Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model
暂无分享,去创建一个
[1] A. Mahipal. Clinical trials and drug development. , 2014, Cancer control : journal of the Moffitt Cancer Center.
[2] K. Hynynen,et al. Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. , 2012, Human gene therapy.
[3] H. Braak,et al. Phases of Aβ-deposition in the human brain and its relevance for the development of AD , 2002, Neurology.
[4] Jürgen Götz,et al. Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.
[5] E. Masliah,et al. Can Alzheimer disease be prevented by amyloid-β immunotherapy? , 2010, Nature Reviews Neurology.
[6] Tony Wyss-Coray,et al. Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little? , 2009, Neuron.
[7] G. Melacini,et al. In vitro amyloid-β binding and inhibition of amyloid-β self-association by therapeutic albumin. , 2013, Journal of Alzheimer's disease : JAD.
[8] Matthew E. Downs,et al. Transcranial cavitation detection in primates during blood-brain barrier opening-a performance assessment study , 2014, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.
[9] R. Kayed,et al. Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct* , 2007, Journal of Biological Chemistry.
[10] J. Cirrito,et al. Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease , 2014, The Journal of Neuroscience.
[11] Elisa E Konofagou,et al. Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles , 2011, Proceedings of the National Academy of Sciences.
[12] K. Hynynen,et al. MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study , 2013, The Lancet Neurology.
[13] J. Jorquera,et al. Therapeutic albumin binding to remove amyloid-β. , 2012, Journal of Alzheimer's disease : JAD.
[14] M. Hennerici,et al. Clearance of albumin following ultrasound-induced blood–brain barrier opening is mediated by glial but not neuronal cells , 2011, Brain Research.
[15] D. Holtzman,et al. Active and passive immunotherapy for neurodegenerative disorders. , 2008, Annual review of neuroscience.
[16] Joel Alemibola Elegbe. The Need for a Paradigm Shift , 2016, WATER AND SOCIETY.
[17] B. Strooper,et al. The secretases: enzymes with therapeutic potential in Alzheimer disease , 2010, Nature Reviews Neurology.
[18] Rajiv Chopra,et al. Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease , 2010, PloS one.
[19] E. Masliah,et al. Can Alzheimer disease be prevented by amyloid-β immunotherapy? , 2010, Nature Reviews Neurology.
[20] J. Filosa,et al. A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion , 2013, Journal of Neuroinflammation.
[21] Todd E. Golde,et al. Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift , 2011, Neuron.
[22] B. Liu,et al. Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study , 2012, Neurodegenerative Diseases.
[23] D. Selkoe,et al. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide , 2007, Nature Reviews Molecular Cell Biology.
[24] Ralf Seip,et al. Targeted Ultrasound-Mediated Delivery of Nanoparticles: On the Development of a New HIFU-Based Therapy and Imaging Device , 2010, IEEE Transactions on Biomedical Engineering.
[25] Ezzie Hutchinson,et al. Systems neuroscience: The stress of dieting , 2011, Nature Reviews Neuroscience.
[26] B. Winblad,et al. Alzheimer's disease: clinical trials and drug development , 2010, The Lancet Neurology.
[27] G. Schellenberg,et al. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.
[28] Natalia Vykhodtseva,et al. Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. , 2012, Cancer research.
[29] C. Baird,et al. The pilot study. , 2000, Orthopedic nursing.
[30] M. Gallagher,et al. A specific amyloid-β protein assembly in the brain impairs memory , 2006, Nature.
[31] J. Morris,et al. Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease , 2010, Science.
[32] F. LaFerla,et al. Systemic vaccination with anti‐oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg‐AD mice , 2013, Journal of neurochemistry.
[33] Paul A Dayton,et al. Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall. , 2007, The Journal of the Acoustical Society of America.
[34] S. Fowler,et al. Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β , 2013, Brain : a journal of neurology.
[35] K. Hynynen,et al. Multiphoton Imaging of Ultrasound/Optison Mediated Cerebrovascular Effects in vivo , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[36] Elisa E. Konofagou,et al. Optimization of the Ultrasound-Induced Blood-Brain Barrier Opening , 2012, Theranostics.
[37] T. Golde,et al. Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-β Immunotherapy , 2011, The Journal of Neuroscience.
[38] Jürgen Götz,et al. Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease , 2011, Nature Reviews Neuroscience.
[39] B. Sommer,et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[40] Manabu Kinoshita,et al. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[41] Kullervo Hynynen,et al. Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound , 2013, Experimental Neurology.
[42] Elisa E Konofagou,et al. Noninvasive and Transient Blood-Brain Barrier Opening in the Hippocampus of Alzheimer's Double Transgenic Mice Using Focused Ultrasound , 2008, Ultrasonic imaging.