Pharmaceuticals and Personal Care Products in the Environment: Overarching Issues and Overview

The pharmaceutical and consumer healthcare industries recognize the concerns raised by stakeholders regarding the presence of pharmaceuticals in the environment (PIE) and personal care products in the environment (PCPE). The major source of pharmaceuticals entering the environment is via patient excretion following use of medicine that is taken to prevent, cure or alleviate a medical condition. A comparatively smaller contribution to PIE stems from emissions resulting from the manufacturing process and from improper disposal of medications. The major source of personal care products entering the environment is via use of products and removal from the body during bathing activities.

[1]  L. Migliore,et al.  Effect of sulphadimethoxine contamination on barley (Hordeum distichum L., Poaceae, Liliposida) , 1996 .

[2]  J. Mintzer,et al.  Anticholinergic side-effects of drugs in elderly people , 2000, Journal of the Royal Society of Medicine.

[3]  Carola Hanisch,et al.  Is extended producer responsibility effective? , 2000, Environmental science & technology.

[4]  W. Butte,et al.  Photochemical degradation of nitrated musk compounds , 1999 .

[5]  V. Hormazábal,et al.  Persistence of antibacterial agents in marine sediments , 1995 .

[6]  D. Kennedy,et al.  Regulatory problems caused by contamination, a frequently overlooked cause of veterinary drug residues. , 2000, Journal of chromatography. A.

[7]  B. Weiss A Risk Assessment Perspective On the Neurobehavioral Toxicity of Endocrine Disruptors , 1998, Toxicology and industrial health.

[8]  Christian Zwiener,et al.  Oxidative treatment of pharmaceuticals in water , 2000 .

[9]  J. Olney,et al.  Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain. , 2000, Environmental health perspectives.

[10]  Ettore Zuccato,et al.  Presence of therapeutic drugs in the environment , 2000, The Lancet.

[11]  Christian G. Daughton,et al.  Illicit Drugs in Municipal Sewage: Proposed New Nonintrusive Tool to Heighten Public Awareness of Societal Use of Illicit-Abused Drugs and Their Potential for Ecological Consequences , 2001 .

[12]  D. M. Butler,et al.  Release of Ca(2+) from intracellular stores and entry of extracellular Ca(2+) are involved in sea squirt sperm activation. , 1999, Developmental biology.

[13]  R. Shapiro,et al.  Environmental trace analysis of organics in water by glass capillary column chromatography and ancillary techniques. Products of ozonolysis. , 1977, Journal of chromatography.

[14]  L. Migliore,et al.  Phytotoxicity to and uptake of flumequine used in intensive aquaculture on the aquatic weed, Lythrum salicaria L. , 2000, Chemosphere.

[15]  John P. Sumpter,et al.  Long-Term Temporal Changes in the Estrogenic Composition of Treated Sewage Effluent and Its Biological Effects on Fish , 2000 .

[16]  S. Dyer,et al.  Assessments of Chemical Mixtures via Toxicity Reference Values Overpredict Hazard to Ohio Fish Communities , 2000 .

[17]  L L Needham,et al.  Levels of seven urinary phthalate metabolites in a human reference population. , 2000, Environmental health perspectives.

[18]  Robert S. Boethling,et al.  Screening for persistent organic pollutants: Techniques to provide a scientific basis for POPs criteria in international negotiations , 1999 .

[19]  B. Ross,et al.  Pentobarbital Found in Ground Water , 1993 .

[20]  M. van den Berg,et al.  2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity? , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[21]  G. R. Barrie Webster,et al.  Hormonally Active Agents in the Environment , 2001 .

[22]  M. Bamdad,et al.  Identification of a multidrug resistance‐like system in Tetrahymena pyriformis: evidence for a new detoxication mechanism in freshwater ciliates , 1999, FEBS letters.

[23]  D. Ferber Superbugs on the Hoof? , 2000, Science.

[24]  Z. H. Li,et al.  A light-inactivated antibiotic. , 2000, Journal of medicinal chemistry.

[25]  Michael Zschiesche,et al.  Induction of P‐glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction , 2000, Clinical pharmacology and therapeutics.

[26]  T. Ternes,et al.  Pharmaceuticals and personal care products in the environment: agents of subtle change? , 1999, Environmental health perspectives.

[27]  Snyder,et al.  Cytochrome P450 enzymes in aquatic invertebrates: recent advances and future directions. , 2000, Aquatic toxicology.

[28]  Erin M. Snyder,et al.  Pharmaceuticals and personal care products in the waters of Lake Mead, Nevada , 2001 .

[29]  D. Epel,et al.  Multidrug-Multixenobiotic Transporters and Their Significance with Respect to Environmental Levels of Pharmaceuticals and Personal Care Products , 2001 .

[30]  Roy S. Thompson,et al.  Intermittent Exposure of Fish to Estradiol , 2000 .

[31]  A. Hofman,et al.  Maternal Use of Antiepileptic Drugs and the Risk of Major Congenital Malformations: A Joint European Prospective Study of Human Teratogenesis Associated with Maternal Epilepsy , 1997, Epilepsia.

[32]  J. Lary,et al.  Teratology Society Public Affairs Committee position paper: developmental toxicity of endocrine disruptors to humans. , 1999, Teratology.