Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness

[1]  S. Johnston,et al.  A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13) , 2017, EBioMedicine.

[2]  S. Johnston,et al.  Raised interferon‐β, type 3 interferon and interferon‐stimulated genes – evidence of innate immune activation in neutrophilic asthma , 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[3]  M. Kowalski,et al.  IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma , 2017, European Respiratory Journal.

[4]  M. Jarzębska,et al.  Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis , 2017, Clinical and experimental immunology.

[5]  C. Andrewes,et al.  Virus interference. I. The interferon , 2017 .

[6]  P. Rigby,et al.  Impaired airway epithelial cell responses from children with asthma to rhinoviral infection , 2016, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  P. Sly,et al.  Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70 , 2016, Journal of Innate Immunity.

[8]  I. Pavord,et al.  Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. , 2016, The Lancet. Respiratory medicine.

[9]  P. Howarth,et al.  Toll-like Receptor 7 Is Reduced in Severe Asthma and Linked to an Altered MicroRNA Profile. , 2016, American journal of respiratory and critical care medicine.

[10]  J. Johnston,et al.  Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma , 2016, European Respiratory Journal.

[11]  P. Sly,et al.  Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity. , 2016, The Journal of allergy and clinical immunology.

[12]  Irah L. King,et al.  Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells , 2015, Nature Immunology.

[13]  M. Rattray,et al.  Phenotyping immune responses In asthma and respiratory infections , 2016 .

[14]  P. Gergen,et al.  Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations. , 2015, The Journal of allergy and clinical immunology.

[15]  Charles M. Rice,et al.  Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response , 2015, Nature.

[16]  A. Spanevello,et al.  Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells , 2015, Allergy.

[17]  S. Johnston,et al.  Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons , 2015, The Journal of allergy and clinical immunology.

[18]  S. Johnston,et al.  Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia , 2015, Thorax.

[19]  C. Bachert,et al.  Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. , 2015, The New England journal of medicine.

[20]  N. Papadopoulos,et al.  IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. , 2014, American journal of respiratory and critical care medicine.

[21]  M. Castro,et al.  Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. , 2014, The Journal of allergy and clinical immunology.

[22]  W. Busse,et al.  Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. , 2014, The Lancet. Respiratory medicine.

[23]  Andrew McKenzie,et al.  Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation , 2014, Science Translational Medicine.

[24]  M. Sarwal,et al.  A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation , 2014, Science Translational Medicine.

[25]  J. Bell,et al.  Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459 , 2014, Allergy.

[26]  A. Heinzmann,et al.  Fine‐mapping of IgE‐associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data , 2014, Allergy.

[27]  N. Thomson,et al.  The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. , 2014, American journal of respiratory and critical care medicine.

[28]  P. Sly,et al.  Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy , 2014, Thorax.

[29]  A. Zwinderman,et al.  dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls , 2014, Respiratory Research.

[30]  J. Fahy.  Type 2 inflammation in asthma — present in most, absent in many , 2014, Nature Reviews Immunology.

[31]  S. Johnston,et al.  Rhinovirus-induced interferon production is not deficient in well controlled asthma , 2013, Thorax.

[32]  Ruksha Bhadresha.  Dupilumab in persistent asthma with elevated eosinophil levels , 2013, Thorax.

[33]  H. Tomizawa,et al.  TLR7 Stimulation of APCs Results in Inhibition of IL-5 through Type I IFN and Notch Signaling Pathways in Human Peripheral Blood Mononuclear Cells , 2013, The Journal of Immunology.

[34]  S. Johnston,et al.  The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity , 2013, Nature Medicine.

[35]  S. Johnston,et al.  Impaired innate interferon induction in severe therapy resistant atopic asthmatic children , 2012, Mucosal Immunology.

[36]  M. Contoli,et al.  Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma. , 2012, The Journal of allergy and clinical immunology.

[37]  S. Johnston,et al.  Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus , 2012, EMBO molecular medicine.

[38]  P. Howarth,et al.  Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response , 2012, PloS one.

[39]  Ian D Pavord,et al.  Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial , 2012, The Lancet.

[40]  R. Gangnon,et al.  Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children. , 2012, The Journal of allergy and clinical immunology.

[41]  Julie G. Burel,et al.  Innate IFNs and Plasmacytoid Dendritic Cells Constrain Th2 Cytokine Responses to Rhinovirus: A Regulatory Mechanism with Relevance to Asthma , 2012, The Journal of Immunology.

[42]  S. Johnston,et al.  The microbiology of asthma , 2012, Nature Reviews Microbiology.

[43]  S. Johnston,et al.  Rhinovirus 16-induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients. , 2012, The Journal of allergy and clinical immunology.

[44]  P. Sly,et al.  Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment , 2012, Nature Medicine.

[45]  L. Boulet,et al.  Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. , 2011, American journal of respiratory and critical care medicine.

[46]  Nicola A Hanania,et al.  Lebrikizumab treatment in adults with asthma. , 2011, The New England journal of medicine.

[47]  H. Ida,et al.  Peripheral Blood Mononuclear Cells from Patients with Bronchial Asthma Show Impaired Innate Immune Responses to Rhinovirus in vitro , 2011, International Archives of Allergy and Immunology.

[48]  M. Neurath,et al.  IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease , 2011, EMBO molecular medicine.

[49]  P. Howarth,et al.  Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus. , 2011, The Journal of allergy and clinical immunology.

[50]  David J. Miller,et al.  MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness , 2011, PLoS pathogens.

[51]  P. Gergen,et al.  Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. , 2011, The New England journal of medicine.

[52]  Barmak Modrek,et al.  Gene Expression Patterns of Th2 Inflammation and Intercellular Communication in Asthmatic Airways , 2011, The Journal of Immunology.

[53]  S. Johnston,et al.  Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium , 2010, PLoS pathogens.

[54]  Florence Demenais,et al.  A large-scale, consortium-based genomewide association study of asthma. , 2010, The New England journal of medicine.

[55]  Wai-ming Lee,et al.  Association between human rhinovirus C and severity of acute asthma in children , 2010, European Respiratory Journal.

[56]  A. Chang,et al.  Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital , 2010, Journal of medical virology.

[57]  J. Farrar,et al.  Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3 , 2010, The Journal of Immunology.

[58]  P. Howarth,et al.  Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-β in bronchial epithelial cells from donors with asthma , 2010, Thorax.

[59]  M. Gill,et al.  Counterregulation between the FcεRI Pathway and Antiviral Responses in Human Plasmacytoid Dendritic Cells , 2010, The Journal of Immunology.

[60]  S. Keleş,et al.  Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma , 2010, Mucosal Immunology.

[61]  Parameswaran Nair,et al.  Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. , 2009, The New England journal of medicine.

[62]  David J. Miller,et al.  Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses1 , 2009, The Journal of Immunology.

[63]  Anthony Bosco,et al.  Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children1 , 2009, The Journal of Immunology.

[64]  H. Boushey,et al.  In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. , 2009, The Journal of allergy and clinical immunology.

[65]  M. Kubo,et al.  Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype. , 2009, American journal of respiratory and critical care medicine.

[66]  P. Gibson,et al.  Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains , 2009, Respirology.

[67]  P. Bardin,et al.  Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses. , 2009, American journal of respiratory cell and molecular biology.

[68]  K. Heeg,et al.  Identification of a nuclear localization signal in suppressor of cytokine signaling 1 , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[69]  David Proud,et al.  Gene expression profiles during in vivo human rhinovirus infection: insights into the host response. , 2008, American journal of respiratory and critical care medicine.

[70]  S. Johnston,et al.  Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production , 2008, Proceedings of the National Academy of Sciences.

[71]  M. Nyegaard,et al.  Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders , 2008, Thorax.

[72]  M. Chignard,et al.  Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway1 , 2008, The Journal of Immunology.

[73]  R. A. Killington,et al.  Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation , 2008, Nature Medicine.

[74]  S. Wenzel,et al.  Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies , 2007, The Lancet.

[75]  Yee Hwa Yang,et al.  Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids , 2007, Proceedings of the National Academy of Sciences.

[76]  Yusuke Nakamura,et al.  Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. , 2007, American journal of respiratory cell and molecular biology.

[77]  W. Teague,et al.  Prevalence of viral respiratory tract infections in children with asthma , 2006, Journal of Allergy and Clinical Immunology.

[78]  Charles M. Rice,et al.  Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics , 2006 .

[79]  Y. Becker.  Respiratory syncytial virus(RSV)-induced allergy may be controlled by IL-4 and CX3C fractalkine antagonists and CpG ODN as adjuvant: hypothesis and implications for treatment , 2006, Virus Genes.

[80]  Stephen T Holgate,et al.  Role of deficient type III interferon-λ production in asthma exacerbations , 2006, Nature Medicine.

[81]  A. Bufe,et al.  Impaired virus‐induced interferon‐α2 release in adult asthmatic patients , 2006 .

[82]  C. Rice,et al.  Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. , 2006, Gastroenterology.

[83]  S. Johnston,et al.  Role of deficient type III interferon-lambda production in asthma exacerbations. , 2006, Nature medicine.

[84]  A. Bufe,et al.  Impaired virus-induced interferon-alpha2 release in adult asthmatic patients. , 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[85]  A. Woodcock,et al.  Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children , 2005, Thorax.

[86]  S. Johnston,et al.  Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus , 2005, The Journal of experimental medicine.

[87]  S. Johnston,et al.  The September epidemic of asthma exacerbations in children: A search for etiology , 2004, Journal of Allergy and Clinical Immunology.

[88]  R. Wood,et al.  FREQUENCY, SEVERITY, AND DURATION OF RHINOVIRUS INFECTIONS IN ASTHMATIC AND NONASTHMATIC INDIVIDUALS: A LONGITUDINAL COHORT STUDY , 2003, Pediatrics.

[89]  A. Lewis-Antes,et al.  IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. , 2003, Nature immunology.

[90]  I. Pavord,et al.  Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial , 2002, The Lancet.

[91]  A. Woodcock,et al.  Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study , 2002, BMJ : British Medical Journal.

[92]  Stephen T Holgate,et al.  Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study , 2002, The Lancet.

[93]  M. Ernst,et al.  Atopic Phenotype in Children Is Associated with Decreased Virus-Induced Interferon-α Release , 2002, International Archives of Allergy and Immunology.

[94]  M. Ernst,et al.  Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release. , 2002, International archives of allergy and immunology.

[95]  B. Williams,et al.  Functional classification of interferon‐stimulated genes identified using microarrays , 2001, Journal of leukocyte biology.

[96]  B. Kjellman,et al.  Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. , 2000, American journal of respiratory and critical care medicine.

[97]  M. Hagen,et al.  Atypical Pulmonary Eosinophilia Is Mediated by a Specific Amino Acid Sequence of the Attachment (G) Protein of Respiratory Syncytial Virus , 1998, The Journal of experimental medicine.

[98]  B. García-Barreno,et al.  Eliminating a Region of Respiratory Syncytial Virus Attachment Protein Allows Induction of Protective Immunity without Vaccine-enhanced Lung Eosinophilia , 1998, The Journal of experimental medicine.

[99]  E. Gelfand,et al.  Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. , 1997, The Journal of clinical investigation.

[100]  W. Calhoun,et al.  Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. , 1997, American journal of respiratory and critical care medicine.

[101]  M J Campbell,et al.  The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. , 1996, American journal of respiratory and critical care medicine.

[102]  Stephen T Holgate,et al.  Community study of role of viral infections in exacerbations of asthma in 9-11 year old children , 1995, BMJ.