Expression of osteopontin in non-small cell lung cancer and correlative relation with microvascular density.

BACKGROUND AND OBJECTIVE Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features. METHODS Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment. RESULTS Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000). CONCLUSION OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.

[1]  D. Peng,et al.  Expression of NF-κB and osteopontin of synovial fluid of patients with knee osteoarthritis. , 2013, Asian Pacific journal of tropical medicine.

[2]  Zhenfa Zhang,et al.  Osteopontin knockdown suppresses non‐small cell lung cancer cell invasion and metastasis , 2013, Chinese medical journal.

[3]  E. Raines,et al.  Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin , 2013, Journal of cellular biochemistry.

[4]  G. Weber,et al.  RNA blood levels of osteopontin splice variants are cancer markers , 2013, SpringerPlus.

[5]  K. Samitas,et al.  Osteopontin is increased in the bronchoalveolar lavage fluid and bronchial tissue of smoking asthmatics. , 2013, Cytokine.

[6]  D. Chan,et al.  Association between Osteopontin and EGFR Expression with Clinicopathological Parameters in Hepatocellular Carcinoma. , 2012, The Chinese journal of physiology.

[7]  Lei Du,et al.  Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer , 2012, Clinical Cancer Research.

[8]  L. Ding,et al.  Osteopontin-Enhanced Hepatic Metastasis of Colorectal Cancer Cells , 2012, PloS one.

[9]  Z. Qiu,et al.  Osteopontin is required for angiotensin II-induced migration of vascular smooth muscle cells. , 2012, Die Pharmazie.

[10]  A. Ochiai,et al.  Number of Circulating Endothelial Progenitor Cells and Intratumoral Microvessel Density in Non-small Cell Lung Cancer Patients: Differences in Angiogenic Status between Adenocarcinoma Histologic Subtypes , 2012, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[11]  L. Xing,et al.  Expression and clinical significance of osteopontin in calcified breast tissue. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[12]  U. Ertem,et al.  Serum osteopontin and CD44 levels in lymphoreticular malignancies in children. , 2012, Bratislavske lekarske listy.

[13]  S. Stewart,et al.  Angiogenesis , Metastasis , and the Cellular Microenvironment Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway , 2011 .

[14]  I. Marić,et al.  Osteopontin expression correlates with nuclear factor-κB activation and apoptosis downregulation in clear cell renal cell carcinoma. , 2011, Pathology, research and practice.

[15]  H. Wada,et al.  Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer , 2009, General thoracic and cardiovascular surgery.