Macrophages in bone fracture healing: Their essential role in endochondral ossification.

[1]  B. Alman,et al.  Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis , 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  H. M. Jamil,et al.  TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation , 2015, Bone Research.

[3]  M. Barbe,et al.  Role of inflammation in the aging bones. , 2015, Life sciences.

[4]  G. Vunjak‐Novakovic,et al.  Immune modulation as a therapeutic strategy in bone regeneration , 2015, Journal of Experimental Orthopaedics.

[5]  Robert A. Harris.  Spatial, Temporal, and Functional Aspects of Macrophages during “The Good, the Bad, and the Ugly” Phases of Inflammation , 2014, Front. Immunol..

[6]  Roland Steck,et al.  Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification. , 2014, The American journal of pathology.

[7]  M. Sieweke,et al.  Tissue macrophage identity and self‐renewal , 2014, Immunological reviews.

[8]  Nadia J. T. Roumans,et al.  Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses , 2014, PloS one.

[9]  R. Maizels,et al.  Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection , 2014, Immunology and cell biology.

[10]  G. Duda,et al.  Initial immune reaction and angiogenesis in bone healing , 2014, Journal of tissue engineering and regenerative medicine.

[11]  L. Mccauley,et al.  Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone , 2014, Proceedings of the National Academy of Sciences.

[12]  G. Duda,et al.  Initiation and early control of tissue regeneration – bone healing as a model system for tissue regeneration , 2014, Expert opinion on biological therapy.

[13]  N. Van Rooijen,et al.  Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury , 2013, BMC Musculoskeletal Disorders.

[14]  Yi Yin,et al.  Phosphatidylserine-Targeting Antibody Induces M1 Macrophage Polarization and Promotes Myeloid-Derived Suppressor Cell Differentiation , 2013, Cancer Immunology Research.

[15]  N. Rosenthal,et al.  Macrophages are required for adult salamander limb regeneration , 2013, Proceedings of the National Academy of Sciences.

[16]  Navrag B. Singh,et al.  Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans , 2013, Science Translational Medicine.

[17]  Alan D. Lopez,et al.  A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[18]  S. Mundlos,et al.  Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia. , 2012, Bone.

[19]  M. Tamura,et al.  Regulation of osteoblastic differentiation by the proteasome inhibitor bortezomib , 2012, Genes to cells : devoted to molecular & cellular mechanisms.

[20]  Kerry A. Daly,et al.  Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. , 2012, Acta biomaterialia.

[21]  L. Claes,et al.  Fracture healing under healthy and inflammatory conditions , 2012, Nature Reviews Rheumatology.

[22]  Georg N. Duda,et al.  Inflammatory phase of bone healing initiates the regenerative healing cascade , 2011, Cell and Tissue Research.

[23]  D. Hume,et al.  Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[24]  L. Manderson,et al.  Integration of complementary and alternative medicine information and advice in chronic disease management guidelines. , 2011, Australian journal of primary health.

[25]  A. Mantovani,et al.  The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes , 2010, Proceedings of the National Academy of Sciences.

[26]  C. Colnot,et al.  Multiple roles for CCR2 during fracture healing , 2010, Disease Models & Mechanisms.

[27]  J. Roes,et al.  Differential Roles of Macrophages in Diverse Phases of Skin Repair , 2010, The Journal of Immunology.

[28]  A. Doseff,et al.  Monocytes and Macrophages Regulate Immunity through Dynamic Networks of Survival and Cell Death , 2010, Journal of Innate Immunity.

[29]  Georg N Duda,et al.  Differential regulation of blood vessel formation between standard and delayed bone healing , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[30]  G. Duda,et al.  Cellular composition of the initial fracture hematoma compared to a muscle hematoma: A study in sheep , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[31]  S. Badylak,et al.  Macrophage phenotype as a determinant of biologic scaffold remodeling. , 2008, Tissue engineering. Part A.

[32]  Tamara Sztynda,et al.  Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. , 2008, Bone.

[33]  Yongwon Choi,et al.  Osteoimmunology: interactions of the bone and immune system. , 2008, Endocrine reviews.

[34]  S. Kakar,et al.  Enhanced Chondrogenesis and Wnt Signaling in PTH‐Treated Fractures , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[35]  M. Dunning,et al.  beadarray: R classes and methods for Illumina bead-based data , 2007, Bioinform..

[36]  H. Takayanagi.  Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems , 2007, Nature Reviews Immunology.

[37]  M. Harmsen,et al.  Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. , 2007, The American journal of pathology.

[38]  Gordon K. Smyth,et al.  Use of within-array replicate spots for assessing differential expression in microarray experiments , 2005, Bioinform..

[39]  Jean YH Yang,et al.  Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.

[40]  A. Barbul,et al.  Understanding the role of immune regulation in wound healing. , 2004, American journal of surgery.

[41]  A. Tauber.  Metchnikoff and the phagocytosis theory , 2003, Nature Reviews Molecular Cell Biology.

[42]  D. Mosser,et al.  The many faces of macrophage activation , 2003, Journal of leukocyte biology.

[43]  N. Rooijen,et al.  Clodronate liposomes: perspectives in research and therapeutics. , 2002 .

[44]  B. Cronstein,et al.  Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. , 2002, The American journal of pathology.

[45]  S. Shapiro,et al.  Contribution of Monocytes/Macrophages to Compensatory Neovascularization: The Drilling of Metalloelastase-Positive Tunnels in Ischemic Myocardium , 2000, Circulation research.

[46]  N. Haas.  Callusmodulation – Fiktion oder Realität? , 2000, Der Chirurg.

[47]  Kristi Kincaid,et al.  M-1/M-2 Macrophages and the Th1/Th2 Paradigm1 , 2000, The Journal of Immunology.

[48]  Matthew J. Silva,et al.  Growing C57Bl/6 Mice Increase Whole Bone Mechanical Properties by Increasing Geometric and Material Properties , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[49]  Michael C. Ostrowski,et al.  Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1. , 1999, Blood.

[50]  Napoleone Ferrara,et al.  VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation , 1999, Nature Medicine.

[51]  T A Einhorn,et al.  The cell and molecular biology of fracture healing. , 1998, Clinical orthopaedics and related research.

[52]  R. Gamelli,et al.  Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. , 1998, The American journal of pathology.

[53]  I. Shapiro,et al.  Retinoic acid is a major regulator of chondrocyte maturation and matrix mineralization , 1994, Microscopy research and technique.

[54]  Dianqing Wu,et al.  Immunopathology and Infectious Diseases Suppression of PLC 2 by Endotoxin Plays a Role in the Adenosine A 2 A Receptor-Mediated Switch of Macrophages from an Inflammatory to an Angiogenic Phenotype , 2010 .

[55]  Georg N Duda,et al.  Insight into the molecular pathophysiology of delayed bone healing in a sheep model. , 2010, Tissue engineering. Part A.

[56]  E. Alba,et al.  Association between VEGF expression in tumour-associated macrophages and elevated serum VEGF levels in primary colorectal cancer patients. , 2007, Cancer biomarkers : section A of Disease markers.

[57]  S. Gordon.  Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[58]  N. Rooijen,et al.  In vivo" depletion of macrophages by liposome-mediated "suicide". , 2003 .

[59]  TOR Hildebrand,et al.  Quantification of Bone Microarchitecture with the Structure Model Index. , 1997, Computer methods in biomechanics and biomedical engineering.

[60]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[61]  T. Einhorn,et al.  Production of a standard closed fracture in laboratory animal bone , 1984, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[62]  R. Ross,et al.  The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. , 1975, The American journal of pathology.