Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea

[1]  L. Zhu,et al.  NLRP3 Inflammasome Mediates Chronic Intermittent Hypoxia-Induced Renal Injury Implication of the Microrna-155/FOXO3a Signaling Pathway , 2020 .

[2]  S. Buch,et al.  Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics , 2020, Autophagy.

[3]  Z. Ran,et al.  Emerging views of mitophagy in immunity and autoimmune diseases , 2020, Autophagy.

[4]  G. van Echten-Deckert,et al.  Neural sphingosine 1‐phosphate accumulation activates microglia and links impaired autophagy and inflammation , 2019, Glia.

[5]  B. Lu,et al.  Mechanisms and roles of mitophagy in neurodegenerative diseases , 2019, CNS neuroscience & therapeutics.

[6]  I. Sirangelo,et al.  Pinocembrin Protects from AGE-Induced Cytotoxicity and Inhibits Non-Enzymatic Glycation in Human Insulin , 2019, Cells.

[7]  W. Yao,et al.  Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF‐κB signaling pathway , 2019, CNS neuroscience & therapeutics.

[8]  G. Yan,et al.  Neuroprotective effects of pinocembrin on ischemia/reperfusion-induced brain injury by inhibiting autophagy. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[9]  Jing Feng,et al.  DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA , 2018, Brain, Behavior, and Immunity.

[10]  Chenyue W. Hu,et al.  Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells. , 2018, Cancer letters.

[11]  S. Chang,et al.  NLRP3 inflammasome mediates chronic intermittent hypoxia‐induced renal injury implication of the microRNA‐155/FOXO3a signaling pathway , 2018, Journal of cellular physiology.

[12]  Heng Wu,et al.  Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy , 2018, Cellular & Molecular Biology Letters.

[13]  L. Kirshenbaum,et al.  Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes. , 2017, Free radical biology & medicine.

[14]  H. Han,et al.  BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells , 2017, Redox biology.

[15]  Kui Chen,et al.  Propofol attenuates intermittent hypoxia induced up-regulation of proinflammatory cytokines in microglia through inhibiting the activation of NF-Bκ/p38 MAPK signalling. , 2017, Folia neuropathologica.

[16]  Xiaoning Han,et al.  Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia , 2017, Brain, Behavior, and Immunity.

[17]  T. Hayakawa,et al.  BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis , 2017, Cell Death & Disease.

[18]  Sheree M. Johnson,et al.  The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment , 2017, Cellular and Molecular Neurobiology.

[19]  J. Ryu,et al.  Mitophagy: a balance regulator of NLRP3 inflammasome activation , 2016, BMB reports.

[20]  B. Bartosch,et al.  Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1 , 2016, Oxidative medicine and cellular longevity.

[21]  Kui Chen,et al.  Intermittent hypoxia reduces microglia proliferation and induces DNA damage in vitro , 2016, Iranian journal of basic medical sciences.

[22]  Jing Ma,et al.  Acute Exercise-Induced Mitochondrial Stress Triggers an Inflammatory Response in the Myocardium via NLRP3 Inflammasome Activation with Mitophagy , 2015, Oxidative medicine and cellular longevity.

[23]  Qiang Li,et al.  The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications , 2016, Molecular Neurobiology.

[24]  M. Geng,et al.  Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway. , 2015, European journal of pharmacology.

[25]  Quan Chen,et al.  Hypoxia activation of mitophagy and its role in disease pathogenesis. , 2015, Antioxidants & redox signaling.

[26]  T. Kanneganti,et al.  Mitochondria: diversity in the regulation of the NLRP3 inflammasome. , 2015, Trends in molecular medicine.

[27]  G. Du,et al.  Pinocembrin Protects the Brain against Ischemia-Reperfusion Injury and Reverses the Autophagy Dysfunction in the Penumbra Area , 2014, Molecules.

[28]  Jie Cao,et al.  Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: the potential roles played by microglia , 2013, Neuropsychiatric disease and treatment.

[29]  M. Frank,et al.  Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. , 2012, Biochimica et biophysica acta.

[30]  Haihua Feng,et al.  In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses. , 2012, International immunopharmacology.

[31]  P. Carmeliet,et al.  Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis , 2012, The Journal of cell biology.

[32]  D. Gozal,et al.  Pathological consequences of intermittent hypoxia in the central nervous system. , 2012, Comprehensive Physiology.

[33]  S. Rikka,et al.  Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover , 2011, Cell Death and Differentiation.

[34]  R. Gottlieb,et al.  Autophagy as a Protective Response to Bnip3-Mediated Apoptotic Signaling in the Heart , 2006, Autophagy.

[35]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[36]  R. Morris.  Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.