Nanoparticles production by supercritical antisolvent precipitation: A general interpretation

Abstract Supercritical antisolvent micronization (SAS) has been used to obtain microparticles of several kind of materials, but the production of nanopar-ticles have been observed and studied in some cases only. This work is focused on the systematic production of nanoparticles using SAS. Weperformed experiments on several compounds and different solvents at selected operating conditions, obtaining nanoparticles with mean diametersranging between 45 and 150nm, thus demonstrating that nanoparticles production is a general characteristic of this process. Moreover, we founda correlation between nanoparticles mean diameter and the reduced concentration of the starting liquid solution that can allow the prediction ofthe mean diameter obtainable at fixed process conditions. Nanoparticles with mean diameters as small as 45nm have been obtained, operatingat 150bar, 40 ◦ C and x CO 2 = 0 . 97; but, even smaller nanoparticles can be obtained operating at higher pressures. The mechanism that producesnanoparticles in supercritical antisolvent precipitation has also been discussed.© 2007 Elsevier B.V. All rights reserved.

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