Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling.

[1]  K. Baek,et al.  Cellular Functions of High-Temperature Requirement Factor A4 in Placenta , 2023, Cells.

[2]  R. Gesuita,et al.  HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker? , 2022, Diagnostics.

[3]  Kiyoko Kato,et al.  Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts. , 2022, Journal of pharmacological sciences.

[4]  A. Paquette,et al.  The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis , 2022, Current Environmental Health Reports.

[5]  T. Cindrova-Davies,et al.  Human placental development and function. , 2022, Seminars in cell & developmental biology.

[6]  P. Dini,et al.  Estrogens Regulate Placental Angiogenesis in Horses , 2021, International journal of molecular sciences.

[7]  X. Shang,et al.  Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway , 2021, Evidence-based complementary and alternative medicine : eCAM.

[8]  E. Albrecht,et al.  Novel Technologies for Target Delivery of Therapeutics to the Placenta during Pregnancy: A Review , 2021, Genes.

[9]  Y. Jacquemyn,et al.  MicroRNAs targeting VEGF are related to vascular dysfunction in preeclampsia , 2021, Bioscience reports.

[10]  A. Heazell,et al.  Stillbirths preceded by reduced fetal movements are more frequently associated with placental insufficiency: a retrospective cohort study , 2021, Journal of perinatal medicine.

[11]  S. Gupta,et al.  Placental mitochondrial function as a driver of angiogenesis and placental dysfunction , 2021, Biological chemistry.

[12]  Yulong Yin,et al.  Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients. , 2021, Advances in nutrition.

[13]  Yulong Yin,et al.  Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway , 2021, Redox biology.

[14]  Xuliang Deng,et al.  HtrA3‐Mediated Endothelial Cell–Extracellular Matrix Crosstalk Regulates Tip Cell Specification , 2021, Advanced Functional Materials.

[15]  B. Bussolati,et al.  Angiogenic Properties of Placenta-Derived Extracellular Vesicles in Normal Pregnancy and in Preeclampsia , 2021, International journal of molecular sciences.

[16]  Kiyoko Kato,et al.  Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts , 2021, International journal of molecular sciences.

[17]  S. Kwiatkowski,et al.  Molecular Pathways of Cellular Senescence and Placental Aging in Late Fetal Growth Restriction and Stillbirth , 2021, International journal of molecular sciences.

[18]  Zhiqiang Li,et al.  Interleukin-6 released by oral lichen planus myofibroblasts promotes angiogenesis , 2021, Experimental and therapeutic medicine.

[19]  P. Shaw,et al.  The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD , 2021, Vessel plus.

[20]  K. Schalper,et al.  IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy , 2020, Clinical Cancer Research.

[21]  Neelam Sharma,et al.  Computer-aided prediction and design of IL-6 inducing peptides: IL-6 plays a crucial role in COVID-19 , 2020, Briefings Bioinform..

[22]  K. Satyamoorthy,et al.  Interleukin-6–mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors , 2020, The Journal of Biological Chemistry.

[23]  G. Coata,et al.  First trimester HtrA1 maternal plasma level and spontaneous preterm birth , 2020, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[24]  G. Coata,et al.  Association between first trimester plasma htra1 level and subsequent preeclampsia: A possible early marker? , 2019, Pregnancy hypertension.

[25]  R. Lim,et al.  HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia , 2019, Scientific Reports.

[26]  G. Lovrecz,et al.  High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  G. Nie,et al.  Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin. , 2019, Placenta.

[28]  A. Kumawat,et al.  Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells , 2018, Cell Communication and Signaling.

[29]  O. Schilling,et al.  N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[30]  F. Xing,et al.  Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions. , 2018, Molecular medicine reports.

[31]  T. Horvath,et al.  Type I interferons instigate fetal demise after Zika virus infection , 2018, Science Immunology.

[32]  X. Fang,et al.  CRH promotes human colon cancer cell proliferation via IL‐6/JAK2/STAT3 signaling pathway and VEGF‐induced tumor angiogenesis , 2017, Molecular carcinogenesis.

[33]  Y. Li,et al.  Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood , 2017, Scientific Reports.

[34]  F. Bazer,et al.  Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy, , 2016, Biology of Reproduction.

[35]  G. Nie,et al.  High levels of HtrA4 observed in preeclamptic circulation drastically alter endothelial gene expression and induce inflammation in human umbilical vein endothelial cells , 2016, Placenta.

[36]  Y. Li,et al.  Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction. , 2015, The Journal of clinical endocrinology and metabolism.

[37]  S. Raha,et al.  Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling , 2015, BioMed research international.

[38]  Shuwei Wang,et al.  The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review). , 2014, International journal of oncology.

[39]  H. Kurahashi,et al.  Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia. , 2012, Placenta.

[40]  N. Gomez‐Lopez,et al.  Interleukin-6 in pregnancy and gestational disorders. , 2012, Journal of reproductive immunology.

[41]  A. Tibary,et al.  Effect of tocopherol supplementation during last trimester of pregnancy on mRNA abundances of interleukins and angiogenesis in ovine placenta and uterus , 2012, Reproductive Biology and Endocrinology.

[42]  M. Neurath,et al.  IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. , 2011, Cytokine & growth factor reviews.

[43]  P. Caposio,et al.  IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin. , 2011, Blood.

[44]  E. Wallace,et al.  Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia. , 2010, The Journal of clinical endocrinology and metabolism.

[45]  Hua Yu,et al.  IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway , 2009, The Journal of experimental medicine.

[46]  Y. Asmann,et al.  Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion. , 2008, American journal of obstetrics and gynecology.

[47]  B. Huppertz,et al.  Prediction of preeclampsia - a workshop report. , 2008, Placenta.

[48]  E. Hurt,et al.  The role of IL-6 and STAT3 in inflammation and cancer. , 2005, European journal of cancer.

[49]  K. Baek,et al.  Expression of angiogenesis‐ and apoptosis‐related genes in chorionic villi derived from recurrent pregnancy loss patients , 2003, Molecular reproduction and development.

[50]  K. Baek,et al.  Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loss patients. , 2002, Reproduction, fertility, and development.

[51]  M. Mitchell,et al.  Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy in women. , 2002, Placenta.

[52]  James J. Walker,et al.  Pre-eclampsia , 2000, The Lancet.

[53]  N. Desai,et al.  Evaluation of the effect of interleukin-6 and human extracellullar matrix on embryonic development. , 1999, Human reproduction.

[54]  W. Gong,et al.  Human recombinant monocyte chemotactic protein and other c‐c chemokines bind and induce directional migration of dendritic cells in vitro , 1996, Journal of leukocyte biology.

[55]  J. Hustin,et al.  Distribution of interleukin-6 in maternal and embryonic tissues during the first trimester. , 1996, Molecular human reproduction.

[56]  G. Neufeld,et al.  Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor (*) , 1996, The Journal of Biological Chemistry.

[57]  S. Handwerger,et al.  Ontogeny of the expression and regulation of interleukin-6 (IL-6) and IL-1 mRNAs by human trophoblast cells during differentiation in vitro. , 1995, Journal of Endocrinology.

[58]  T. Springer,et al.  Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[59]  T. Hirano,et al.  Production of interleukin-6 by normal human trophoblast. , 1990, Placenta.

[60]  L. Sachs,et al.  Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.