Interactions between LHRH, sex steroids and inhibin in the control of LH and FSH secretion

Using anterior pituitary cells obtained from adult male rats, 17β-estradiol stimulated both spontaneous and LHRH-induced LH and FSH secretion. After in vivo administration, estrogens showed inhibitory or stimulatory effects on gonadotropin secretion, the effect being dose- and time-dependent. Contrary to estrogens, androgens had differential effects at the anterior pituitary level: they inhibited LH but stimulated FSH secretion. These in vitro data were confirmed by in vivo experiments using anti-androgens. Sertoli cell culture medium was found to be a potent inhibitor of spontaneous FSH secretion while no effect was detected on LH release. When the gonadotropin response to LHRH was studied, Sertoli cell culture medium was a more potent inhibitor of FSH than LH release although clear inhibition of LHRH-induced LH release did occur.

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