The Human Genome Diversity Project: past, present and future

The Human Genome Project, in accomplishing its goal of sequencing one human genome, heralded a new era of research, a component of which is the systematic study of human genetic variation. Despite delays, the Human Genome Diversity Project has started to make progress in understanding the patterns of this variation and its causes, and also promises to provide important information for biomedical studies.

[1]  R. Sanger,et al.  Blood Groups in Man , 1959 .

[2]  Luigi Luca Cavalli-Sforza,et al.  The genetics of human populations. , 1972, Scientific American.

[3]  L. Cavalli-Sforza,et al.  Some current problems of human population genetics , 1973 .

[4]  L L Cavalli-Sforza,et al.  Analytic review: some current problems of human population genetics. , 1973, American journal of human genetics.

[5]  H. Harris The principles of human biochemical genetics , 1975 .

[6]  P. Menozzi,et al.  Synthetic maps of human gene frequencies in Europeans. , 1978, Science.

[7]  K. Kidd,et al.  DNA markers and genetic variation in the human species. , 1986, Cold Spring Harbor symposia on quantitative biology.

[8]  "How Can One Study Individual Variation for Three Billion Nucleotides of Human Genome?" [Draft] , 1989 .

[9]  L. Cavalli-Sforza Opinion: how can one study individual variation for 3 billion nucleotides of the human genome? , 1990, American journal of human genetics.

[10]  H. Cann,et al.  Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. , 1990, Genomics.

[11]  C R Cantor,et al.  Call for a worldwide survey of human genetic diversity: a vanishing opportunity for the Human Genome Project. , 1991, Genomics.

[12]  L. Cavalli-Sforza,et al.  High resolution of human evolutionary trees with polymorphic microsatellites , 1994, Nature.

[13]  D. F. Roberts,et al.  The History and Geography of Human Genes , 1996 .

[14]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[15]  G Barbujani,et al.  An apportionment of human DNA diversity. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Division on Earth Evaluating Human Genetic Diversity , 1998 .

[17]  L. Cavalli-Sforza The DNA revolution in population genetics. , 1998, Trends in genetics : TIG.

[18]  Bruno J. Strasser,et al.  "Sickle Cell Anemia, a Molecular Disease" , 1999, Science.

[19]  P. Donnelly,et al.  Inference of population structure using multilocus genotype data. , 2000, Genetics.

[20]  H. Greely Human genome diversity: What about the other human genome project? , 2001, Nature Reviews Genetics.

[21]  Pardis C Sabeti,et al.  Linkage disequilibrium in the human genome , 2001, Nature.

[22]  L L Cavalli-Sforza,et al.  The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations , 2001, Annals of human genetics.

[23]  M. Feldman,et al.  Genetic Structure of Human Populations , 2002, Science.

[24]  Jonathan Scott Friedlaender,et al.  A Human Genome Diversity Cell Line Panel , 2002, Science.

[25]  M. Feldman,et al.  The application of molecular genetic approaches to the study of human evolution , 2003, Nature Genetics.

[26]  Read all about it: The Lancet's Paper of the Year, 2003 , 2003, The Lancet.

[27]  Toshihiro Tanaka The International HapMap Project , 2003, Nature.

[28]  K. Christensen,et al.  Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathway genes MTHFR, MTHFD, MTRR, RFC1, and GCP2. , 2003, Birth defects research. Part A, Clinical and molecular teratology.

[29]  M. Feldman,et al.  Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers. , 2003, American journal of human genetics.

[30]  M. Feldman,et al.  Robustness of the inference of human population structure: A comparison of X-chromosomal and autosomal microsatellites , 2004, Human Genomics.

[31]  J. Wall,et al.  Haplotype blocks and linkage disequilibrium in the human genome , 2003, Nature Reviews Genetics.

[32]  P. Donnelly,et al.  The Fine-Scale Structure of Recombination Rate Variation in the Human Genome , 2004, Science.

[33]  Pardis C Sabeti,et al.  Genetic signatures of strong recent positive selection at the lactase gene. , 2004, American journal of human genetics.

[34]  M. W. Foster,et al.  Integrating ethics and science in the International HapMap Project , 2004, Nature Reviews Genetics.

[35]  S. Pääbo,et al.  Evidence for gradients of human genetic diversity within and among continents. , 2004, Genome research.

[36]  C. Roseman Detecting interregionally diversifying natural selection on modern human cranial form by using matched molecular and morphometric data. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Christopher A. Edmonds,et al.  Mutations arising in the wave front of an expanding population. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Feldman,et al.  Demographic estimates from Y chromosome microsatellite polymorphisms: Analysis of a worldwide sample , 2004, Human Genomics.

[39]  H. Bellen,et al.  Emerging technologies for gene manipulation in Drosophila melanogaster , 2005, Nature Reviews Genetics.