A new cold autoagglutinin specificity: the third external loop of band 3

BACKGROUND: Cold autoagglutinins (CAs) are almost always of immunoglobulin (Ig)M class and specific for carbohydrate antigens. We report a case of hemolytic anemia caused by a mixture of IgM and IgG cold agglutinins. Both agglutinins were specific for the third extracellular loop of band 3.

[1]  R. Thorpe,et al.  Anti-D and anti-i activities are inseparable in V4-34-encoded monoclonal anti-D: the same framework 1 residues are required for both reactivities. , 2008, Transfusion.

[2]  P. Rohrlich,et al.  Severe autoimmune hemolytic anemia caused by a warm IgA autoantibody directed against the third loop of band 3 (RBC anion‐exchange protein 1) , 2002, Transfusion.

[3]  T. Omi,et al.  Reactivity of autoantibodies of autoimmune hemolytic anemia with recombinant rhesus blood group antigens or anion transporter band3 , 2001, American journal of hematology.

[4]  R. Rudigoz,et al.  Severe hereditary spherocytosis and distal renal tubular acidosis associated with the total absence of band 3. , 2000, Blood.

[5]  Elson,et al.  Splenic but not thymic autoreactive T cells from New Zealand Black mice respond to a dominant erythrocyte Band 3 peptide , 1999, Immunology.

[6]  M. Benbunan,et al.  New Murine Monoclonal Antibodies Directed against Glycophorins C and D, Have Anti‐Ge2 Specificity , 1998, Vox Sanguinis.

[7]  H. Gross,et al.  α2,3-Specific Desialylation of Human Red Cells: Effect on the Autoantigens of the Pr, Sa and Sia-l1, -b1, -lb1 Series , 1998, Vox Sanguinis.

[8]  Turner,et al.  Human monoclonal antibodies encoded by the V4‐34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy‐chain variable region , 1998, Immunology.

[9]  M. Tanner,et al.  The structure and function of band 3 (AE1): recent developments (review). , 1997, Molecular membrane biology.

[10]  G. Garratty,et al.  Severe Autoimmune Hemolytic Anemia Associated with IgM Warm Autoantibodies Directed against Determinants on or Associated with Glycophorin A , 1997, Vox sanguinis.

[11]  P. Issitt,et al.  Anti‐Dib as a red cell autoantibody , 1996, Transfusion.

[12]  D. Anstee,et al.  Monoclonal antibodies recognizing epitopes on the extracellular face and intracellular N-terminus of the human erythrocyte anion transporter (band 3) and their application to the analysis of South East Asian ovalocytes. , 1995, Blood.

[13]  M. Reid,et al.  Changes in the blood group Wright antigens are associated with a mutation at amino acid 658 in human erythrocyte band 3: a site of interaction between band 3 and glycophorin A under certain conditions [see comments] , 1995 .

[14]  M. Tanner,et al.  Changes in the blood group Wright antigens are associated with a mutation at amino acid 658 in human erythrocyte band 3: a site of interaction between band 3 and glycophorin A under certain conditions. , 1995, Blood.

[15]  M. King,et al.  An assessment of the immunoprecipitation of blood-group antigens using biotinylated red cells. , 1994, Transfusion Medicine.

[16]  F. Stevenson,et al.  Anti‐j: Human Cold Agglutinins Recognizing Linear (i) and Branched (I) Type 2 Chains , 1994, Vox sanguinis.

[17]  P. Lydyard,et al.  Pathogenic autoantibodies in the NZB mouse are specific for erythrocyte Band 3 protein , 1993, European journal of immunology.

[18]  P. Issitt.  Null red blood cell phenotypes: associated biological changes. , 1993, Transfusion medicine reviews.

[19]  Sherry,et al.  Erythrocyte membrane proteins reactive with human (warm-reacting) anti-red cell autoantibodies. , 1993, The Journal of clinical investigation.

[20]  M. Tanner,et al.  A red cell band 3 variant with altered stilbene disulphonate binding is associated with the Diego (Dia) blood group antigen. , 1992, The Biochemical journal.

[21]  G. Daniels.  Effect of enzymes on and chemical modifications of high-frequency red cell antigens , 1992, Immunohematology.

[22]  D. Roelcke.  Cold agglutination. , 1989, Transfusion medicine reviews.

[23]  M. Tanner,et al.  The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence. , 1988, The Biochemical journal.

[24]  D. Roelcke,et al.  Cold Agglutinin Vo: An IgMλ Monoclonal Human Antibody Recognizing a Sialic Acid Determined Antigen Fully Expressed on Newborn Erythrocytes 1 , 1984, Vox sanguinis.

[25]  D. Roelcke.  A Further Cold Agglutinin, Fl, Recognizing a N‐Acetylneuraminic Acid‐Determined Antigen , 1981, Vox sanguinis.

[26]  S. Hakomori,et al.  Developmental change and genetic defect in the carbohydrate structure of band 3 glycoprotein of human erythrocyte membrane. , 1979, The Journal of biological chemistry.

[27]  D. Roelcke,et al.  Serological Identification of the New Cold Agglutinin Specificity Anti‐Gd , 1977, Vox sanguinis.

[28]  D. Goldfinger,et al.  Anti‐Wrb, and Other Autoantibodies Responsible for Positive Direct Antiglobulin Tests in 150 Individuals , 1976, British journal of haematology.

[29]  W. Rosse,et al.  Immune hemolytic anemias. , 1971, Modern treatment.

[30]  H. Fudenberg,et al.  Specificity of Acquired Haemolytic Anaemia Autoantibodies and their Scrological Characteristics , 1970, British journal of haematology.

[31]  W. Marsh,et al.  Anti‐Sp1: The Recognition of a New Cold Auto‐Antibody , 1968, Vox sanguinis.

[32]  P. Booth,et al.  Anti‐IT: A New Antibody of the I Blood‐Group System Occurring in Certain Melanesian Sera , 1966, British journal of haematology.

[33]  S. Worlledge,et al.  Studies on the Serology of Paroxysmal Cold Haemoglobinuria (P.C.H.), with Special Reference to its Relationship with the P Blood Group System , 1965, Vox sanguinis.

[34]  W. Weiner,et al.  SEROLOGY OF ACQUIRED HEMOLYTIC ANEMIAS. , 1963, Blood.

[35]  J. Dreyfus,et al.  Ageing of Hæmoglobin , 1960, Nature.

[36]  W. Marsh,et al.  Anti-i : a New Cold Antibody , 1960, Nature.

[37]  A. S. Wiener,et al.  Type-specific cold auto-antibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions: biologic test with bovine red cells. , 1956, Annals of internal medicine.

[38]  F. Stratton,et al.  Human Blood Groups , 1951, Nature.