Activation of peroxisome proliferator‐activated receptor gamma suppresses mast cell maturation involved in allergic diseases

Background:  Mast cells play a central role in allergic and inflammatory diseases. Several reports indicated role of peroxisome proliferator‐activated receptor gamma (PPARγ) on mast cell function. However, there is no report about the role of PPARγ on differentiation of mast cells from the progenitors. In this study, we investigated the role of PPARγ in regulating bone marrow‐derived mast cell maturation and the therapeutic implications for mast cell‐related diseases such as atopic or contact dermatitis.

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