Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors.
暂无分享,去创建一个
[1] R. Townley,et al. Glucocorticoids inhibit proliferation and interleukin-4 and interleukin-5 secretion by aeroallergen-specific T-helper type 2 cell lines. , 1998, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[2] M. Billah,et al. The inhibitory effects of topically active glucocorticoids on IL-4, IL-5, and interferon-gamma production by cultured primary CD4+ T cells. , 1997, The Journal of allergy and clinical immunology.
[3] R. Townley,et al. Glucocorticosteroids inhibit leukotriene production. , 1997, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[4] S. Szefler,et al. Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma. , 1996, The Journal of allergy and clinical immunology.
[5] S Jacobitz,et al. Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding. , 1996, Molecular pharmacology.
[6] W. Henderson,et al. Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. , 1996, The Journal of investigative dermatology.
[7] M. Giembycz,et al. Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma? , 1996, Thorax.
[8] S. Wenzel,et al. Interleukin-10 regulation in normal subjects and patients with asthma. , 1996, Journal of Allergy and Clinical Immunology.
[9] R. Townley,et al. Phosphodiesterase inhibitors suppress proliferation of peripheral blood mononuclear cells and interleukin-4 and -5 secretion by human T-helper type 2 cells. , 1996, Immunopharmacology.
[10] T. van der Poll,et al. Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia. , 1996, The Journal of clinical investigation.
[11] F. Weber,et al. Pentoxifylline, a phosphodiesterase inhibitor, induces immune deviation in patients with multiple sclerosis , 1996, Journal of Neuroimmunology.
[12] P. Barnes,et al. Glucocorticoid resistance in asthma. , 1995, American journal of respiratory and critical care medicine.
[13] C. Page,et al. Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis , 1995, British journal of pharmacology.
[14] J. Veal,et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. , 1995, Journal of medicinal chemistry.
[15] S. Manolagas,et al. Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[16] G. Strassmann,et al. Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages. , 1995, Journal of immunology.
[17] R. van Furth,et al. Effect of xanthine derivates and dexamethasone on Streptococcus pneumoniae-stimulated production of tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 by human leukocytes , 1995, Clinical and diagnostic laboratory immunology.
[18] M. Conti,et al. Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase , 1995, The Journal of Biological Chemistry.
[19] P. Barnes,et al. Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase. , 1995, Molecular pharmacology.
[20] V. Brinkmann,et al. Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets. , 1995, Journal of immunology.
[21] P. Barnes. Cyclic nucleotides and phosphodiesterases and airway function. , 1995, The European respiratory journal.
[22] A. Kagey‐Sobotka,et al. Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors. , 1994, Journal of immunology.
[23] E. F. Smith,et al. Characterization of cAMP-dependent inhibition of LPS-induced TNF alpha production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor. , 1994, International journal of immunopharmacology.
[24] M. Conti,et al. The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase. , 1994, The Journal of biological chemistry.
[25] C. Wanidworanun,et al. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. , 1993, Journal of immunology.
[26] S. Szefler,et al. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. , 1993, Journal of immunology.
[27] J. Beavo,et al. Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. , 1993, The Journal of allergy and clinical immunology.
[28] M. Brown,et al. Immunosuppression by glucocorticoids: inhibition of production of multiple lymphokines by in vivo administration of dexamethasone. , 1993, Cellular immunology.
[29] R. de Waal Malefyt,et al. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. , 1993, Journal of immunology.
[30] S. Najjar,et al. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. , 1993, The Journal of clinical investigation.
[31] M. de Carli,et al. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. , 1993, Journal of immunology.
[32] C. Figdor,et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression , 1991, The Journal of experimental medicine.
[33] A. Abbas,et al. Cellular and Molecular Immunology , 1991 .
[34] R. Koren,et al. 1,25-Dihydroxyvitamin D3 potentiates the decreased response of lymphocytes from atopic subjects to agents that increase intracellular cyclic adenosine monophosphate. , 1990, The Journal of allergy and clinical immunology.
[35] T. Mosmann,et al. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones , 1989, The Journal of experimental medicine.
[36] R. Coffman,et al. The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent. , 1988, Journal of Immunology.
[37] A. Kagey‐Sobotka,et al. Differential efficacy of lymphocyte- and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression. , 1997, The Journal of allergy and clinical immunology.
[38] S. Szefler,et al. Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics. , 1997, American journal of respiratory and critical care medicine.
[39] J. Vincent,et al. Corticosteroids increase blood interleukin-10 levels during cardiopulmonary bypass in men. , 1996, Surgery.
[40] S. Gautam,et al. IL-4 upregulates IL-1-induced chemokine gene expression in bone marrow stromal cells by enhancing NF-kB activation. , 1996, Hematopathology and molecular hematology.
[41] J. Hanifin,et al. Differential inhibitor effects on cyclic adenosine monophosphate-phosphodiesterase isoforms in atopic and normal leukocytes. , 1993, The Journal of laboratory and clinical medicine.
[42] J. D. de Vries,et al. Shifts in interleukin-4 and interferon-gamma production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. , 1991, The Journal of allergy and clinical immunology.