Aspirine et grossesse

L’aspirine, inhibiteur de la cyclo-oxygenase, est desormais prescrite dans un certain nombre de pathologies ou il existe une anomalie de la production des prostaglandines, comme la maladie hypertensive gravidique. Il ressort des differentes etudes que la prescription de faibles doses d’aspirine peut prevenir la recidive ou l’apparition d’une pre-eclampsie ou d’un retard de croissance intra-uterin, en cas d’antecedents similaires, d’une anomalie du doppler uterin ou d’un syndrome des antiphospholipides. Le traitement doit etre debute le plus tot possible, etre adapte en fonction du temps de saignement et poursuivi si possible jusqu’a 36 semaines d’amenorrhee.

[1]  C. Damsky,et al.  Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? , 1997, The Journal of clinical investigation.

[2]  T. Cadoux-Hudson,et al.  Delayed paraplegia following spinal anaesthesia , 1996, Anaesthesia.

[3]  W. F. O'brien,et al.  The effect of magnesium sulfate on bleeding time in pregnancy. , 1995, American journal of obstetrics and gynecology.

[4]  K. Leveno,et al.  Randomized Comparison of General and Regional Anesthesia for Cesarean Delivery in Pregnancies Complicated by Severe Preeclampsia , 1995, Obstetrics and gynecology.

[5]  B. Sibai,et al.  Low-dose aspirin in nulliparous women: Safety of continuous epidural block and correlation between bleeding time and maternal-neonatal bleeding complications , 1995 .

[6]  G. Y. Wong,et al.  Preoperative Antiplatelet Therapy Does Not Increase the Risk of Spinal Hematoma Associated with Regional Anesthesia , 1995, Anesthesia and analgesia.

[7]  V. Fuster,et al.  Aspirin and other platelet-active drugs. The relationship among dose, effectiveness, and side effects. , 1989, Chest.

[8]  J. Vermylen,et al.  Anticoagulants and Spinal‐Epidural Anesthesia , 1994, Anesthesia and analgesia.

[9]  C. Patrono.  Aspirin as an antiplatelet drug. , 1994, The New England journal of medicine.

[10]  M. Pillai.  Platelets and pregnancy , 1993, British journal of obstetrics and gynaecology.

[11]  J. Wildsmith,et al.  Aspirin, bleeding time and central neural block. , 1993, British journal of anaesthesia.

[12]  Jeffrey S. Ginsberg,et al.  Use of antithrombotic agents during pregnancy. , 1992, Chest.

[13]  H. Wallenburg,et al.  Aspirin in pregnancy , 1992 .

[14]  B. Sibai,et al.  Anesthetic modification of hemodynamic and neuroendocrine stress responses to cesarean delivery in women with severe preeclampsia. , 1991, Anesthesia and analgesia.

[15]  S. Uzan,et al.  Prevention of fetal growth retardation with low-dose aspirin: findings of the EPREDA trial , 1991, The Lancet.

[16]  E. Crosby.  Obstetrical anaesthesia for patients with the syndrome of haemolysis, elevated liver enzymes and low platelets , 1991, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[17]  K. Offord,et al.  Does preoperative antiplatelet therapy increase the risk of hemorrhagic complications associated with regional anesthesia , 1990 .

[18]  J. Levin,et al.  A Critical Reappraisal of the Bleeding Time* , 1990, Seminars in thrombosis and hemostasis.

[19]  B. Sibai,et al.  Correlation Between Bleeding Times and Platelet Counts in Women With Preeclampsia Undergoing Cesarean Section , 1990 .

[20]  R. S. Bramwell,et al.  Severe Preeclampsia: Hemodynamic Effects of Lumbar Epidural Anesthesia , 1986, Anesthesia and analgesia.

[21]  J. Kelton,et al.  A Platelet Function Defect in Preeclampsia , 1985, Obstetrics and gynecology.

[22]  N. Vaisrub,et al.  Bleeding Time and Nerve Blocks After Aspirin , 1984, Regional Anesthesia & Pain Medicine.

[23]  A. Hollmen,et al.  Lumbar Epidural Analgesia to Improve Intervillous Blood Flow During Labor in Severe Preeclampsia , 1982, Obstetrics and gynecology.

[24]  R. Hayashi,et al.  Systemic and pulmonary blood pressure during caesarean section in parturients with gestational hypertension , 1980, Canadian Anaesthetists' Society journal.