Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia

[1]  A. Wilkie,et al.  Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. , 2012, American journal of human genetics.

[2]  D. Zarkower,et al.  Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity , 2012, Nature Reviews Genetics.

[3]  C. Cheng,et al.  Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility. , 2012, International journal of andrology.

[4]  C. Degnin,et al.  Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3 , 2011, Molecular biology of the cell.

[5]  H. Scherthan,et al.  SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis , 2011, Journal of Cell Science.

[6]  M. Nagano,et al.  Soluble growth factors stimulate spermatogonial stem cell divisions that maintain a stem cell pool and produce progenitors in vitro. , 2011, Experimental cell research.

[7]  J. Rao,et al.  Identification and characterization of repopulating spermatogonial stem cells from the adult human testis. , 2011, Human reproduction.

[8]  M. Griswold,et al.  The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. , 2010, Developmental cell.

[9]  Janet Rossant,et al.  The role of FGF/Erk signaling in pluripotent cells , 2010, Development.

[10]  Charles C. Guo,et al.  Expression of UTF1 in primary and metastatic testicular germ cell tumors. , 2010, American journal of clinical pathology.

[11]  A. Wilkie,et al.  Missing heritability: paternal age effect mutations and selfish spermatogonia , 2010, Nature Reviews Genetics.

[12]  Deborah Hughes,et al.  Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer , 2010, Nature Genetics.

[13]  Wolfgang Schulze,et al.  Screening for biomarkers of spermatogonia within the human testis: a whole genome approach. , 2010, Human reproduction.

[14]  Matthew S. Cook,et al.  The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency , 2009, Proceedings of the National Academy of Sciences.

[15]  G. McVean,et al.  Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors , 2009, Nature Genetics.

[16]  E. Kremmer,et al.  SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation , 2009, Journal of Cell Science.

[17]  T. Karpova,et al.  Distinct Transcriptional Mechanisms Direct Expression of the Rat Dmrt1 Promoter in Sertoli Cells and Germ Cells of Transgenic Mice1 , 2009, Biology of reproduction.

[18]  Zhuoru Wu,et al.  Spermatogonial Culture Medium: An Effective and Efficient Nutrient Mixture for Culturing Rat Spermatogonial Stem Cells1 , 2009, Biology of reproduction.

[19]  Zuping He,et al.  Spermatogonial stem cells: mouse and human comparisons. , 2009, Birth defects research. Part C, Embryo today : reviews.

[20]  Xiaolei Yin,et al.  Two supporting factors greatly improve the efficiency of human iPSC generation. , 2008, Cell stem cell.

[21]  D. D. de Rooij,et al.  Propagation of bovine spermatogonial stem cells in vitro. , 2008, Reproduction.

[22]  H. L. Roepers-Gajadien,et al.  Expression of the pluripotency marker UTF1 is restricted to a subpopulation of early A spermatogonia in rat testis. , 2008, Reproduction.

[23]  H. Leffers,et al.  Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. , 2008, Human reproduction.

[24]  M. O’Bryan,et al.  Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction. , 2008, Endocrine reviews.

[25]  N. Skakkebaek,et al.  Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report. , 2007, Human reproduction.

[26]  Andreas Makris,et al.  Measuring proliferation in breast cancer: practicalities and applications , 2006, Breast Cancer Research.

[27]  J. Schlessinger,et al.  Nuclear Signaling by Receptor Tyrosine Kinases: The First Robin of Spring , 2006, Cell.

[28]  M. Surani,et al.  The Role of Exogenous Fibroblast Growth Factor‐2 on the Reprogramming of Primordial Germ Cells into Pluripotent Stem Cells , 2006, Stem cells.

[29]  Stefan Wagner,et al.  Pluripotency of spermatogonial stem cells from adult mouse testis , 2006, Nature.

[30]  A. Morin,et al.  Testosterone regulates FGF‐2 expression during testis maturation by an IRES‐dependent translational mechanism , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  H. Niwa,et al.  Oct-3/4 Maintains the Proliferative Embryonic Stem Cell State via Specific Binding to a Variant Octamer Sequence in the Regulatory Region of the UTF1 Locus , 2005, Molecular and Cellular Biology.

[32]  D. Ambrosetti,et al.  Mechanisms underlying differential responses to FGF signaling. , 2005, Cytokine & growth factor reviews.

[33]  R. Brinster,et al.  Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Ralph L Kodell,et al.  Evaluation of Cell Proliferation in Rat Tissues with BrdU, PCNA, Ki-67(MIB-5) Immunohistochemistry and In Situ Hybridization for Histone mRNA , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[35]  J. Gerdes,et al.  The temporal and spatial distribution of the proliferation associated Ki-67 protein during female and male meiosis , 2002, Chromosoma.

[36]  J. Latendresse,et al.  Fixation of Testes and Eyes Using a Modified Davidson's Fluid: Comparison with Bouin's Fluid and Conventional Davidson's Fluid , 2002, Toxicologic pathology.

[37]  K. McElreavey,et al.  Deletions of 9p and the quest for a conserved mechanism of sex determination. , 2000, Molecular genetics and metabolism.

[38]  M. Dym,et al.  Stem Cell Factor/c-kit Up-regulates Cyclin D3 and Promotes Cell Cycle Progression via the Phosphoinositide 3-Kinase/p70 S6 Kinase Pathway in Spermatogonia* , 2000, The Journal of Biological Chemistry.

[39]  Johannes Gerdes,et al.  The Ki‐67 protein: From the known and the unknown , 2000, Journal of cellular physiology.

[40]  D. D. de Rooij,et al.  Differential expression of c-kit in mouse undifferentiated and differentiating type A spermatogonia. , 1999, Endocrinology.

[41]  W. Schulze,et al.  Testicular sperm extraction: comprehensive analysis with simultaneously performed histology in 1418 biopsies from 766 subfertile men. , 1999, Human reproduction.

[42]  C. Grothe,et al.  Localization of fibroblast growth factor 2 (FGF-2) protein and the receptors FGFR 1–4 in normal human seminiferous epithelium , 1998, Histochemistry and Cell Biology.

[43]  K. Boon,et al.  UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra‐embryonic cells , 1998, The EMBO journal.

[44]  M. Bergmann,et al.  The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen. , 1998, Molecular human reproduction.

[45]  I. Kill.  Localisation of the Ki-67 antigen within the nucleolus. Evidence for a fibrillarin-deficient region of the dense fibrillar component. , 1996, Journal of cell science.

[46]  W. Schulze,et al.  The Leydig cell of the human testis —A new member of the diffuse neuroendocrine system , 1993, Cell and Tissue Research.

[47]  Johannes Gerdes,et al.  Monoclonal antibodies against recombinant parts of the Ki‐67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave‐processed formalin‐fixed paraffin sections , 1992, The Journal of pathology.

[48]  S. Nishikawa,et al.  Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. , 1991, Development.

[49]  L. Russell,et al.  Presence and localization of a 30-kDa basic fibroblast growth factor-like protein in rodent testes. , 1991, Endocrinology.

[50]  R. van Driel,et al.  Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes. , 1989, Journal of cell science.

[51]  H Stein,et al.  Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. , 1984, Journal of immunology.

[52]  C. Huckins.  THE SPERMATOGONIAL STEM CELL POPULATION IN ADULT RATS , 1971, Cell and tissue kinetics.

[53]  M. Primig,et al.  Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogonia. , 2012, Reproduction.

[54]  K. Weipoltshammer,et al.  Immunohistochemical expression analysis of Cx43, Cx26, c-KIT and PlAP in contralateral testis biopsies of patients with non-seminomatous testicular germ cell tumor , 2010, Histochemistry and Cell Biology.

[55]  S. Schlatt,et al.  Identification and characterization of spermatogonial subtypes and their expansion in whole mounts and tissue sections from primate testes. , 2008, Methods in molecular biology.

[56]  R I McLachlan,et al.  Histological evaluation of the human testis--approaches to optimizing the clinical value of the assessment: mini review. , 2007, Human reproduction.

[57]  R. Pfundt,et al.  Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. , 2006, Cancer research.

[58]  J. Serth,et al.  Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours , 2005, Journal of Cancer Research and Clinical Oncology.

[59]  N. Skakkebaek,et al.  Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours. , 1994, International journal of andrology.

[60]  C. Fouet,et al.  Sequential changes in the nucleoli of human spermatogonia with special reference to rDNA location and transcription. , 1990, Tissue & cell.

[61]  R. van Driel,et al.  Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase. , 1989, Journal of cell science.

[62]  E. Steinberger,et al.  Radioautography of histologic sections of human testicular tissue. , 1973, Stain technology.