Building Science-based Medicine at Stanford: Henry Kaplan and the Medical Linear Accelerator, 1948–1975

The hospital is one of the places where people encounter highly advanced science and technology in their daily lives. In the hospital, patients are in contact with a number of scientific innovations and new machines and technologies, more so as computed axial tomography scanners (CAT) and magnetic resonance imaging scanners (MRI) have become indispensable tools for medical diagnosis.1 The instrumentalization of diagnosis and hospital treatment, however, has not been without mixed results. First, the introduction of machines on the bedside, it is often alleged, has distanced physicians from their patients. Patients have found that machine-dominated treatment is given a privileged position and have felt alienated from the doctors’ personal care. On the physicians’ side, their clinical experience has been superseded by information derived from medical instruments. Furthermore, technologies in the hospital have often been associated with the ever-increasing cost of medical care.

[1]  Ginzton El,et al.  The Stanford medical linear accelerator. I. Design and development. , 1957 .

[2]  H. Kaplan,et al.  Extended-field radical radiotherapy in advanced Hodgkin's disease: short-term results of 2 randomized clinical trials. , 1966, Cancer research.

[3]  E. Glatstein,et al.  The value of laparotomy and splenectomy in the staging of Hodgkin's disease , 1969, Cancer.

[4]  E. Brown,et al.  Rockefeller Medicine Men: Medicine and Capitalism in America , 1979 .

[5]  H. Kaplan,et al.  Evidence for an orderly progression in the spread of Hodgkin's disease. , 1966, Cancer research.

[6]  Kaplan Hs,et al.  The Stanford medical linear accelerator. III. Application to clinical problems of radiation therapy. , 1957 .

[7]  H. Kaplan The radical radiotherapy of regionally localized Hodgkin's disease. , 1962, Radiology.

[8]  Steed Pr The Stanford medical linear accelerator. IV. Patient dosimetry. , 1957 .

[9]  D A HOLADAY Where does instrumentation enter into medicine? , 1961, Science.

[10]  Alberto Cambrosio,et al.  Biomedical Platforms: Realigning the Normal and the Pathological in Late-Twentieth-Century Medicine , 2003 .

[11]  H. Kaplan Long-term results of palliative and radical radiotherapy of Hodgkin's disease. , 1966, Cancer research.

[12]  Jacyna Ls The laboratory and the clinic: the impact of pathology on surgical diagnosis in the Glasgow Western Infirmary, 1875-1910. , 1988 .

[13]  C. J. Karzmark LARGE-FIELD SUPERFICIAL ELECTRON THERAPY WITH LINEAR ACCELERATORS. , 1964, The British journal of radiology.

[14]  C. J. Karzmark,et al.  The Stanford medical linear accelerator. II. Installation and physical measurements. , 1959, Radiology.

[15]  C. J. Karzmark,et al.  A technique for large-field, superficial electron therapy. , 1960, Radiology.

[16]  M. D. Schulz The supervoltage story. Janeway Lecture, 1974. , 1975, The American journal of roentgenology, radium therapy, and nuclear medicine.

[17]  E. Glatstein,et al.  Surgical staging of abdominal involvement in unselected patients with Hodgkin's disease. , 1970, Radiology.

[18]  H. Kaplan,et al.  Inhibition by testosterone of radiation-induced lymphoid tumor development in intact and castrate adult male mice. , 1951, Cancer research.

[19]  H. Kaplan Observations on radiation-induced lymphoid tumors of mice. , 1947, Cancer research.

[20]  H. Kaplan Comparative susceptibility of the lymphoid tissues of strain C57 black mice to the induction of lymphoid tumors by irradiation. , 1948, Journal of the National Cancer Institute.

[21]  Gerard L'e. Turner,et al.  Medicine and its technology : an introduction to the history of medical instrumentation , 1985 .

[22]  H. Kaplan,et al.  Indirect induction of lymphomas in irradiated mice. I. Tumor incidence and morphology in mice bearing nonirradiated thymic grafts. , 1956, Cancer research.

[23]  Stuart S. Blume,et al.  Insight and Industry: On the dynamics of technological change in Medicine Cambridge , 1991 .