Preview : Published ahead of advance online publication Controversies in the identification and management of acute pulmonary hypertension in preterm neonates

This is a PDF file of an unedited peer-reviewed manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

[1]  Shori Takahashi,et al.  Retinopathy of prematurity after sildenafil treatment , 2017, Pediatrics international : official journal of the Japan Pediatric Society.

[2]  F. D’Ascenzi,et al.  TAPSE: An old but useful tool in different diseases. , 2016, International journal of cardiology.

[3]  Hsiang-Yu Lin,et al.  Circulatory Management Focusing on Preventing Intraventricular Hemorrhage and Pulmonary Hemorrhage in Preterm Infants. , 2016, Pediatrics and neonatology.

[4]  C. Jayadev,et al.  Possible Role of Sildenafil Citrate in the Recurrence of Neovascularization in Laser-regressed Aggressive Posterior ROP. , 2016, Indian pediatrics.

[5]  Praveen K. Chandrasekharan,et al.  Early Use of Inhaled Nitric Oxide in Preterm Infants: Is there a Rationale for Selective Approach? , 2016, American Journal of Perinatology.

[6]  E. Aleo,et al.  Oral sildenafil for severe pulmonary hypertension developing after ibuprofen use in a neonate , 2016, Indian Pediatrics.

[7]  S. Maskatia,et al.  Longitudinal Changes and Interobserver Variability of Systolic Myocardial Deformation Values in a Prospective Cohort of Healthy Fetuses across Gestation and after Delivery. , 2016, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[8]  W. Chung,et al.  Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society , 2015, Circulation.

[9]  P. Smith,et al.  Right ventricular echocardiographic indices predict poor outcomes in infants with persistent pulmonary hypertension of the newborn. , 2015, European heart journal cardiovascular Imaging.

[10]  K. Thornburg,et al.  Timing of cardiomyocyte growth, maturation, and attrition in perinatal sheep , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  M. Laughon,et al.  Sildenafil and Retinopathy of Prematurity Risk in Very Low Birth Weight Infants , 2015, Journal of Perinatology.

[12]  C. Romagnoli,et al.  Determination of Lung Volume and Hemodynamic Changes During High-Frequency Ventilation Recruitment in Preterm Neonates With Respiratory Distress Syndrome , 2015, Critical care medicine.

[13]  I. Seri,et al.  Hemodynamic antecedents of peri/intraventricular hemorrhage in very preterm neonates. , 2015, Seminars in fetal & neonatal medicine.

[14]  H. Balasubramanian,et al.  Arterial hypotension and prerenal failure in an extremely preterm infant associated with oral sildenafil , 2015, Journal of Perinatology.

[15]  J. Kaiser,et al.  Vasopressin versus dopamine for treatment of hypotension in extremely low birth weight infants: a randomized, blinded pilot study. , 2015, The Journal of pediatrics.

[16]  S. O'Donnell,et al.  Inhaled nitric oxide in preterm infants with prolonged preterm rupture of the membranes: a case series , 2015, Journal of Perinatology.

[17]  P. McNamara,et al.  A comprehensive echocardiographic protocol for assessing neonatal right ventricular dimensions and function in the transitional period: normative data and z scores. , 2014, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[18]  P. McNamara,et al.  Assessment of myocardial performance in preterm infants less than 29 weeks gestation during the transitional period. , 2014, Early human development.

[19]  P. McNamara,et al.  Treatment of premature infants with pulmonary hypertension and right ventricular dysfunction with milrinone: a case series , 2014, Journal of Perinatology.

[20]  S. Berkelhamer,et al.  Developmental regulation of antioxidant enzymes and their impact on neonatal lung disease. , 2014, Antioxidants & redox signaling.

[21]  Xinnian Pan,et al.  [Efficacy of inhaled nitric oxide in premature infants with hypoxic respiratory failure]. , 2014, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.

[22]  A. Berger,et al.  Intravenous Sildenafil i. v. as Rescue Treatment for Refractory Pulmonary Hypertension in Extremely Preterm Infants , 2014, Klinische Pädiatrie.

[23]  S. Donn,et al.  Sildenafil for pulmonary hypertension complicating bronchopulmonary dysplasia , 2014, Expert review of clinical pharmacology.

[24]  A. Redington,et al.  Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. , 2014, American journal of physiology. Heart and circulatory physiology.

[25]  A. Fawzi,et al.  Sildenafil attenuates vaso-obliteration and neovascularization in a mouse model of retinopathy of prematurity. , 2014, Investigative ophthalmology & visual science.

[26]  F. Martinez,et al.  Pulmonary hypertension due to left heart diseases. , 2013, Journal of the American College of Cardiology.

[27]  J. Hajnal,et al.  Validation Study of the Accuracy of Echocardiographic Measurements of Systemic Blood Flow Volume in Newborn Infants , 2013, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[28]  Francesc Carreras,et al.  Helical structure of the cardiac ventricular anatomy assessed by diffusion tensor magnetic resonance imaging with multiresolution tractography. , 2013, Revista espanola de cardiologia.

[29]  O. Kilic,et al.  Inhaled Iloprost in Preterm Infants with Severe Respiratory Distress Syndrome and Pulmonary Hypertension , 2013, American Journal of Perinatology.

[30]  M. Meyer,et al.  Oxygen saturation and outcomes in preterm infants. , 2013, The New England journal of medicine.

[31]  K. J. Guy,et al.  The effect of sildenafil on retinopathy of prematurity in very preterm infants , 2013, Journal of Perinatology.

[32]  P. McNamara,et al.  Persistent Pulmonary Hypertension of the Newborn: Physiology, Hemodynamic Assessment and Novel Therapies , 2013 .

[33]  P. McNamara,et al.  Pharmacology of Milrinone in Neonates With Persistent Pulmonary Hypertension of the Newborn and Suboptimal Response to Inhaled Nitric Oxide* , 2013, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[34]  G. Sant’Anna,et al.  Severe airway obstruction during surfactant administration using a standardized protocol: a prospective, observational study , 2012, Journal of Perinatology.

[35]  C. Romagnoli,et al.  Target fraction of inspired oxygen during open lung strategy in neonatal high frequency oscillatory ventilation: a retrospective study. , 2012, Minerva anestesiologica.

[36]  M. Kluckow,et al.  Noninvasive Assessment of the Early Transitional Circulation in Healthy Term Infants , 2011, Neonatology.

[37]  B. Gürakan,et al.  Therapeutic combination of sildenafil and iloprost in a preterm neonate with pulmonary hypertension , 2011, Pediatric pulmonology.

[38]  Rami Dhillon The management of neonatal pulmonary hypertension , 2011, Archives of Disease in Childhood: Fetal and Neonatal Edition.

[39]  S. Patole,et al.  Current and future therapeutic options for persistent pulmonary hypertension in the newborn , 2010, Expert review of cardiovascular therapy.

[40]  B. Poindexter,et al.  Target ranges of oxygen saturation in extremely preterm infants. , 2010, The New England journal of medicine.

[41]  V. Ahel,et al.  Preoperative management of hypoplastic left heart syndrome , 2009 .

[42]  H. Tamai,et al.  Low‐dose vasopressin infusion therapy for refractory hypotension in ELBW infants , 2009, Pediatrics international : official journal of the Japan Pediatric Society.

[43]  M. Gatzoulis,et al.  Updated clinical classification of pulmonary hypertension. , 2009, Journal of the American College of Cardiology.

[44]  J. H. van der Lee,et al.  Effect of lung recruitment on pulmonary, systemic, and ductal blood flow in preterm infants. , 2009, The Journal of pediatrics.

[45]  D. Swartz,et al.  Exposure to Supplemental Oxygen Downregulates Antioxidant Enzymes and Increases Pulmonary Arterial Contractility in Premature Lambs , 2009, Neonatology.

[46]  R. Lalonde,et al.  Population Pharmacokinetics of Sildenafil in Term Neonates: Evidence of Rapid Maturation of Metabolic Clearance in the Early Postnatal Period , 2009, Clinical pharmacology and therapeutics.

[47]  R. Ehrenkranz,et al.  Inhaled Nitric Oxide for Preterm Premature Rupture of Membranes, Oligohydramnios, and Pulmonary Hypoplasia , 2008, American journal of perinatology.

[48]  P. Tourneux,et al.  Pulmonary circulatory effects of norepinephrine in newborn infants with persistent pulmonary hypertension. , 2008, The Journal of pediatrics.

[49]  James D. Thomas,et al.  Evaluation of myocardial mechanics in the fetus by velocity vector imaging. , 2008, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[50]  P. Su,et al.  Inhaled nitric oxide in the management of preterm infants with severe respiratory failure , 2008, Journal of Perinatology.

[51]  R. Hines,et al.  Ontogeny of human hepatic cytochromes P450 , 2007, Journal of biochemical and molecular toxicology.

[52]  K. Barrington,et al.  Cochrane review: Nitric oxide for respiratory failure in infants born at or near term , 2007 .

[53]  S. Lakshminrusimha,et al.  Characteristics of pulmonary hypertension in preterm neonates , 2007, Journal of Perinatology.

[54]  A. Peco‐Antić,et al.  Blood pressure in non-critically ill preterm and full-term neonates , 2007, Pediatric Nephrology.

[55]  A. V. van Kaam,et al.  Lung recruitment using oxygenation during open lung high-frequency ventilation in preterm infants. , 2006, American journal of respiratory and critical care medicine.

[56]  L. Filippi,et al.  Inhaled nitric oxide in very preterm infants with severe respiratory distress syndrome , 2006, Acta paediatrica.

[57]  Nico Westerhof,et al.  Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension. , 2006, American journal of physiology. Heart and circulatory physiology.

[58]  A. McLachlan,et al.  Pilot study of milrinone for low systemic blood flow in very preterm infants. , 2006, The Journal of pediatrics.

[59]  W. Poole,et al.  Inhaled nitric oxide for premature infants with severe respiratory failure. , 2005, The New England journal of medicine.

[60]  A. Tanswell,et al.  Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat. , 2004, Free radical biology & medicine.

[61]  H. Tada,et al.  Nitric oxide inhalation therapy in very low‐birthweight infants with hypoplastic lung due to oligohydramnios , 2004, Pediatrics international : official journal of the Japan Pediatric Society.

[62]  Desandes R,et al.  Inhaled nitric oxide improves oxygenation in very premature infants with low pulmonary blood flow , 2004, Acta paediatrica.

[63]  E. Frohlich,et al.  Echocardiographic measurement of cardiac output in rats. , 2003, American journal of physiology. Heart and circulatory physiology.

[64]  P. Schaller,et al.  Functional residual capacity and compliance of the respiratory system after surfactant treatment in premature infants with severe respiratory distress syndrome , 2002, European Journal of Pediatrics.

[65]  M. Kluckow,et al.  Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow. , 2002, The Journal of pediatrics.

[66]  K. Walley,et al.  Physiology of vasopressin relevant to management of septic shock. , 2001, Chest.

[67]  F. Coceani,et al.  Contractile and Relaxing Mechanisms in Pulmonary Resistance Arteries of the Preterm Fetal Lamb , 2000, Neonatology.

[68]  R. Pearl,et al.  Additive effects of inhaled nitric oxide and intravenous milrinone in experimental pulmonary hypertension , 2000, Critical care medicine.

[69]  D. Cornfield,et al.  Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial , 1999, The Lancet.

[70]  U. Thome,et al.  Comparison of lung volume measurements by antero‐posterior chest X‐ray and the SF6 washout technique in mechanically ventilated infants , 1998, Pediatric pulmonology.

[71]  L. McCloud,et al.  Ventilation above closing volume reduces pulmonary vascular resistance hysteresis. , 1998, American journal of respiratory and critical care medicine.

[72]  J. Anker,et al.  Endotracheal instillation of prostacyclin in preterm infants with persistent pulmonary hypertension. , 1998, The European respiratory journal.

[73]  M. D'Alton,et al.  Cardiac Dysfunction in Twin–Twin Transfusion Syndrome: A Prospective, Longitudinal Study , 1998, Obstetrics and gynecology.

[74]  K. Harada,et al.  Maturational changes in left ventricular contractile state. , 1998, International journal of cardiology.

[75]  V. Soditt,et al.  Improvement of oxygenation induced by aerosolized prostacyclin in a preterm infant with persistent pulmonary hypertension of the newborn , 1997, Intensive Care Medicine.

[76]  G. Dimitriou,et al.  Early measurement of lung volume--a useful discriminator of neonatal respiratory failure severity. , 1996, Physiological measurement.

[77]  K. Barrington,et al.  A blind, randomized comparison of the circulatory effects of dopamine and epinephrine infusions in the newborn piglet during normoxia and hypoxia. , 1995, Critical care medicine.

[78]  U. Dyamenahalli,et al.  Adrenoceptor-stimulated endothelium-dependent relaxation in porcine intrapulmonary arteries. , 1994, Pulmonary pharmacology.

[79]  P. Shaul,et al.  Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression. , 1994, The Journal of clinical investigation.

[80]  M. Yanagisawa,et al.  Left ventricular contractile state in preterm infants: relation between wall stress and velocity of circumferential fiber shortening. , 1994, American heart journal.

[81]  R. Wilkening,et al.  Inhaled nitric oxide in the management of a premature newborn with severe respiratory distress and pulmonary hypertension. , 1993, Pediatrics.

[82]  S. Glantz,et al.  Mechanically Increased Right Ventricular Afterload Alters Left Ventricular Configuration, Not Contractility, in Neonatal Lambs , 1993, Pediatric Research.

[83]  P. Russo,et al.  Pressure-volume relationship of the fetal lamb heart. , 1993, The Annals of thoracic surgery.

[84]  A. Bryan,et al.  Relationship between PaO2 and Lung Volume during High Frequency Oscillatory Ventilation , 1992, Acta paediatrica Japonica : Overseas edition.

[85]  K. Thornburg,et al.  Severe Right Ventricular Pressure Loading in Fetal Sheep Augments Global Myocardial Blood Flow to Submaximal Levels , 1992, Circulation.

[86]  E. Egan,et al.  Pulmonary hemodynamics in fetal lambs during development at normal and increased oxygen tension. , 1992, Journal of applied physiology.

[87]  M. Mathru,et al.  Norepinephrine and phenylephrine effects on right ventricular function in experimental canine pulmonary embolism. , 1991, Chest.

[88]  L. Frank,et al.  Failure of Premature Rabbits to Increase Antioxidant Enzymes During Hyperoxic Exposure: Increased Susceptibility to Pulmonary Oxygen Toxicity Compared with Term Rabbits , 1991, Pediatric Research.

[89]  H. Whyte,et al.  Doppler echocardiographic measurement of pulmonary artery pressure from ductal Doppler velocities in the newborn. , 1990, Journal of the American College of Cardiology.

[90]  R. Ruffolo ReviewReview: The Pharmacology of Dobutamine , 1987 .

[91]  M. Cutaia,et al.  Hypoxia-induced alterations of norepinephrine vascular reactivity in isolated perfused cat lung. , 1987, Journal of applied physiology.

[92]  T. Nakanishi,et al.  Effect of Milrinone on Myocardial Mechanical Function and Cyclic AMP Content in the Fetal Rabbit , 1987, Pediatric Research.

[93]  K. Reed,et al.  Doppler echocardiographic studies of diastolic function in the human fetal heart: changes during gestation. , 1986, Journal of the American College of Cardiology.

[94]  D. Brutsaert,et al.  Inotropic effects of amrinone and milrinone on contraction and relaxation of isolated cardiac muscle. , 1986, Circulation.

[95]  A. Timmis,et al.  Milrinone in heart failure. Acute effects on left ventricular systolic function and myocardial metabolism. , 1985, British heart journal.

[96]  M. J. Conley,et al.  An echocardiographic index for separation of right ventricular volume and pressure overload. , 1985, Journal of the American College of Cardiology.

[97]  E. Donovan,et al.  Influence of airway pressure waveform on cardiac output during positive pressure ventilation of healthy newborn dogs. , 1985, Pediatric research.

[98]  M. G. St. John Sutton,et al.  Left ventricular function in persistent pulmonary hypertension of the newborn. Computer analysis of the echocardiogram. , 1983, British heart journal.

[99]  K. Thornburg,et al.  Filling and arterial pressures as determinants of RV stroke volume in the sheep fetus. , 1983, The American journal of physiology.

[100]  J. Buecker,et al.  Development of Dyadic Junctional Complexes between Sarcoplasmic Reticulum and Plasmalemma in Rabbit Left Ventricular Myocardial Cells: Morphometric Analysis , 1981, Circulation research.

[101]  W. Friedman,et al.  Limited Left Ventricular Response to Volume Overload in the Neonatal Period: a Comparative Study with the Adult Animal , 1979, Pediatric Research.

[102]  C. Leffler,et al.  Pulmonary and systemic vascular responses of perinatal goats to prostaglandins E1 and E2. , 1979, The American journal of physiology.

[103]  M. Heymann,et al.  Gestational Changes in Pulmonary Vascular Responses in Fetal Lambs in Utero , 1976, Circulation research.

[104]  R. Roberts,et al.  Developmental Characteristics of Pulmonary Superoxide Dismutase: Relationship to Idiopathic Respiratory Distress Syndrome , 1976, Pediatric Research.

[105]  W. Friedman,et al.  The intrinsic physiologic properties of the developing heart. , 1972, Progress in cardiovascular diseases.

[106]  M. Heymann,et al.  Circulatory Changes during Growth in the Fetal Lamb , 1970, Circulation research.

[107]  A. Hauge Hypoxia and pulmonary vascular resistance. The relative effects of pulmonary arterial and alveolar PO2. , 1969, Acta physiologica Scandinavica.

[108]  A. Rudolph,et al.  Response of the pulmonary vasculature to hypoxia and H+ ion concentration changes. , 1966, The Journal of clinical investigation.

[109]  P. Auld,et al.  Pulmonary vascular adjustments in the neonatal period. , 1961, Pediatrics.

[110]  J. Whittenberger,et al.  Influence of state of inflation of the lung on pulmonary vascular resistance. , 1960, Journal of applied physiology.

[111]  R. Dellaca’,et al.  Relationship between Mean Airways Pressure, Lung Mechanics, and Right Ventricular Output during High‐Frequency Oscillatory Ventilation in Infants , 2017, The Journal of pediatrics.

[112]  L. Badano,et al.  Right ventricle in pulmonary arterial hypertension: haemodynamics, structural changes, imaging, and proposal of a study protocol aimed to assess remodelling and treatment effects. , 2010, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[113]  D. Vidyasagar,et al.  Retrospective diagnosis of hypoxic myocardial injury in premature newborns , 2006, Journal of perinatal medicine.

[114]  Gordon L. Shaw Clinical implications , 2004, European Journal of Pediatrics.

[115]  K. Barrington,et al.  Inhaled nitric oxide for respiratory failure in preterm infants. , 2001, The Cochrane database of systematic reviews.

[116]  Xiao-ling Guo,et al.  Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[117]  K. Barrington,et al.  Systemic, pulmonary and mesenteric perfusion and oxygenation effects of dopamine and epinephrine. , 1997, American journal of respiratory and critical care medicine.

[118]  V. Demarco,et al.  The Effects of Nitric Oxide Inhalation on the Pulmonary Circulation of Preterm Lambs , 1995, Pediatric Research.

[119]  F. Kelly,et al.  Magnitude of hyperoxic stress and degree of lung maturity determine the nature of pulmonary antioxidant response in the guinea pig. , 1992, Free radical research communications.

[120]  D. Warburton,et al.  Ontogeny of antioxidant enzymes in the fetal lamb lung. , 1991, Experimental lung research.

[121]  L. Frank,et al.  Prenatal development of lung antioxidant enzymes in four species. , 1987, The Journal of pediatrics.

[122]  J. Spadaro,et al.  Effects of dopamine on the pulmonary circulation of the dog. , 1984, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.