Deconstructing the form and function of the TCR/CD3 complex.

[1]  P. Love,et al.  Stoichiometry of the murine γδ T cell receptor , 2006, The Journal of experimental medicine.

[2]  L. Chatenoud.  CD3-specific antibodies restore self-tolerance: mechanisms and clinical applications. , 2005, Current opinion in immunology.

[3]  K. Christopher Garcia,et al.  Structure of a γδ T Cell Receptor in Complex with the Nonclassical MHC T22 , 2005, Science.

[4]  Morgan Huse,et al.  Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity , 2005, Nature.

[5]  E. Palmer,et al.  T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes , 2005, The Journal of experimental medicine.

[6]  Gerhard Wagner,et al.  Solution structure of the CD3εδ ectodomain and comparison with CD3εγ as a basis for modeling T cell receptor topology and signaling , 2004 .

[7]  S. Harrison,et al.  Crystal structure of a human CD3-ε/δ dimer in complex with a UCHT1 single-chain antibody fragment , 2004 .

[8]  E. Palmer,et al.  T cell division and death are segregated by mutation of TCRbeta chain constant domains. , 2004, Immunity.

[9]  T. Beddoe,et al.  Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3 , 2004 .

[10]  Mark M Davis,et al.  Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. , 2003, Molecular cell.

[11]  Martin Wiedmann,et al.  The Organizing Principle in the Formation of the T Cell Receptor-CD3 Complex , 2002, Cell.

[12]  B. Fowlkes,et al.  Activation-induced Modification in the CD3 Complex of the γδ T Cell Receptor , 2002, The Journal of experimental medicine.

[13]  J. McCluskey,et al.  The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. , 2002, Structure.

[14]  Balbino Alarcón,et al.  Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation , 2002, Cell.

[15]  P. Love,et al.  Distinct Structure and Signaling Potential of the γδTCR Complex , 2002 .

[16]  E. Reinherz,et al.  Mechanisms Contributing to T Cell Receptor Signaling and Assembly Revealed by the Solution Structure of an Ectodomain Fragment of the CD3ϵγ Heterodimer , 2001, Cell.

[17]  Barbara Hausmann,et al.  A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity , 2000, Nature.

[18]  A. Weiss,et al.  Signal transduction by the TCR for antigen. , 2000, Current opinion in immunology.

[19]  K. Kearse,et al.  Characterization of the epitope on murine T-cell receptor (TCR) alpha proteins recognized by H28-710 monoclonal antibody. , 1999, Hybridoma.

[20]  E. Palmer,et al.  Positive Selection Through a Motif in the αβ T Cell Receptor , 1998 .

[21]  Ellis L. Reinherz,et al.  One of the CD3ε Subunits within a T Cell Receptor Complex Lies in Close Proximity to the Cβ FG Loop , 1998, The Journal of experimental medicine.

[22]  E. Palmer,et al.  A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness. , 1996, Immunity.

[23]  Robyn L. Stanfield,et al.  An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex , 1996, Science.

[24]  C. Geisler,et al.  Distinct Domains of the CD3-γ Chain Are Involved in Surface Expression and Function of the T Cell Antigen Receptor (*) , 1995, The Journal of Biological Chemistry.

[25]  N. Manolios,et al.  The T cell antigen receptor α and β chains interact via distinct regions with CD3 chains , 1994 .

[26]  J. Bonifacino,et al.  Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T‐cell antigen receptor. , 1991, The EMBO journal.

[27]  J. Bonifacino,et al.  Transmembrane helical interactions and the assembly of the T cell receptor complex. , 1990, Science.

[28]  J. Lippincott-Schwartz,et al.  Failure to synthesize the T Cell CD3-ζ chain: Structure and function of a partial T cell receptor complex , 1988, Cell.

[29]  R. Klausner,et al.  Identification of the components of the murine T cell antigen receptor complex , 1985, Cell.

[30]  J. Strominger,et al.  Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunit , 1985, Cell.

[31]  K. Wucherpfennig,et al.  The T cell receptor: critical role of the membrane environment in receptor assembly and function. , 2005, Annual review of immunology.

[32]  D. Engelman.  Electrostatic fasteners hold the T cell receptor-CD3 complex together. , 2003, Molecular cell.

[33]  J. Whisstock,et al.  A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity , 2003 .

[34]  Z Reich,et al.  Ligand recognition by alpha beta T cell receptors. , 1998, Annual review of immunology.

[35]  Y. Chien,et al.  RECOGNITION BY / T CELLS , 1996 .