In vivo detection of 2‐hydroxyglutarate in brain tumors by optimized point‐resolved spectroscopy (PRESS) at 7T

To test the efficacy of 7T MRS for in vivo detection of 2‐hydroxyglutarate (2HG) in brain tumors.

[1]  V. Govindaraju,et al.  Proton NMR chemical shifts and coupling constants for brain metabolites , 2000, NMR in biomedicine.

[2]  Omar Abdel-Wahab,et al.  The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. , 2010, Cancer cell.

[3]  Peter Andersen,et al.  Proton T2 relaxation study of water, N‐acetylaspartate, and creatine in human brain using Hahn and Carr‐Purcell spin echoes at 4T and 7T , 2002, Magnetic resonance in medicine.

[4]  S. Provencher.  Estimation of metabolite concentrations from localized in vivo proton NMR spectra , 1993, Magnetic resonance in medicine.

[5]  L. Liau,et al.  Cancer-associated IDH1 mutations produce 2-hydroxyglutarate , 2009, Nature.

[6]  M. van Buchem,et al.  Improved signal to noise in proton spectroscopy of the human calf muscle at 7 T using localized B1 calibration , 2010, Magnetic resonance in medicine.

[7]  Fang Wang,et al.  An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells , 2013, Science.

[8]  Ovidiu C. Andronesi,et al.  Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy , 2012, Science Translational Medicine.

[9]  Abhishek Banerjee,et al.  Measurement of regional variation of GABA in the human brain by optimized point‐resolved spectroscopy at 7 T in vivo , 2014, NMR in biomedicine.

[10]  Hong Wu,et al.  Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy , 2012, Journal of Neuro-Oncology.

[11]  F. Ducray,et al.  IDH1 and IDH2 mutations in gliomas. , 2009, The New England journal of medicine.

[12]  Christian M. Metallo,et al.  Metabolic consequences of oncogenic IDH mutations. , 2015, Pharmacology & therapeutics.

[13]  Darren Price,et al.  Methodology for improved detection of low concentration metabolites in MRS: Optimised combination of signals from multi-element coil arrays , 2014, NeuroImage.

[14]  A. Gryff-Keller,et al.  1H and 13C NMR study of 2‐hydroxyglutaric acid and its lactone , 2002 .

[15]  W. Kaelin,et al.  What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. , 2013, Genes & development.

[16]  Frank M. Sacks,et al.  IDH 1 and IDH 2 Mutations in Gliomas , 2009 .

[17]  E. Maher,et al.  Improvement of resolution for brain coupled metabolites by optimized 1H MRS at 7 T , 2010, NMR in biomedicine.

[18]  S. Nelson,et al.  Advances in ultra-high field MRI for the clinical management of patients with brain tumors. , 2011, Current opinion in neurology.

[19]  Jullie W Pan,et al.  RF shimming for spectroscopic localization in the human brain at 7 T , 2010, Magnetic resonance in medicine.

[20]  Li An,et al.  Detection of glutamate, glutamine, and glutathione by radiofrequency suppression and echo time optimization at 7 tesla , 2015, Magnetic resonance in medicine.

[21]  G B Matson,et al.  A detailed analysis of localized J‐difference GABA editing: theoretical and experimental study at 4 T , 2008, NMR in biomedicine.

[22]  Fang Wang,et al.  Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation , 2013, Science.

[23]  P. Ward,et al.  Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. , 2012, Cancer cell.

[24]  Craig Malloy,et al.  A comparative study of short‐ and long‐TE 1H MRS at 3 T for in vivo detection of 2‐hydroxyglutarate in brain tumors , 2013, NMR in biomedicine.

[25]  Daniel Paech,et al.  Quantification of Tumor Vessels in Glioblastoma Patients Using Time-of-Flight Angiography at 7 Tesla: A Feasibility Study , 2014, PloS one.

[26]  K. Choe,et al.  Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo , 2015, Magnetic resonance in medicine.

[27]  D. Busam,et al.  An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2008, Science.

[28]  Peter Jezzard,et al.  Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations. , 2016, Cancer research.

[29]  K. Uğurbil,et al.  In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T , 2009, Magnetic resonance in medicine.