Annals of Clinical Microbiology and Antimicrobials 23 Years of the Discovery of Helicobacter Pylori: Is the Debate Over?

The Gram negative curved bacillus H. pylori has become the prize bug of all times. Barry Marshall and Robin Warren the two discoverers of this organism have been awarded with this year's Nobel Prize. The Nobel committee at the Karolinska Institute of Sweden has selected this paradigm shift discovery of 1982 as the most impacting in medical sciences. This award has surprised many as the Nobel assembly has selected this 'Robert Koch styled medical detective work' for the prize as compared to many outstanding basic research stories on the waitlist. This editorial briefly touches the significant impact of H. pylori on gastroduodenal management and the path forward as the bug has become quite controversial in recent times.

[1]  M. Blaser,et al.  Inverse relationship between gastric colonization of Helicobacter pylori and diarrheal illnesses in children: results of a population-based cross-sectional study. , 2000, The Journal of infectious diseases.

[2]  B E Dunn,et al.  Helicobacter pylori , 1997, Clinical microbiology reviews.

[3]  A B West,et al.  An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. , 1998, Cancer research.

[4]  C. de Martel,et al.  Helicobacter pylori infection and the risk of development of esophageal adenocarcinoma. , 2005, The Journal of infectious diseases.

[5]  D. Graham.  Helicobacter pylori, GERD, NSAIDs, and Cancer: Where We Really Stand , 1999, American Journal of Gastroenterology.

[6]  C. Brändén,et al.  Antibacterial peptide from H. pylori , 1999, Nature.

[7]  Martin J Blaser,et al.  An endangered species in the stomach. , 2005, Scientific American.

[8]  N. Ahmed,et al.  Helicobacter pylori and gastroduodenal pathology: New threats of the old friend , 2005, Annals of Clinical Microbiology and Antimicrobials.

[9]  B. Marshall,et al.  Attempt to fulfil Koch's postulates for pyloric Campylobacter , 1985, The Medical journal of Australia.

[10]  B. Marshall,et al.  UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION , 1984, The Lancet.

[11]  G. Falk,et al.  Helicobacter pylori and gastroesophageal reflux disease: the bug may not be all bad , 1998, American Journal of Gastroenterology.

[12]  C. Mcnulty,et al.  The significance of cagA + Helicobacter pylori in reflux oesophagitis , 2001, Gut.