Epidermal Impedance Sensing Sheets for Precision Hydration Assessment and Spatial Mapping

This paper presents a class of hydration monitor that uses ultrathin, stretchable sheets with arrays of embedded impedance sensors for precise measurement and spatially multiplexed mapping. The devices contain miniaturized capacitive electrodes arranged in a matrix format, capable of integration with skin in a conformal, intimate manner due to the overall skin-like physical properties. These “epidermal” systems noninvasively quantify regional variations in skin hydration, at uniform or variable skin depths. Experimental results demonstrate that the devices possess excellent uniformity, with favorable precision and accuracy. Theoretical models capture the underlying physics of the measurement and enable quantitative interpretation of the experimental results. These devices are appealing for applications ranging from skin care and dermatology, to cosmetology and health/wellness monitoring, with the additional potential for combined use with other classes of sensors for comprehensive, quantitative physiological assessment via the skin.

[1]  Jean Luc Lévêque,et al.  Silicon Image Sensor Technology for in vivo Detection of Surfactant-Induced Corneocyte Swelling and Drying , 2005, Dermatology.

[2]  S. Verdier-Sévrain,et al.  Skin hydration: a review on its molecular mechanisms , 2007, Journal of cosmetic dermatology.

[3]  H. Tagami,et al.  Evaluation of the skin surface hydration in vivo by electrical measurement. , 1980, The Journal of investigative dermatology.

[4]  Robert E. Imhof,et al.  Opto-thermal in-vivo skin hydration measurements – a comparison study of different measurement techniques , 2010 .

[5]  Raeed H. Chowdhury,et al.  Epidermal Electronics , 2011, Science.

[6]  Jae Woo Choi,et al.  The influences of skin visco‐elasticity, hydration level and aging on the formation of wrinkles: a comprehensive and objective approach , 2013, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[7]  S. Jee,et al.  Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts. , 1995, The Journal of surgical research.

[8]  Bernard Querleux,et al.  SkinChip®, a new tool for investigating the skin surface in vivo , 2003, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[9]  C. Chow,et al.  Comparison of Skin Hydration Evaluation Sites and Correlations among Skin Hydration, Transepidermal Water Loss, SCORAD Index, Nottingham Eczema Severity Score, and Quality of Life in Patients with Atopic Dermatitis , 2008, American journal of clinical dermatology.

[10]  M. Lindinger,et al.  Prediction of hydration status using multi-frequency bioelectrical impedance analysis during exercise and recovery in horses , 2004 .

[11]  S D Kim,et al.  Evaluation of skin surface hydration in Korean psoriasis patients: a possible factor influencing psoriasis , 2002, Clinical and experimental dermatology.

[12]  T J Ryan,et al.  The effect of mechanical forces (vibration or external compression) on the dermal water content of the upper dermis and epidermis, assessed by high frequency ultrasound. , 2001, Journal of tissue viability.

[13]  Lars Thomassen,et al.  Instrumental assessment of atopic eczema: validation of transepidermal water loss, stratum corneum hydration, erythema, scaling, and edema. , 2006, Journal of the American Academy of Dermatology.

[14]  Chang-Sik Son,et al.  A New Method for Non-Invasive Measurement of Skin in the Low Frequency Range , 2010, Healthcare informatics research.

[15]  V. Raicu,et al.  A quantitative approach to the dielectric properties of the skin. , 2000, Physics in medicine and biology.

[16]  C. Blichmann,et al.  Hydration studies on scaly hand eczema , 1987, Contact dermatitis.

[17]  P. Clarys,et al.  Non‐invasive electrical measurements for the evaluation of the hydration state of the skin: comparison between three conventional instruments ‐ the Comeometer®, the Skicon® and the Nova DPM® , 1999 .

[18]  C. Zouboulis,et al.  Skin aging and sex hormones in women – clinical perspectives for intervention by hormone replacement therapy , 2004, Experimental dermatology.

[19]  F P T Baaijens,et al.  Influence of hydration and experimental length scale on the mechanical response of human skin in vivo, using optical coherence tomography , 2004, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[20]  E. Berardesca,et al.  Comparative study of five instruments measuring stratum corneum hydration (Corneometer CM 820 and CM 825, Skicon 200, Nova DPM 9003, DermaLab). Part I. In vitro , 1999 .

[21]  C. Gabriel,et al.  Electrical conductivity of tissue at frequencies below 1 MHz , 2009, Physics in medicine and biology.

[22]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[23]  A. Baby,et al.  Hydrating effects of moisturizer active compounds incorporated into hydrogels: in vivo assessment and comparison between devices , 2009, Journal of cosmetic dermatology.

[24]  Takayuki Obata,et al.  Measurement of the electrical properties of human skin and the variation among subjects with certain skin conditions. , 2002, Physics in medicine and biology.

[25]  Hachiro Tagami,et al.  High‐frequency conductance measurement of the skin surface hydration state of dry skin using a new probe studded with needle‐form electrodes (MT‐8C) , 1996, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[26]  C.-Y. Guo,et al.  Abnormalities in Stratum Corneum Function in Patients Recovered from Leprosy , 2009, Skin Pharmacology and Physiology.

[27]  A. Siegman Quasi fast Hankel transform. , 1977, Optics letters.

[28]  Alexandru D. P. Papoiu,et al.  Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis. , 2010, Acta dermato-venereologica.

[29]  G. Jemec,et al.  Handbook of non-invasive methods and the skin, second edition , 2006 .

[30]  Don M. Tucker,et al.  Instrumentation for low frequency EIT studies of the human head and its validation in phantom experiments , 2010 .

[31]  E. Clar,et al.  Skin impedance and moisturization , 1975 .

[32]  Woon-Hong Yeo,et al.  Epidermal Differential Impedance Sensor for Conformal Skin Hydration Monitoring , 2012, Biointerphases.

[33]  Franck Giron,et al.  Capacitance imaging of the skin surface , 2006, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[34]  Tapani Lahtinen,et al.  Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer , 2004, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[35]  F. F. Hendriks,et al.  Mechanical behaviour of human epidermal and dermal layers in vivo , 2005 .

[36]  T. Yamamoto,et al.  Electrical properties of the epidermal stratum corneum. , 1973, Medical & biological engineering.

[37]  C. P. Bankston,et al.  Kinetics and transport at AMTEC electrodes. I - The interfacial impedance model. [alkali metal thermoelectric converters] , 1990 .

[38]  Donald Y M Leung,et al.  A multidisciplinary approach to evaluation and treatment of atopic dermatitis. , 2008, Seminars in cutaneous medicine and surgery.

[39]  Hermann Scharfetter,et al.  Fat and hydration monitoring by abdominal bioimpedance analysis: data interpretation by hierarchical electrical modeling , 2005, IEEE Transactions on Biomedical Engineering.

[40]  R. Stoughton,et al.  Regional Variations and the Effect of Hydration and Epidermal Stripping. , 1962, The British journal of dermatology.

[41]  Ada Ferri,et al.  Relationships between skin properties and environmental parameters , 2008, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[42]  S Derler,et al.  Influence of epidermal hydration on the friction of human skin against textiles , 2008, Journal of The Royal Society Interface.

[43]  Koichi Ito,et al.  Development and characteristics of a biological tissue‐equivalent phantom for microwaves , 2001 .

[44]  Harvey N Mayrovitz,et al.  Biophysical measures of skin tissue water: variations within and among anatomical sites and correlations between measures , 2013, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[45]  M. Paye,et al.  Corneometiy measurements to evaluate skin dryness in the modified soap chamber test * , 1995, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[46]  Christopher G. Rylander,et al.  Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT , 2011, Int. J. Biomed. Imaging.

[47]  G Pellacani,et al.  Water sorption-desorption test and moisture accumulation test for functional assessment of atopic skin in children. , 2001, Acta dermato-venereologica.

[48]  S M Kleiner,et al.  Water: an essential but overlooked nutrient. , 1999, Journal of the American Dietetic Association.

[49]  Peng Xu,et al.  Hydration effects on skin microstructure as probed by high-resolution cryo-scanning electron microscopy and mechanistic implications to enhanced transcutaneous delivery of biomacromolecules. , 2010, Journal of pharmaceutical sciences.

[50]  G. Pichan,et al.  Influence of heat-stress induced dehydration on mental functions. , 1986, Ergonomics.

[51]  J. Ring,et al.  Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. , 2000, Acta dermato-venereologica.

[52]  J. Nuutinen,et al.  Variational formulation of open-ended coaxial line in contact with layered biological medium , 1998, IEEE Transactions on Biomedical Engineering.

[53]  Trevor B. Posthumus,et al.  Near-IR spectroscopic imaging for skin hydration: the long and the short of it. , 2002, Biopolymers.

[54]  D. Van Neste In vivo evaluation of unbound water accumulation in stratum corneum. The influence of acute skin irritation induced by sodium laurylsulfate. , 1990 .

[55]  P Helander,et al.  Hydration of human stratum corneum studied in vivo by optothermal infrared spectrometry, electrical capacitance measurement, and evaporimetry. , 1988, Acta dermato-venereologica.

[56]  A. Mak,et al.  In vivo friction properties of human skin , 1999, Prosthetics and orthotics international.

[57]  Jean-Luc Leveque,et al.  Impedance methods for studying skin moisturization , 1983 .

[58]  Sverre Grimnes,et al.  Measuring depth depends on frequency in electrical skin impedance measurements , 1999 .

[59]  Christopher G. Rylander,et al.  Mechanical tissue optical clearing devices: Enhancement of light penetration in ex vivo porcine skin and adipose tissue , 2008, Lasers in surgery and medicine.

[60]  G. K. Khurana Hershey,et al.  Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity. , 2008, The Journal of allergy and clinical immunology.

[61]  H. Benson,et al.  Transdermal drug delivery: penetration enhancement techniques. , 2005, Current drug delivery.

[62]  Frantisek Lopot,et al.  Assessing skin hydration status in haemodialysis patients using terahertz spectroscopy: a pilot/feasibility study. , 2008, Physics in medicine and biology.

[63]  Y Yeshurun,et al.  Strontium hexaferrite nanomagnets suspended in a cosmetic preparation: a convenient tool to evaluate the biological effects of surface magnetism on human skin , 2010, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[64]  P. Clarys,et al.  In vitro calibration of the capacitance method (Corneometer CM 825) and conductance method (Skicon‐200) for the evaluation of the hydration state of the skin , 1997, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.