Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico.

[1]  A. Al-Sayegh,et al.  DRUG-PYRIDOXAL PHOSPHATE INTERACTIONS , 1982, Quarterly reviews on drug metabolism and drug interactions.

[2]  H. Webster,et al.  Antimalarial properties of bredinin. Prediction based on identification of differences in human host-parasite purine metabolism. , 1982, The Journal of clinical investigation.

[3]  W. O'Sullivan,et al.  In vitro inhibition of Plasmodium falciparum by pyrazofurin, an inhibitor of pyrimidine biosynthesis de novo. , 1986, Molecular and biochemical parasitology (Print).

[4]  H. Vial,et al.  Quaternary ammonium compounds efficiently inhibit Plasmodium falciparum growth in vitro by impairment of choline transport , 1986, Antimicrobial Agents and Chemotherapy.

[5]  W. Vermaak,et al.  Altered vitamin B6 homeostasis during aminophylline infusion in the beagle dog. , 1990, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[6]  D. Chuang,et al.  Inhibition of the bovine branched-chain 2-oxo acid dehydrogenase complex and its kinase by arylidenepyruvates. , 1990, Biochimica et biophysica acta.

[7]  Kouichi R. Tanaka,et al.  Increased nicotinamide adenine dinucleotide content and synthesis in Plasmodium falciparum-infected human erythrocytes. , 1990, Blood.

[8]  A. Bitonti,et al.  Irreversible inhibition of S-adenosylmethionine decarboxylase in Plasmodium falciparum-infected erythrocytes: growth inhibition in vitro. , 1991, Biochemical pharmacology.

[9]  C. Roberts,et al.  Use of pharmacological agents to implicate a role for phosphoinositide hydrolysis products in malaria gamete formation. , 1993, Biochemical pharmacology.

[10]  D. Chakrabarti,et al.  Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[11]  K. K. Seymour,et al.  Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum. , 1994, Biochemistry.

[12]  P. Marlière,et al.  Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation. , 1994, The EMBO journal.

[13]  I. Sherman,et al.  Inhibition of Plasmodium falciparum lysophospholipase by anti-malarial drugs and sulphydryl reagents , 1994, Parasitology.

[14]  Paul J Thornalley,et al.  Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester. , 1994, Biochemical pharmacology.

[15]  R. Barker,et al.  Inhibition of Plasmodium falciparum malaria using antisense oligodeoxynucleotides. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Ying Zhang,et al.  Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus , 1996, Nature Medicine.

[17]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[18]  T. Triglia,et al.  Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Purification and characterisation of the hexokinase of Plasmodium berghei, a murine malaria parasite. , 1997, Acta veterinaria Hungarica.

[20]  M. V. Flores,et al.  Inhibition of Plasmodium falciparum Proliferationin Vitro by Ribozymes* , 1997, The Journal of Biological Chemistry.

[21]  G. Laslett,et al.  Optical and radiocarbon dating at Jinmium rock shelter in northern Australia , 1998, Nature.

[22]  P. Sarma,et al.  Allopurinol as an additive to quinine in the treatment of acute complicated falciparum malaria. , 1998, The American journal of tropical medicine and hygiene.

[23]  D. Chakrabarti,et al.  Evidence for the shikimate pathway in apicomplexan parasites , 1998, Nature.

[24]  Y. Kitade,et al.  Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities. , 1999, Nucleic acids symposium series.

[25]  C. Wanidworanun,et al.  Antisense oligonucleotides targeting malarial aldolase inhibit the asexual erythrocytic stages of Plasmodium falciparum. , 1999, Molecular and biochemical parasitology.

[26]  N. Suraveratum,et al.  Purification and characterization of Plasmodium falciparum succinate dehydrogenase. , 2000, Molecular and biochemical parasitology.

[27]  P. Rathod,et al.  Potent and Selective Activity of a Combination of Thymidine and 1843U89, a Folate-Based Thymidylate Synthase Inhibitor, against Plasmodium falciparum , 2000, Antimicrobial Agents and Chemotherapy.

[28]  B. Berger.  Antimalarial Activities of Aminooxy Compounds , 2000, Antimicrobial Agents and Chemotherapy.

[29]  S. Dhanasekaran,et al.  Import of host δ-aminolevulinate dehydratase into the malarial parasite: Identification of a new drug target , 2000, Nature Medicine.

[30]  S. Dhanasekaran,et al.  Import of host δ-aminolevulinate dehydratase into the malarial parasite: Identification of a new drug target , 2000, Nature Medicine.

[31]  Bernhard O. Palsson,et al.  Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions , 2000, BMC Bioinformatics.

[32]  N. Surolia,et al.  Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum , 2001, Nature Medicine.

[33]  R. Snow,et al.  The past, present and future of childhood malaria mortality in Africa. , 2001, Trends in parasitology.

[34]  P. Böger,et al.  Very-Long-Chain Fatty Acid Biosynthesis is Inhibited by Cafenstrole, N,N-Diethyl-3-mesitylsulfonyl-1H-1,2,4-triazole-1-carboxamide and Its Analogs , 2001, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[35]  S. Krungkrai,et al.  Mitochondrial NADH dehydrogenase from Plasmodium falciparum and Plasmodium berghei. , 2002, Experimental parasitology.

[36]  K. Katakura,et al.  Inhibition of mitochondrial and plastid activity of Plasmodium falciparum by minocycline , 2002, FEBS letters.

[37]  G. McConkey,et al.  RNA interference (RNAi) inhibits growth of Plasmodium falciparum. , 2002, Molecular and biochemical parasitology.

[38]  B. Palsson,et al.  Metabolic modelling of microbes: the flux-balance approach. , 2002, Environmental microbiology.

[39]  K. Kurokawa,et al.  Plasmodium falciparum Phospholipase C Hydrolyzing Sphingomyelin and Lysocholinephospholipids Is a Possible Target for Malaria Chemotherapy , 2002, The Journal of experimental medicine.

[40]  G. Evans,et al.  Purine-less Death in Plasmodium falciparumInduced by Immucillin-H, a Transition State Analogue of Purine Nucleoside Phosphorylase* , 2002, The Journal of Biological Chemistry.

[41]  S. Müller,et al.  Thioredoxin Reductase Is Essential for the Survival ofPlasmodium falciparum Erythrocytic Stages* , 2002, The Journal of Biological Chemistry.

[42]  S. Rahlfs,et al.  Glutathione S-Transferase of the Malarial Parasite Plasmodium falciparum: Characterization of a Potential Drug Target , 2002, Biological chemistry.

[43]  S. Rahlfs,et al.  Glutathione S-Transferase of the Malarial Parasite Plasmodium falciparum: Characterization of a Potential Drug Target , 2002, Biological chemistry.

[44]  S. Müller,et al.  Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. , 2002, The Biochemical journal.

[45]  E. Liebau,et al.  The glutathione S-transferase from Plasmodium falciparum. , 2002, Molecular and biochemical parasitology.

[46]  Jonathan E. Allen,et al.  Genome sequence of the human malaria parasite Plasmodium falciparum , 2002, Nature.

[47]  Ronald W. Davis,et al.  Functional profiling of the Saccharomyces cerevisiae genome , 2002, Nature.

[48]  S. Shuto,et al.  New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor. , 2002, Journal of medicinal chemistry.

[49]  D. Chakrabarti,et al.  Protein Farnesyltransferase and Protein Prenylation inPlasmodium falciparum * , 2002, The Journal of Biological Chemistry.

[50]  S. Corvaisier,et al.  Inhibition of Transfer Messenger RNA Aminoacylation and trans-Translation by Aminoglycoside Antibiotics* 210 , 2003, The Journal of Biological Chemistry.

[51]  J. Derisi,et al.  The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum , 2003, PLoS biology.

[52]  Kenneth J. Kauffman,et al.  Advances in flux balance analysis. , 2003, Current opinion in biotechnology.

[53]  S. Ralph,et al.  A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum , 2003, Antimicrobial Agents and Chemotherapy.

[54]  J. Le bras,et al.  The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum , 2003, Fundamental & clinical pharmacology.

[55]  H. Bussey,et al.  Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery , 2003, Molecular microbiology.

[56]  P. Crooks,et al.  The Mechanism of l-Canavanine Cytotoxicity: Arginyl tRNA Synthetase as a Novel Target for Anticancer Drug Discovery , 2003, Journal of enzyme inhibition and medicinal chemistry.

[57]  W. Stec,et al.  Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases. , 2003, The Biochemical journal.

[58]  W. Kabsch,et al.  X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Roland Eils,et al.  Gene expression analysis on biochemical networks with the potts spin model , 2003, German Conference on Bioinformatics.

[60]  A. Kaiser,et al.  The efficacy of inhibitors involved in spermidine metabolism in Plasmodium falciparum, Anopheles stephensi and Trypanosoma evansi , 2004, Parasitology Research.

[61]  R. Altman,et al.  Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. , 2004, Genome research.

[62]  M. Perbandt,et al.  Native and Inhibited Structure of a Mu class-related Glutathione S-transferase from Plasmodium falciparum* , 2004, Journal of Biological Chemistry.

[63]  Ney Lemke,et al.  Essentiality and damage in metabolic networks , 2004, Bioinform..

[64]  Ney Lemke,et al.  Essentiality and damage in metabolic networks , 2004, Bioinform..

[65]  D. Söll,et al.  A Unique Hydrophobic Cluster Near the Active Site Contributes to Differences in Borrelidin Inhibition among Threonyl-tRNA Synthetases* , 2005, Journal of Biological Chemistry.

[66]  J. Kotera,et al.  PfPDE 1 , a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum , 2005 .

[67]  A. Boa,et al.  Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase. , 2005, Bioorganic & medicinal chemistry.

[68]  S. Krungkrai,et al.  A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization. , 2005, Biochemistry.

[69]  K. Lüersen,et al.  The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme. , 2005, Molecular and biochemical parasitology.

[70]  R. Baron,et al.  A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[71]  P. Rathod,et al.  High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase* , 2005, Journal of Biological Chemistry.

[72]  C. Ouzounis,et al.  Expansion of the BioCyc collection of pathway/genome databases to 160 genomes , 2005, Nucleic acids research.

[73]  J. Kotera,et al.  PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum. , 2005, The Biochemical journal.

[74]  Timo Heikkilae,et al.  The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. , 2006, Bioorganic & medicinal chemistry letters.

[75]  H. Hosseinzadeh,et al.  In vitro Evaluation of Methylxanthines and Some Antibiotics: Interaction against Staphylococcus aureus and Pseudomonas aeruginosa , 2006 .

[76]  Characterization of the gene encoding glyoxalase II from Leishmania donovani: a potential target for anti-parasite drugs. , 2006, The Biochemical journal.

[77]  Dietmar Schomburg,et al.  Observing local and global properties of metabolic pathways: "load points" and "choke points" in the metabolic networks , 2006, Bioinform..

[78]  K. Anderson,et al.  Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum , 2006, Antimicrobial Agents and Chemotherapy.

[79]  Ney Lemke,et al.  Bioinformatics analysis of mycoplasma metabolism: Important enzymes, metabolic similarities, and redundancy , 2006, Comput. Biol. Medicine.

[80]  H. Ginsburg.  Progress in in silico functional genomics: the malaria Metabolic Pathways database. , 2006, Trends in parasitology.

[81]  Terry K. Smith,et al.  Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei. , 2006, The Biochemical journal.

[82]  H. Mori,et al.  Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection , 2006, Molecular systems biology.

[83]  Ronan M. T. Fleming,et al.  Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0 , 2007, Nature Protocols.

[84]  R. Baron,et al.  Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. , 2007, Biochemistry.

[85]  H. Osago,et al.  Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells* , 2007, Journal of Biological Chemistry.

[86]  Jan Balzarini,et al.  Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth. , 2007, Journal of medicinal chemistry.

[87]  J. Low,et al.  Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology , 2007, Clinical Cancer Research.

[88]  Paul Carroll,et al.  The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis , 2007, Proceedings of the National Academy of Sciences.

[89]  U. Sauer,et al.  Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli , 2007, Molecular systems biology.

[90]  V. Schramm,et al.  Synthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminase. , 2007, Journal of the American Chemical Society.

[91]  Andreas Prlic,et al.  Ensembl 2007 , 2006, Nucleic Acids Res..

[92]  Ronan M. T. Fleming,et al.  Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0 , 2007, Nature Protocols.