BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

[1]  Yilin Cao,et al.  Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[2]  Tao Jin,et al.  Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells , 2019, Nature Communications.

[3]  L. Lv,et al.  Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2. , 2019, Biochemical and biophysical research communications.

[4]  K. Chien,et al.  Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes , 2019, Nature Communications.

[5]  E. Balmayor,et al.  An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo. , 2019, Tissue engineering. Part A.

[6]  Shu Guo,et al.  Synergistic Effects of Controlled-Released BMP-2 and VEGF from nHAC/PLGAs Scaffold on Osteogenesis , 2018, BioMed research international.

[7]  K. Chien,et al.  Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine , 2018, Molecular therapy. Methods & clinical development.

[8]  K. Ulubayram,et al.  VEGF/BMP‐2 loaded three‐dimensional model for enhanced angiogenic and odontogenic potential of dental pulp stem cells , 2018, International endodontic journal.

[9]  Lennart Lindfors,et al.  Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles , 2018, Proceedings of the National Academy of Sciences.

[10]  Yan Hu,et al.  Functionalizing titanium surface with PAMAM dendrimer and human BMP2 gene via layer-by-layer assembly for enhanced osteogenesis. , 2018, Journal of biomedical materials research. Part A.

[11]  A. M. Marcaccini,et al.  Local delivery of strontium ranelate promotes regeneration of critical size bone defects filled with collagen sponge. , 2018, Journal of biomedical materials research. Part A.

[12]  Yinghong Zhou,et al.  The Immunomodulatory Role of BMP-2 on Macrophages to Accelerate Osteogenesis. , 2017, Tissue engineering. Part A.

[13]  M. Ding,et al.  Optimizing combination of vascular endothelial growth factor and mesenchymal stem cells on ectopic bone formation in SCID mice. , 2017, Journal of biomedical materials research. Part A.

[14]  F. Bastami,et al.  3D printed TCP-based scaffold incorporating VEGF-loaded PLGA microspheres for craniofacial tissue engineering. , 2017, Dental materials : official publication of the Academy of Dental Materials.

[15]  Xinquan Jiang,et al.  Evaluation of synergistic osteogenesis between icariin and BMP2 through a micro/meso hierarchical porous delivery system , 2017, International journal of nanomedicine.

[16]  Aldo R Boccaccini,et al.  Regenerating bone with bioactive glass scaffolds: A review of in vivo studies in bone defect models. , 2017, Acta biomaterialia.

[17]  Jinchao Zhang,et al.  Innovative biodegradable poly(L-lactide)/collagen/hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation , 2017, International journal of nanomedicine.

[18]  Feng Chen,et al.  Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects , 2017, International journal of nanomedicine.

[19]  Bin Wu,et al.  Improving osteogenesis of three-dimensional porous scaffold based on mineralized recombinant human-like collagen via mussel-inspired polydopamine and effective immobilization of BMP-2-derived peptide. , 2017, Colloids and surfaces. B, Biointerfaces.

[20]  Yu-Chen Hu,et al.  Enhanced critical-size calvarial bone healing by ASCs engineered with Cre/loxP-based hybrid baculovirus. , 2017, Biomaterials.

[21]  Justin M. Richner,et al.  Modified mRNA Vaccines Protect against Zika Virus Infection , 2017, Cell.

[22]  A. Salem,et al.  A Comparative Study of the Bone Regenerative Effect of Chemically Modified RNA Encoding BMP-2 or BMP-9 , 2017, The AAPS Journal.

[23]  Y. Baran,et al.  Cell Proliferation and Cytotoxicity Assays. , 2016, Current pharmaceutical biotechnology.

[24]  C. Rudolph,et al.  Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats. , 2016, Biomaterials.

[25]  B. Olsen,et al.  Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. , 2016, The Journal of clinical investigation.

[26]  Z. Zhiyong Biomimetically ornamented rapid prototyping fabrication of an apatite-collagen- polycaprolactone composite construct with nano-micro-macro hierarchical structure for large bone defect treatment , 2016 .

[27]  A. Salem,et al.  The oral and craniofacial relevance of chemically modified RNA therapeutics. , 2016, Discovery medicine.

[28]  Yu-Chen Hu,et al.  Healing of osteoporotic bone defects by baculovirus-engineered bone marrow-derived MSCs expressing MicroRNA sponges. , 2016, Biomaterials.

[29]  D. R. Sumner,et al.  Chemically modified RNA activated matrices enhance bone regeneration. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[30]  W. Liu,et al.  The Treatment Efficacy of Bone Tissue Engineering Strategy for Repairing Segmental Bone Defects Under Osteoporotic Conditions. , 2015, Tissue engineering. Part A.

[31]  T. Schlake,et al.  Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

[32]  C. Sotiriou,et al.  RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy , 2015, Breast Cancer Research.

[33]  T. Yen,et al.  Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b. , 2014, Biomaterials.

[34]  M. Moretti,et al.  Donor-matched mesenchymal stem cells from knee infrapatellar and subcutaneous adipose tissue of osteoarthritic donors display differential chondrogenic and osteogenic commitment. , 2014, European cells & materials.

[35]  B. Chang,et al.  Acute Intravenous Injection Toxicity Study of Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 in Rat , 2014, Asian spine journal.

[36]  H. An,et al.  Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery. , 2014, The spine journal : official journal of the North American Spine Society.

[37]  Kathy O. Lui,et al.  Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. , 2014, Cold Spring Harbor perspectives in medicine.

[38]  Ronald A. Li,et al.  Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA , 2013, Cell Research.

[39]  Ronald A. Li,et al.  Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction , 2013, Nature Biotechnology.

[40]  E. Hurwitz,et al.  Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. , 2013, The Journal of bone and joint surgery. American volume.

[41]  W. Dhert,et al.  Non-viral gene therapy for bone tissue engineering , 2013, Biotechnology & genetic engineering reviews.

[42]  Jiang Peng,et al.  Role of mesenchymal stem cells in bone regeneration and fracture repair: a review , 2013, International Orthopaedics.

[43]  Delbert E Day,et al.  Effect of bioactive borate glass microstructure on bone regeneration, angiogenesis, and hydroxyapatite conversion in a rat calvarial defect model. , 2013, Acta biomaterialia.

[44]  G. Im Nonviral gene transfer strategies to promote bone regeneration. , 2013, Journal of biomedical materials research. Part A.

[45]  P. Aspenberg Special Review: Accelerating fracture repair in humans: a reading of old experiments and recent clinical trials. , 2013, BoneKEy reports.

[46]  G. Qi,et al.  Evaluation of isolation methods and culture conditions for rat bone marrow mesenchymal stem cells , 2013, Cytotechnology.

[47]  S. Teoh,et al.  The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application. , 2012, Biomaterials.

[48]  M. Longaker,et al.  A comparative analysis of the osteogenic effects of BMP-2, FGF-2, and VEGFA in a calvarial defect model. , 2012, Tissue engineering. Part A.

[49]  D. Weissman,et al.  Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[50]  G. Niebur,et al.  Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche. , 2012, European cells & materials.

[51]  Bradley K Weiner,et al.  A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. , 2011, The spine journal : official journal of the North American Spine Society.

[52]  J. Rosenecker,et al.  Expression of therapeutic proteins after delivery of chemically modified mRNA in mice , 2011, Nature Biotechnology.

[53]  J. Hauzeur,et al.  Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures , 2010, Stem cells international.

[54]  Mahesh Choolani,et al.  Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects. , 2010, Biomaterials.

[55]  S. Teoh,et al.  Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells , 2009, Stem cells.

[56]  Maryam Hamdollah-Zadeh,et al.  Recombinant human VEGF165b protein is an effective anti-cancer agent in mice. , 2008, European journal of cancer.

[57]  David L Kaplan,et al.  Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo. , 2006, Journal of biomedical materials research. Part A.

[58]  Myron Nevins,et al.  De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. , 2005, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[59]  Safdar N. Khan,et al.  The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications , 2004, Expert opinion on biological therapy.

[60]  R Cancedda,et al.  Repair of large bone defects with the use of autologous bone marrow stromal cells. , 2001, The New England journal of medicine.

[61]  A I Caplan,et al.  Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. , 1995, Bone marrow transplantation.

[62]  Robert C. Wolpert,et al.  A Review of the , 1985 .