A nanofluidic channel with embedded transverse nanoelectrodes

In this paper, we demonstrate fabrication and characterization of a nanofluidic channel with embedded transverse nanoelectrodes using a combination of conventional photolithography and focused ion beam technologies. Glass-capped silicon dioxide nanochannels having 20 nm depth, 50 nm width, and 2 microm length with embedded platinum nanoelectrodes were fabricated. Channel patency was verified through measurements of the resistivity in phosphate buffered saline and electrostatic action on charged fluorescent nanospheres. Platinum nanoelectrode functionality was also tested using transverse resistance measurements in nanochannels filled with air, deionized water, and saline solution.

[1]  Thomas George,et al.  A Nanochannel Fabrication Technique without Nanolithography , 2003 .

[2]  Youngkyun Jung Velocity inversion in nanochannel flow. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[3]  Robert H. Austin,et al.  Fabrication of 10 nm enclosed nanofluidic channels , 2002 .

[4]  A NANOCHANNEL FABRICATION TECHNOLOGY WITHOUT NANOLITHOGRAPHY , 2003 .

[5]  Erwin Frey,et al.  Statics and dynamics of single DNA molecules confined in nanochannels. , 2005, Physical review letters.

[6]  Andre Marziali,et al.  Noise analysis and reduction in solid-state nanopores , 2007 .

[7]  Christian H. Reccius,et al.  Conformation, length, and speed measurements of electrodynamically stretched DNA in nanochannels. , 2008, Biophysical journal.

[8]  X. Gong,et al.  Water permeation and wavelike density distributions inside narrow nanochannels , 2008 .

[9]  G. López,et al.  Electrokinetic transport and separations in fluidic nanochannels , 2007, Electrophoresis.

[10]  K. Schulten,et al.  The electromechanics of DNA in a synthetic nanopore. , 2006, Biophysical journal.

[11]  C. Dekker,et al.  Pressure-driven transport of confined DNA polymers in fluidic channels , 2006, Proceedings of the National Academy of Sciences.

[12]  Jongyoon Han,et al.  Fabrication and characterization of 20 nm planar nanofluidic channels by glass-glass and glass-silicon bonding. , 2005, Lab on a chip.

[13]  Zhonghe Jin,et al.  Design and fabrication of a nanofluidic channel by selective thermal oxidation and etching back of silicon dioxide made on a silicon substrate , 2007 .

[14]  G. Kovacs Micromachined Transducers Sourcebook , 1998 .

[15]  M. Ventra,et al.  Colloquium: Physical approaches to DNA sequencing and detection , 2007, 0708.2724.

[16]  Babak Ziaie,et al.  Hermeticity Testing Of Glass-silicon Packages With On Chip Feed Throughs , 1995, Proceedings of the International Solid-State Sensors and Actuators Conference - TRANSDUCERS '95.

[17]  S. Pennathur,et al.  Electrokinetic transport in nanochannels. 2. Experiments. , 2005, Analytical chemistry.

[18]  Miko Elwenspoek,et al.  2D-Confined Nanochannels Fabricated by Conventional Micromachining , 2002 .

[19]  Miko Elwenspoek,et al.  Institute of Physics Publishing Journal of Micromechanics and Microengineering Wet Anisotropic Etching for Fluidic 1d Nanochannels , 2022 .

[20]  R. Ahuja,et al.  Functionalized nanopore-embedded electrodes for rapid DNA sequencing , 2007, 0708.4011.

[21]  N. Aluru,et al.  Charge inversion and flow reversal in a nanochannel electro-osmotic flow. , 2004, Physical review letters.

[22]  S. Gawad,et al.  Micromachined impedance spectroscopy flow cytometer for cell analysis and particle sizing. , 2001, Lab on a chip.

[23]  H. Jansen,et al.  Elastocapillary filling of deformable nanochannels , 2007 .

[24]  K. Schulten,et al.  Microscopic Kinetics of DNA Translocation through synthetic nanopores. , 2004, Biophysical journal.

[25]  K. Healy Nanopore-based single-molecule DNA analysis. , 2007, Nanomedicine.

[26]  Jane E. Curtin,et al.  Nanochannel fabrication for chemical sensors , 1997 .

[27]  A. Majumdar,et al.  Electrostatic control of ions and molecules in nanofluidic transistors. , 2005, Nano letters.