Recurrent neural networks with composite features for detection of electrocardiographic changes in partial epileptic patients

The aim of this study is to evaluate the diagnostic accuracy of the recurrent neural networks (RNNs) with composite features (wavelet coefficients and Lyapunov exponents) on the electrocardiogram (ECG) signals. Two types of ECG beats (normal and partial epilepsy) were obtained from the MIT-BIH database. The multilayer perceptron neural networks (MLPNNs) were also tested and benchmarked for their performance on the classification of the ECG signals. Decision making was performed in two stages: computing composite features which were then input into the classifiers and classification using the classifiers trained with the Levenberg-Marquardt algorithm. The research demonstrated that the wavelet coefficients and the Lyapunov exponents are the features which well represent the ECG signals and the RNN trained on these features achieved high classification accuracies.

[1]  Elif Derya íbeyli Recurrent neural networks employing Lyapunov exponents for analysis of doppler ultrasound signals , 2008 .

[2]  Paul Schraeder,et al.  Sudden Unexplained Death in Epilepsy: Observations from a Large Clinical Development Program , 1997, Epilepsia.

[3]  T. Tomson,et al.  Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs. Implications for sudden death , 1997, Seizure.

[4]  B. A. Harvey,et al.  Neural network-based EKG pattern recognition , 2002 .

[5]  Lalit Gupta,et al.  Classification of temporal sequences via prediction using the simple recurrent neural network , 2000, Pattern Recognit..

[6]  Karsten Sternickel,et al.  Automatic pattern recognition in ECG time series , 2002, Comput. Methods Programs Biomed..

[7]  A. Casaleggio,et al.  Estimation of Lyapunov exponents of ECG time series—The influence of parameters , 1997 .

[8]  H. Abarbanel,et al.  LYAPUNOV EXPONENTS IN CHAOTIC SYSTEMS: THEIR IMPORTANCE AND THEIR EVALUATION USING OBSERVED DATA , 1991 .

[9]  Pineda,et al.  Generalization of back-propagation to recurrent neural networks. , 1987, Physical review letters.

[10]  Jeffrey M. Hausdorff,et al.  Postictal heart rate oscillations in partial epilepsy. , 1999, Neurology.

[11]  Gustavo Deco,et al.  Dynamics extraction in multivariate biomedical time series , 1998, Biological Cybernetics.

[12]  Yasser M. Kadah,et al.  Study of features based on nonlinear dynamical modeling in ECG arrhythmia detection and classification , 2002, IEEE Transactions on Biomedical Engineering.

[13]  C. Elger,et al.  Cardiac Asystole in Epilepsy: Clinical and Neurophysiologic Features , 2003, Epilepsia.

[14]  G. Jay,et al.  Sudden Unexpected Death Associated with Seizures: Analysis of 66 Cases , 1984, Epilepsia.

[15]  Elif Derya Übeyli,et al.  Detection of electrocardiographic changes in partial epileptic patients using Lyapunov exponents with multilayer perceptron neural networks , 2004, Eng. Appl. Artif. Intell..

[16]  Mohammad Bagher Menhaj,et al.  Training feedforward networks with the Marquardt algorithm , 1994, IEEE Trans. Neural Networks.

[17]  Roberto Battiti,et al.  First- and Second-Order Methods for Learning: Between Steepest Descent and Newton's Method , 1992, Neural Computation.

[18]  J. Gotman,et al.  Heart Rate Changes and ECG Abnormalities During Epileptic Seizures: Prevalence and Definition of an Objective Clinical Sign , 2002, Epilepsia.

[19]  Elif Derya Übeyli,et al.  An expert system for detection of electrocardiographic changes in patients with partial epilepsy using wavelet‐based neural networks , 2005, Expert Syst. J. Knowl. Eng..

[20]  C. Baumgartner,et al.  Electrocardiographic Changes at the Onset of Epileptic Seizures , 2003, Epilepsia.

[21]  Elif Derya Übeyli,et al.  Application of adaptive neuro-fuzzy inference system for detection of electrocardiographic changes in patients with partial epilepsy using feature extraction , 2004, Expert Syst. Appl..

[22]  Claudia Stöllberger,et al.  Cardiorespiratory findings in sudden unexplained/unexpected death in epilepsy (SUDEP) , 2004, Epilepsy Research.

[23]  Ingrid Daubechies,et al.  The wavelet transform, time-frequency localization and signal analysis , 1990, IEEE Trans. Inf. Theory.

[24]  B. H. Blott,et al.  Review of neural network applications in medical imaging and signal processing , 1992, Medical and Biological Engineering and Computing.

[25]  Jeffrey L. Elman,et al.  Finding Structure in Time , 1990, Cogn. Sci..

[26]  Simon Haykin,et al.  Neural Networks: A Comprehensive Foundation , 1998 .

[27]  S. T. Hamde,et al.  Feature extraction from ECG signals using wavelet transforms for disease diagnostics , 2002, Int. J. Syst. Sci..

[28]  T. Tomson,et al.  Heart rate variability in patients with epilepsy 1 Presented in part at the 2nd European Congress of Epileptology, The Hague, September, 1996. 1 , 1998, Epilepsy Research.

[29]  Bidyut Baran Chaudhuri,et al.  Efficient training and improved performance of multilayer perceptron in pattern classification , 2000, Neurocomputing.

[30]  Simon Haykin,et al.  Detection of signals in chaos , 1995, Proc. IEEE.

[31]  Lalit Gupta,et al.  Investigating the prediction capabilities of the simple recurrent neural network on real temporal sequences , 2000, Pattern Recognit..

[32]  G. Cascino,et al.  Incidence and risk factors in sudden unexpected death in epilepsy , 2001, Neurology.

[33]  J. Engel,et al.  Interictal heart rate patterns in partial seizure disorders , 1993, Neurology.