BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
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R. Fritsche-Danielson | Jie Yuan | Nevin Witman | Huijing Wang | B. Yan | Wei Fu | Yao Tan | Dong Li | Shanshan Bai | Liqin Lin | Hui-chuan Duan | Zheyuan Yu | M. Wei | Kenneth Chien | Yingnan Geng | Liang Xu
[1] Yilin Cao,et al. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. , 2019, Journal of controlled release : official journal of the Controlled Release Society.
[2] Tao Jin,et al. Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells , 2019, Nature Communications.
[3] L. Lv,et al. Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2. , 2019, Biochemical and biophysical research communications.
[4] K. Chien,et al. Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes , 2019, Nature Communications.
[5] E. Balmayor,et al. An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo. , 2019, Tissue engineering. Part A.
[6] Shu Guo,et al. Synergistic Effects of Controlled-Released BMP-2 and VEGF from nHAC/PLGAs Scaffold on Osteogenesis , 2018, BioMed research international.
[7] K. Chien,et al. Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine , 2018, Molecular therapy. Methods & clinical development.
[8] K. Ulubayram,et al. VEGF/BMP‐2 loaded three‐dimensional model for enhanced angiogenic and odontogenic potential of dental pulp stem cells , 2018, International endodontic journal.
[9] Lennart Lindfors,et al. Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles , 2018, Proceedings of the National Academy of Sciences.
[10] Yan Hu,et al. Functionalizing titanium surface with PAMAM dendrimer and human BMP2 gene via layer-by-layer assembly for enhanced osteogenesis. , 2018, Journal of biomedical materials research. Part A.
[11] A. M. Marcaccini,et al. Local delivery of strontium ranelate promotes regeneration of critical size bone defects filled with collagen sponge. , 2018, Journal of biomedical materials research. Part A.
[12] Yinghong Zhou,et al. The Immunomodulatory Role of BMP-2 on Macrophages to Accelerate Osteogenesis. , 2017, Tissue engineering. Part A.
[13] M. Ding,et al. Optimizing combination of vascular endothelial growth factor and mesenchymal stem cells on ectopic bone formation in SCID mice. , 2017, Journal of biomedical materials research. Part A.
[14] F. Bastami,et al. 3D printed TCP-based scaffold incorporating VEGF-loaded PLGA microspheres for craniofacial tissue engineering. , 2017, Dental materials : official publication of the Academy of Dental Materials.
[15] Xinquan Jiang,et al. Evaluation of synergistic osteogenesis between icariin and BMP2 through a micro/meso hierarchical porous delivery system , 2017, International journal of nanomedicine.
[16] Aldo R Boccaccini,et al. Regenerating bone with bioactive glass scaffolds: A review of in vivo studies in bone defect models. , 2017, Acta biomaterialia.
[17] Jinchao Zhang,et al. Innovative biodegradable poly(L-lactide)/collagen/hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation , 2017, International journal of nanomedicine.
[18] Feng Chen,et al. Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects , 2017, International journal of nanomedicine.
[19] Bin Wu,et al. Improving osteogenesis of three-dimensional porous scaffold based on mineralized recombinant human-like collagen via mussel-inspired polydopamine and effective immobilization of BMP-2-derived peptide. , 2017, Colloids and surfaces. B, Biointerfaces.
[20] Yu-Chen Hu,et al. Enhanced critical-size calvarial bone healing by ASCs engineered with Cre/loxP-based hybrid baculovirus. , 2017, Biomaterials.
[21] Justin M. Richner,et al. Modified mRNA Vaccines Protect against Zika Virus Infection , 2017, Cell.
[22] A. Salem,et al. A Comparative Study of the Bone Regenerative Effect of Chemically Modified RNA Encoding BMP-2 or BMP-9 , 2017, The AAPS Journal.
[23] Y. Baran,et al. Cell Proliferation and Cytotoxicity Assays. , 2016, Current pharmaceutical biotechnology.
[24] C. Rudolph,et al. Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats. , 2016, Biomaterials.
[25] B. Olsen,et al. Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. , 2016, The Journal of clinical investigation.
[26] Z. Zhiyong. Biomimetically ornamented rapid prototyping fabrication of an apatite-collagen- polycaprolactone composite construct with nano-micro-macro hierarchical structure for large bone defect treatment , 2016 .
[27] A. Salem,et al. The oral and craniofacial relevance of chemically modified RNA therapeutics. , 2016, Discovery medicine.
[28] Yu-Chen Hu,et al. Healing of osteoporotic bone defects by baculovirus-engineered bone marrow-derived MSCs expressing MicroRNA sponges. , 2016, Biomaterials.
[29] D. R. Sumner,et al. Chemically modified RNA activated matrices enhance bone regeneration. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[30] W. Liu,et al. The Treatment Efficacy of Bone Tissue Engineering Strategy for Repairing Segmental Bone Defects Under Osteoporotic Conditions. , 2015, Tissue engineering. Part A.
[31] T. Schlake,et al. Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.
[32] C. Sotiriou,et al. RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy , 2015, Breast Cancer Research.
[33] T. Yen,et al. Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b. , 2014, Biomaterials.
[34] M. Moretti,et al. Donor-matched mesenchymal stem cells from knee infrapatellar and subcutaneous adipose tissue of osteoarthritic donors display differential chondrogenic and osteogenic commitment. , 2014, European cells & materials.
[35] B. Chang,et al. Acute Intravenous Injection Toxicity Study of Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 in Rat , 2014, Asian spine journal.
[36] H. An,et al. Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery. , 2014, The spine journal : official journal of the North American Spine Society.
[37] Kathy O. Lui,et al. Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. , 2014, Cold Spring Harbor perspectives in medicine.
[38] Ronald A. Li,et al. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA , 2013, Cell Research.
[39] Ronald A. Li,et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction , 2013, Nature Biotechnology.
[40] E. Hurwitz,et al. Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. , 2013, The Journal of bone and joint surgery. American volume.
[41] W. Dhert,et al. Non-viral gene therapy for bone tissue engineering , 2013, Biotechnology & genetic engineering reviews.
[42] Jiang Peng,et al. Role of mesenchymal stem cells in bone regeneration and fracture repair: a review , 2013, International Orthopaedics.
[43] Delbert E Day,et al. Effect of bioactive borate glass microstructure on bone regeneration, angiogenesis, and hydroxyapatite conversion in a rat calvarial defect model. , 2013, Acta biomaterialia.
[44] G. Im. Nonviral gene transfer strategies to promote bone regeneration. , 2013, Journal of biomedical materials research. Part A.
[45] P. Aspenberg. Special Review: Accelerating fracture repair in humans: a reading of old experiments and recent clinical trials. , 2013, BoneKEy reports.
[46] G. Qi,et al. Evaluation of isolation methods and culture conditions for rat bone marrow mesenchymal stem cells , 2013, Cytotechnology.
[47] S. Teoh,et al. The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application. , 2012, Biomaterials.
[48] M. Longaker,et al. A comparative analysis of the osteogenic effects of BMP-2, FGF-2, and VEGFA in a calvarial defect model. , 2012, Tissue engineering. Part A.
[49] D. Weissman,et al. Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.
[50] G. Niebur,et al. Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche. , 2012, European cells & materials.
[51] Bradley K Weiner,et al. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. , 2011, The spine journal : official journal of the North American Spine Society.
[52] J. Rosenecker,et al. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice , 2011, Nature Biotechnology.
[53] J. Hauzeur,et al. Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures , 2010, Stem cells international.
[54] Mahesh Choolani,et al. Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects. , 2010, Biomaterials.
[55] S. Teoh,et al. Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells , 2009, Stem cells.
[56] Maryam Hamdollah-Zadeh,et al. Recombinant human VEGF165b protein is an effective anti-cancer agent in mice. , 2008, European journal of cancer.
[57] David L Kaplan,et al. Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo. , 2006, Journal of biomedical materials research. Part A.
[58] Myron Nevins,et al. De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. , 2005, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
[59] Safdar N. Khan,et al. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications , 2004, Expert opinion on biological therapy.
[60] R Cancedda,et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. , 2001, The New England journal of medicine.
[61] A I Caplan,et al. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. , 1995, Bone marrow transplantation.
[62] Robert C. Wolpert,et al. A Review of the , 1985 .