Analysis of the neurotoxic plasticizer n-butylbenzenesulfonamide by gas chromatography combined with accurate mass selected ion monitoring.

The plasticizer, n-butylbenzenesulfonamide (NBBS), is reported to be neurotoxic when inoculated intracisternally or intraperitoneally into rabbits. Because NBBS is commonly used in the production of polyamide (nylon) plastics and is soluble in water, the disposal of NBBS-containing plastics in landfill sites could result in NBBS appearing in the leachate. Further, NBBS could also be leached from packaging into their contents. To allow us to examine the risks posed by NBBS in the environment, we have developed a quantitative assay for this compound. The assay employs a one-step extraction into dichloromethane followed by gas chromatography with accurate mass selected ion recording. The assay incorporates [13C6]NBBS as an internal standard to allow precise quantitation, and four separate ion chromatograms are recorded. NBBS was found in some Australian domestic solidwaste landfill leachate (from less than 0.3 to 94.6 ng/mL), but ground water in the vicinity of a landfill had only trace quantities of NBBS. NBBS was also quantitated in some bottled and cask wines, and levels varied from not detected to 2.17 ng/mL (n = 14). Additional studies are required to assess the public health risks associated with the use of NBBS as a plasticizer.

[1]  R. Yanagihara,et al.  Preliminary Observations on the in Vitro Toxicity of N‐Butylbenzenesulfonamide: A Newly Discovered Neurotoxin , 1993, Annals of the New York Academy of Sciences.

[2]  Tanya L. Russell.  Environmental risk factors in Parkinson's disease , 1992 .

[3]  L. Whalley.  Risk factors in Alzheimer's disease. , 1991, BMJ.

[4]  R. Garruto,et al.  N-butylbenzenesulphonamide, a novel neurotoxic plasticising agent , 1990, The Lancet.

[5]  F. Ventura,et al.  Occurrence of industrial organic pollution in a groundwater supply: screening, monitoring and evaluation of treatment processes , 1989 .

[6]  L. Castle,et al.  Migration of plasticizers from printing inks into foods. , 1989, Food additives and contaminants.

[7]  R. Rubin,et al.  What price progress?: An update on vinyl plastic blood bags , 1989 .

[8]  D. Perl,et al.  RISING MORTALITY FROM MOTONEURON DISEASE IN THE USA, 1962-84 , 1989, The Lancet.

[9]  J Gilbert,et al.  Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging. , 1988, Food additives and contaminants.

[10]  L. Castle,et al.  Migration from plasticized films into foods. 2. Migration of di-(2-ethylhexyl)adipate from PVC films used for retail food packaging. , 1987, Food additives and contaminants.

[11]  P. Spencer.  Guam ALS/Parkinsonism-Dementia: A Long-Latency Neurotoxic Disorder Caused by “Slow Toxin(s)” in Food? , 1987, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[12]  J. Albaigés,et al.  Organic indicators of groundwater pollution by a sanitary landfill , 1986 .

[13]  B. Henderson,et al.  A case-control study of amyotrophic lateral sclerosis. , 1986, American journal of epidemiology.

[14]  R. Labow,et al.  Distribution of di(2-ethylhexyl) phthalate and products in blood and blood components. , 1986, Environmental health perspectives.

[15]  A. Noordsij,et al.  The quality of drinking water prepared from bank-filtered river water in the Netherlands , 1985 .

[16]  C. H. Ward,et al.  A predictive laboratory study of trace organic contamination of groundwater: Preliminary results , 1984 .

[17]  L. Sheldon,et al.  Sources and movement of organic chemicals in the Delaware River , 1979 .

[18]  R. Rubin,et al.  Plasticizers from Plastic Devices: Extraction, Metabolism, and Accumulation by Biological Systems , 1970, Science.