Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance.
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[1] N. Fujii,et al. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle , 2010, Proceedings of the National Academy of Sciences.
[2] B. Viollet,et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.
[3] K. Petersen,et al. Lipid-induced insulin resistance: unravelling the mechanism , 2010, The Lancet.
[4] R. Salgia,et al. Fyn: a novel molecular target in cancer. , 2010, Cancer.
[5] P. Aschner. Metabolic syndrome as a risk factor for diabetes , 2010, Expert review of cardiovascular therapy.
[6] J. Pessin,et al. Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. , 2010, Cell metabolism.
[7] A. Hevener,et al. AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance* , 2009, The Journal of Biological Chemistry.
[8] B. Kemp,et al. AMPK in Health and Disease. , 2009, Physiological reviews.
[9] F. Wondisford,et al. Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein , 2009, Cell.
[10] M. Zou,et al. Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis , 2009, Molecular and Cellular Biology.
[11] J. Zierath,et al. Hunting for the SNARK in metabolic disease. , 2009, American journal of physiology. Endocrinology and metabolism.
[12] Stefano Caserta,et al. T‐cell receptor proximal signaling via the Src‐family kinases, Lck and Fyn, influences T‐cell activation, differentiation, and tolerance , 2009, Immunological reviews.
[13] D. Hardie,et al. C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest* , 2009, Journal of Biological Chemistry.
[14] N. Ruderman,et al. SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1 , 2008, Journal of Biological Chemistry.
[15] D. Hardie,et al. AMPK: a key regulator of energy balance in the single cell and the whole organism , 2008, International Journal of Obesity.
[16] I. Bahar,et al. Structure and dynamic regulation of Src-family kinases , 2008, Cellular and Molecular Life Sciences.
[17] T. Ochiya,et al. Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci , 2008, Cancer science.
[18] H. Christofk,et al. Pyruvate kinase M2 is a phosphotyrosine-binding protein , 2008, Nature.
[19] G. Rutter,et al. Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8+ T-Cell–Induced Cytotoxicity , 2008, Diabetes.
[20] U. Stochaj,et al. Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway. , 2007, American journal of physiology. Cell physiology.
[21] G. Barsh,et al. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. , 2007, The Journal of clinical investigation.
[22] J. Pessin,et al. Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. , 2007, Cell metabolism.
[23] P. Schjerling,et al. Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction. , 2007, American journal of physiology. Endocrinology and metabolism.
[24] S. Okamoto,et al. Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase , 2007, Molecular and Cellular Biology.
[25] M. Birnbaum,et al. The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells* , 2007, Journal of Biological Chemistry.
[26] F. Pralong,et al. Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons. , 2007, Endocrinology.
[27] S. Yusuf,et al. The DREAM trial – Authors' reply , 2006, The Lancet.
[28] Michael D. Schneider,et al. A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway , 2006, Proceedings of the National Academy of Sciences.
[29] G. Rutter,et al. Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity , 2006, Diabetologia.
[30] Uwe Riek,et al. Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase* , 2006, Journal of Biological Chemistry.
[31] M. Laakso,et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial , 2006, The Lancet.
[32] M. Carlson,et al. Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro* , 2006, Journal of Biological Chemistry.
[33] Y. Uchijima,et al. Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression. , 2006, Diabetes research and clinical practice.
[34] B. Kahn,et al. Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle* , 2006, Journal of Biological Chemistry.
[35] D. Hardie,et al. AMP‐activated protein kinase – development of the energy sensor concept , 2006, The Journal of physiology.
[36] Kei Sakamoto,et al. LKB1-dependent signaling pathways. , 2006, Annual review of biochemistry.
[37] N. Musi. AMP-activated protein kinase and type 2 diabetes. , 2006, Current medicinal chemistry.
[38] Min-Seon Kim,et al. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. , 2006, Biochemical and biophysical research communications.
[39] R. DePinho,et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.
[40] N. Fujii,et al. AMP-activated Protein Kinase α2 Activity Is Not Essential for Contraction- and Hyperosmolarity-induced Glucose Transport in Skeletal Muscle* , 2005, Journal of Biological Chemistry.
[41] Xin-Yun Huang,et al. Requirement of SRC-family tyrosine kinases in fat accumulation. , 2005, Biochemistry.
[42] M. Prentki,et al. AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. , 2005, American journal of physiology. Endocrinology and metabolism.
[43] M. Goodarzi,et al. Metformin revisited: re‐evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents , 2005, Diabetes, obesity & metabolism.
[44] M. Montminy,et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.
[45] A. Means,et al. The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases* , 2005, Journal of Biological Chemistry.
[46] D. Hardie,et al. Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase* , 2005, Journal of Biological Chemistry.
[47] A. Edelman,et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. , 2005, Cell metabolism.
[48] Kei Sakamoto,et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction , 2005, The EMBO journal.
[49] B. Viollet,et al. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. , 2005, Diabetes.
[50] A. Saltiel,et al. The Stomatin/Prohibitin/Flotillin/HflK/C Domain of Flotillin-1 Contains Distinct Sequences That Direct Plasma Membrane Localization and Protein Interactions in 3T3-L1 Adipocytes* , 2005, Journal of Biological Chemistry.
[51] N. Fujii,et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. , 2005, Diabetes.
[52] Laura Conner,et al. Biochemical Regulation of Mammalian AMP-activated Protein Kinase Activity by NAD and NADH* , 2004, Journal of Biological Chemistry.
[53] D. Hardie. The AMP-activated protein kinase pathway – new players upstream and downstream , 2004, Journal of Cell Science.
[54] Arthur Weiss,et al. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation , 2004, Oncogene.
[55] B. Viollet,et al. Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit. , 2004, Diabetes.
[56] D. Hardie,et al. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. , 2004, American journal of physiology. Endocrinology and metabolism.
[57] M. Birnbaum,et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus , 2004, Nature.
[58] D. Carling,et al. AMP-activated Protein Kinase Plays a Role in the Control of Food Intake* , 2004, Journal of Biological Chemistry.
[59] Lewis C Cantley,et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[60] Peter Schjerling,et al. Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle* , 2004, Journal of Biological Chemistry.
[61] B. Kemp. Faculty Opinions recommendation of Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. , 2003 .
[62] Jérôme Boudeau,et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade , 2003, Journal of biology.
[63] M. Prentki,et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. , 2003, Endocrinology.
[64] M. Prentki,et al. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. , 2003, Acta physiologica Scandinavica.
[65] H C Clevers,et al. Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD , 2003, The EMBO journal.
[66] G. Rutter,et al. Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. , 2003, The Biochemical journal.
[67] D. Pipeleers,et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. , 2003, Journal of molecular endocrinology.
[68] J. W. Rush,et al. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. , 2003, American journal of physiology. Endocrinology and metabolism.
[69] D. Pipeleers,et al. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase , 2003, Diabetologia.
[70] H. Lodish,et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[71] T. Atkinson,et al. Identification of an alternatively spliced isoform of the fyn tyrosine kinase. , 2002, Biochemical and biophysical research communications.
[72] David Carling,et al. The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways* , 2002, The Journal of Biological Chemistry.
[73] Olle Ljunqvist,et al. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. , 2002, Diabetes.
[74] D. Olive,et al. Cutting Edge: Recruitment of the Ancestral fyn Gene During Emergence of the Adaptive Immune System1 , 2002, Journal of Immunology.
[75] Young-Bum Kim,et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature.
[76] Y. Terauchi,et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.
[77] G. Sapkota,et al. Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth* , 2001, The Journal of Biological Chemistry.
[78] M. Bucan,et al. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. , 2001, Molecular cell.
[79] P. Stein,et al. A Unique Role for Fyn in CNS Myelination , 2001, The Journal of Neuroscience.
[80] B. Kemp,et al. Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. , 2001, The Biochemical journal.
[81] D. Carling,et al. Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase , 2000, Molecular and Cellular Biology.
[82] D. Hardie,et al. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. , 2000, Diabetes.
[83] D. Carling,et al. The regulation of AMP-activated protein kinase by phosphorylation. , 2000, The Biochemical journal.
[84] M. Uhler,et al. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. , 2000, The Biochemical journal.
[85] B. Kemp,et al. Expression of the AMP‐activated protein kinase β1 and β2 subunits in skeletal muscle , 1999 .
[86] L. Goodyear,et al. 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. , 1999, Diabetes.
[87] G. Shulman,et al. Effect of AMPK activation on muscle glucose metabolism in conscious rats. , 1999, American journal of physiology. Endocrinology and metabolism.
[88] M. Yanagisawa,et al. ETB receptor activation leads to activation and phosphorylation of NHE3. , 1999, American journal of physiology. Cell physiology.
[89] B. Kemp,et al. Cellular Distribution and Developmental Expression of AMP‐Activated Protein Kinase Isoforms in Mouse Central Nervous System , 1999, Journal of neurochemistry.
[90] S. Anderson,et al. Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase* , 1999, The Journal of Biological Chemistry.
[91] Y. Minokoshi,et al. Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats , 1998, Neuroscience Research.
[92] A. Edelman,et al. Components of a Calmodulin-dependent Protein Kinase Cascade , 1998, The Journal of Biological Chemistry.
[93] D. Hardie,et al. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. , 1998, The Biochemical journal.
[94] A. Prescott,et al. AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. , 1998, The Biochemical journal.
[95] I. Leclerc,et al. The 5′‐AMP‐activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex , 1998, FEBS letters.
[96] D. Carling,et al. AMP-activated Protein Kinase Inhibits the Glucose-activated Expression of Fatty Acid Synthase Gene in Rat Hepatocytes* , 1998, The Journal of Biological Chemistry.
[97] C. Thornton,et al. Identification of a Novel AMP-activated Protein Kinase β Subunit Isoform That Is Highly Expressed in Skeletal Muscle* , 1998, The Journal of Biological Chemistry.
[98] D. Hardie,et al. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. , 1997, American journal of physiology. Endocrinology and metabolism.
[99] R. Burcelin,et al. Acute stimulation of glucose metabolism in mice by leptin treatment , 1997, Nature.
[100] A. Saltiel,et al. Insulin-stimulated Tyrosine Phosphorylation of Caveolin Is Specific for the Differentiated Adipocyte Phenotype in 3T3-L1 Cells* , 1997, The Journal of Biological Chemistry.
[101] J. McGarry,et al. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. , 1997, European journal of biochemistry.
[102] J. C. Parrish,et al. Synergy in Protein Engineering , 1996, The Journal of Biological Chemistry.
[103] M. White,et al. The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation (*) , 1996, The Journal of Biological Chemistry.
[104] J. Scott,et al. Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. , 1996, The Journal of biological chemistry.
[105] B. Kemp,et al. Mammalian AMP-activated Protein Kinase Subfamily (*) , 1996, The Journal of Biological Chemistry.
[106] D. Hardie,et al. The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle , 1995 .
[107] J. Scott,et al. The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. , 1995, European journal of biochemistry.
[108] B. Kemp,et al. Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase. , 1994, The Journal of biological chemistry.
[109] P. Brickell,et al. src‐related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells , 1994, FEBS letters.
[110] J. Scott,et al. Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. , 1994, The Journal of biological chemistry.
[111] M. Resh,et al. Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization. , 1994, The Journal of biological chemistry.
[112] B. Sefton,et al. Role of tyrosine kinases in lymphocyte activation. , 1994, Current opinion in immunology.
[113] K. Semba,et al. Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system. , 1993, The Journal of biological chemistry.
[114] L. Witters,et al. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. , 1993, The Journal of biological chemistry.
[115] H. Greulich,et al. A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues. , 1993, Oncogene.
[116] Cook Mp,et al. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. , 1989 .
[117] G. Cook,et al. Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA. , 1987, The Journal of biological chemistry.
[118] R. Pratley,et al. Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes. , 2009, The Journal of clinical endocrinology and metabolism.
[119] Louise Lantier,et al. AMPK: Lessons from transgenic and knockout animals. , 2009, Frontiers in bioscience.
[120] M. Kirby,et al. Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. , 2009, Clinical science.
[121] C. Polge,et al. SNF1/AMPK/SnRK1 kinases, global regulators at the heart of energy control? , 2007, Trends in plant science.
[122] D. Pipeleers,et al. Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. , 2007, Free radical biology & medicine.
[123] M. Birnbaum,et al. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. , 2007, The Journal of biological chemistry.
[124] Roy J Martin,et al. Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. , 2005, Endocrinology.
[125] B. Viollet,et al. Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. , 2004, The Journal of biological chemistry.
[126] B. Viollet,et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. , 2003, The Journal of clinical investigation.
[127] B. Kemp,et al. Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle. , 1999, FEBS letters.
[128] J. Nezu,et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. , 1998, Nature genetics.
[129] Darryl Shibata,et al. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis , 1997, Nature Genetics.
[130] R. Perlmutter,et al. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. , 1989, The New biologist.