colin Song | Yixin Ting
[1] G. Mutlu,et al. Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. , 2011, American journal of respiratory cell and molecular biology.
[2] K. Sabapathy,et al. The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring. , 2011, The Journal of investigative dermatology.
[3] Wei He,et al. Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction , 2010, Proceedings of the National Academy of Sciences.
[4] Scott M. Williams,et al. Epigenetically altered wound healing in keloid fibroblasts. , 2010, The Journal of investigative dermatology.
[5] P. Bovolenta,et al. The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events. , 2010, The Tohoku journal of experimental medicine.
[6] N. Nara,et al. Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. , 2009, Anticancer research.
[7] R. Pignolo,et al. The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling. , 2009, Cytokine & growth factor reviews.
[8] P. Neth,et al. Wnt signalling in mouse mesenchymal stem cells: impact on proliferation, invasion and MMP expression , 2009, Journal of cellular and molecular medicine.
[9] Y. Akasaka,et al. Promoted activation of matrix metalloproteinase (MMP)‐2 in keloid fibroblasts and increased expression of MMP‐2 in collagen bundle regions: implications for mechanisms of keloid progression , 2009, Histopathology.
[10] I. Nishimoto,et al. Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways. , 2008, Cellular signalling.
[11] W. Seeger,et al. Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis , 2008, PloS one.
[12] Scott M. Williams,et al. Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. , 2008, The Journal of investigative dermatology.
[13] M. Longaker,et al. Current progress in keloid research and treatment. , 2008, Journal of the American College of Surgeons.
[14] Shaoqiong Chen,et al. The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts , 2007, Journal of Cell Communication and Signaling.
[15] C. Zhang,et al. Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells , 2007, Acta Pharmacologica Sinica.
[16] M. Longaker,et al. Increased CCN2 Transcription in Keloid Fibroblasts Requires Cooperativity Between AP-1 and SMAD Binding Sites , 2007 .
[17] Rocky S Tuan,et al. Canonical and non‐canonical wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells , 2007, Journal of cellular physiology.
[18] Mala Sinha,et al. Secreted Frizzled-Related Protein 1 Loss Contributes to Tumor Phenotype of Clear Cell Renal Cell Carcinoma , 2007, Clinical Cancer Research.
[19] Sung-Eun Kim,et al. EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation. , 2007, Cellular signalling.
[20] D. O'Gorman,et al. β-Catenin Signaling in Fibroproliferative Disease , 2007 .
[21] Beibei Wu,et al. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. , 2007, Immunity.
[22] M. Waterman,et al. Diversity of LEF/TCF action in development and disease , 2006, Oncogene.
[23] Xinmin Cao,et al. Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration , 2006, Oncogene.
[24] P. Neth,et al. Wnt Signaling Regulates the Invasion Capacity of Human Mesenchymal Stem Cells , 2006, Stem cells.
[25] U. Mrowietz,et al. Quality of life of patients with keloid and hypertrophic scarring , 2006, Archives of Dermatological Research.
[26] A. Ooshima,et al. Keloid‐derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration , 2005, The British journal of dermatology.
[27] Chul-hak Yang,et al. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. , 2005, Biochemical and biophysical research communications.
[28] B. Alman,et al. Prolonged β-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds , 2005, Laboratory Investigation.
[29] S. Jeon,et al. Both ERK and Wnt/β-catenin pathways are involved in Wnt3a-induced proliferation , 2005, Journal of Cell Science.
[30] D. Kerr,et al. Signal transduction blockade and cancer: combination therapy or multi-targeted inhibitors? , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[31] M. Longaker,et al. Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. , 2004, The Journal of trauma.
[32] T. Brabletz,et al. β‐Catenin activates a coordinated expression of the proinvasive factors laminin‐5 γ2 chain and MT1‐MMP in colorectal carcinomas , 2004 .
[33] B. Alman,et al. Elevated levels of β-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro , 2003, BMC Musculoskeletal Disorders.
[34] Yoshiaki Kawano,et al. Secreted antagonists of the Wnt signalling pathway , 2003, Journal of Cell Science.
[35] H. Huynh,et al. Suppression of insulin‐like growth factor signalling pathway and collagen expression in keloid‐derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids , 2003, The British journal of dermatology.
[36] Yusuke Nakamura,et al. Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers , 2002, Oncogene.
[37] F. Wood,et al. [International clinical recommendations on scar management]. , 2002, Zentralblatt fur Chirurgie.
[38] K. Shimotohno,et al. Wnt/β‐catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts , 2002, International journal of cancer.
[39] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[40] M Kon,et al. On the nature of hypertrophic scars and keloids: a review. , 1999, Plastic and reconstructive surgery.
[41] Doris Wedlich,et al. The Wnt/Wg Signal Transducer β-Catenin Controls Fibronectin Expression , 1999, Molecular and Cellular Biology.
[42] M. Yamauchi,et al. Altered posttranslational modifications of collagen in keloid. , 1998, Biochemical and biophysical research communications.
[43] R. Tuan,et al. Major suppression of pro-alpha1(I) type I collagen gene expression in the dermis after keloid excision and immediate intrawound injection of triamcinolone acetonide. , 1997, Journal of the American Academy of Dermatology.
[44] Gary R. Grotendorst,et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. , 1996, The Journal of investigative dermatology.
[45] A. Banes,et al. Increased proliferation in keloid fibroblasts wounded in vitro. , 1996, The Journal of surgical research.
[46] R. Diegelmann,et al. Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing , 1989, Molecular and cellular biology.
[47] J. Uitto,et al. Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[48] M. Hendrix,et al. Fibronectin (FN) in hypertrophic scars and keloids , 1983, Cell and Tissue Research.
[49] Madoka Sato. Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. , 2006, Acta dermato-venereologica.
[50] T. Tuan,et al. The molecular basis of keloid and hypertrophic scar formation. , 1998, Molecular medicine today.