Epithelial stem cells: a folliculocentric view.

[1]  M. Herlyn,et al.  Isolation of a novel population of multipotent adult stem cells from human hair follicles. , 2006, The American journal of pathology.

[2]  F. Watt,et al.  Stem cell patterning and fate in human epidermis , 1995, Cell.

[3]  Michael Dean,et al.  Is human patched the gatekeeper of common skin cancers? , 1996, Nature Genetics.

[4]  Jane Q. Nguyen,et al.  Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis , 2005, Nature Medicine.

[5]  Gina A. Taylor,et al.  Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis , 2000, Cell.

[6]  B. Morgan,et al.  Distinct stem cell populations regenerate the follicle and interfollicular epidermis. , 2005, Developmental cell.

[7]  I. Mackenzie.  Relationship between Mitosis and the Ordered Structure of the Stratum Corneum in Mouse Epidermis , 1970, Nature.

[8]  T. Sun,et al.  Epidermal stem cells: properties, markers, and location. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Myers,et al.  Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome , 1996, Science.

[10]  R. Lavker,et al.  Cytotoxic folliculitis in GvHD , 1991, Journal of cutaneous pathology.

[11]  L. Taichman,et al.  Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin , 2001, The EMBO journal.

[12]  D. Elder,et al.  The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. , 1998, Journal of cell science.

[13]  J. Jester,et al.  Hair follicles serve as local reservoirs of skin mast cell precursors. , 2003, Blood.

[14]  F. Watt,et al.  Stem Cell Depletion Through Epidermal Deletion of Rac1 , 2005, Science.

[15]  B. Wainwright,et al.  An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis , 2004, Development.

[16]  C. Potten.  THE EPIDERMAL PROLIFERATIVE UNIT: THE POSSIBLE ROLE OF THE CENTRAL BASAL CELL , 1974, Cell and tissue kinetics.

[17]  M. Grachtchouk,et al.  Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. , 2005, Genes & development.

[18]  T. Sun,et al.  Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles. , 1994, Differentiation; research in biological diversity.

[19]  Yann Barrandon,et al.  Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells , 2001, Cell.

[20]  A. Rütten,et al.  Trichoblastoma and basal cell carcinoma are neoplasms with follicular differentiation sharing the same profile of cytokeratin intermediate filaments. , 1997, The American Journal of dermatopathology.

[21]  Fiona M. Watt,et al.  Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression , 1993, Cell.

[22]  Yaping Liu,et al.  Capturing and profiling adult hair follicle stem cells , 2004, Nature Biotechnology.

[23]  S. Millar,et al.  Molecular mechanisms regulating hair follicle development. , 2002, The Journal of investigative dermatology.

[24]  Yann Barrandon,et al.  Location of stem cells of human hair follicles by clonal analysis , 1994, Cell.

[25]  G. Cotsarelis,et al.  Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen. , 2004, Differentiation; research in biological diversity.

[26]  Amy Li,et al.  Location and phenotype of human adult keratinocyte stem cells of the skin. , 2004, Differentiation; research in biological diversity.

[27]  A. Kligman,et al.  Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis , 1992, The British journal of dermatology.

[28]  Robert M Hoffman,et al.  Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[29]  S. Morrison,et al.  Toward an understanding of the physiological function of Mammalian stem cells. , 2005, Developmental cell.

[30]  Mark C Udey,et al.  Characterization and isolation of stem cell-enriched human hair follicle bulge cells. , 2005, The Journal of clinical investigation.

[31]  D. Whiting.  Histopathologic features of alopecia areata: a new look. , 2003, Archives of dermatology.

[32]  S. Korsmeyer,et al.  Expression of the bcl-2 protooncogene in the cycling adult mouse hair follicle. , 1994, The Journal of investigative dermatology.

[33]  T. Sun,et al.  Upper human hair follicle contains a subpopulation of keratinocytes with superior in vitro proliferative potential. , 1993, The Journal of investigative dermatology.

[34]  H. Pinkus.  CHAPTER 1 – Embryology of Hair , 1958 .

[35]  S. Lyle,et al.  In vitro differences between keratinocyte stem cells and transit-amplifying cells of the human hair follicle. , 2005, The Journal of investigative dermatology.

[36]  E. Fearon,et al.  Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. , 2003, Genes & development.

[37]  Robert M Hoffman,et al.  Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[38]  T. Slaga,et al.  Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen. , 1986, Cancer research.

[39]  Meng Yang,et al.  Nestin expression in hair follicle sheath progenitor cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  I. Moll.  Differential epithelial outgrowth of plucked and microdissected human hair follicles in explant culture , 1996, Archives of Dermatological Research.

[41]  G. Dotto,et al.  Rac1 Up for Epidermal Stem Cells , 2005, Science.

[42]  J. Gordon,et al.  Genetic mosaic analysis indicates that the bulb region of coat hair follicles contains a resident population of several active multipotent epithelial lineage progenitors. , 2002, Developmental biology.

[43]  S. Nishikawa,et al.  Dominant role of the niche in melanocyte stem-cell fate determination , 2002, Nature.

[44]  F. Stenbäck.  Adnexal Participation in Formation of Cutaneous Tumors following Topical Application of 9, 10‐Dimethyl‐Benzanthracene , 1980, Journal of cutaneous pathology.

[45]  C. Kellendonk,et al.  Characterization of an inducible, epidermal‐specific knockout system: Differential expression of lacZ in different Cre reporter mouse strains , 2000 .

[46]  G. Cotsarelis.  Gene expression profiling gets to the root of human hair follicle stem cells. , 2005, The Journal of clinical investigation.

[47]  O. Bernardo,et al.  Summary of North American Hair Research Society (NAHRS)-sponsored Workshop on Cicatricial Alopecia, Duke University Medical Center, February 10 and 11, 2001. , 2003, Journal of the American Academy of Dermatology.

[48]  C. Potten,et al.  Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen. , 1999, The Journal of investigative dermatology.

[49]  B. Doğan,et al.  Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. , 1999, The Journal of investigative dermatology.

[50]  M. Scott,et al.  Basal cell carcinomas in mice overexpressing sonic hedgehog. , 1997, Science.

[51]  Headington Jt.  Tumors of the hair follicle. A review. , 1976 .

[52]  D. Elder,et al.  Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells , 1999, Journal of cutaneous pathology.

[53]  G. Dotto,et al.  Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential. , 1997, The Journal of investigative dermatology.

[54]  R. Morris.  Keratinocyte stem cells: targets for cutaneous carcinogens. , 2000, The Journal of clinical investigation.

[55]  Mayumi Ito,et al.  Label-retaining cells in the bulge region are directed to cell death after plucking, followed by healing from the surviving hair germ. , 2002, The Journal of investigative dermatology.

[56]  Yann Barrandon,et al.  Long-term renewal of hair follicles from clonogenic multipotent stem cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[57]  G. Cotsarelis,et al.  Bioengineering the hair follicle: fringe benefits of stem cell technology. , 2005, Current opinion in biotechnology.

[58]  L. Luo,et al.  Mosaic Analysis with Double Markers in Mice , 2005, Cell.

[59]  R. Tennant,et al.  Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. , 2003, The Journal of investigative dermatology.

[60]  Y. Barrandon,et al.  Three clonal types of keratinocyte with different capacities for multiplication. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[61]  J. Nicolas,et al.  Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors , 2005, Development.

[62]  A. Balmain,et al.  Stem-cell hierarchy in skin cancer , 2003, Nature Reviews Cancer.

[63]  G. Dotto,et al.  p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[64]  R Paus,et al.  The biology of hair follicles. , 1999, The New England journal of medicine.

[65]  E. Fuchs,et al.  Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.

[66]  M. Kashgarian,et al.  Exogen, shedding phase of the hair growth cycle: characterization of a mouse model. , 2002, The Journal of investigative dermatology.

[67]  T. Argyris.  Kinetics of epidermal production during epidermal regeneration following abrasion in mice. , 1976, The American journal of pathology.

[68]  T. Sun,et al.  Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis , 1990, Cell.

[69]  Y. Barrandon,et al.  Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[70]  S. Yuspa,et al.  Reconstitution of hair follicle development in vivo: determination of follicle formation, hair growth, and hair quality by dermal cells. , 1993, The Journal of investigative dermatology.

[71]  S. Lyle,et al.  Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. , 2003, The Journal of investigative dermatology.

[72]  Elaine Fuchs,et al.  Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche , 2004, Cell.

[73]  H. Kamino,et al.  Possible role of the bulge region in the pathogenesis of inflammatory scarring alopecia: lichen planopilaris as the prototype , 2005, Journal of cutaneous pathology.

[74]  J. Arends,et al.  Transforming Growth Factor‐Beta and bcl‐2 Distribution Patterns Distinguish Trichoepithelioma from Basal Cell Carcinoma , 1997, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[75]  I. Mackenzie,et al.  Identification and localization of label-retaining cells in hamster epithelia. , 1984, The Journal of investigative dermatology.

[76]  G. Plewig,et al.  Fetal and adult hair follicle. An immunohistochemical study of anticytokeratin antibodies in formalin-fixed and paraffin-embedded tissue. , 1997, The American Journal of dermatopathology.

[77]  Y. Yoshida,et al.  The human hair follicle: a reservoir of CD40+ B7-deficient Langerhans cells that repopulate epidermis after UVB exposure. , 1998, The Journal of investigative dermatology.