Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

[1]  E. Boccardo,et al.  Metabolic Reprogramming and Cancer , 2021, Essential Aspects of Immunometabolism in Health and Disease.

[2]  C. Pilarsky,et al.  The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter , 2021, Oncogene.

[3]  I. Asangani,et al.  Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer , 2020, bioRxiv.

[4]  P. Ceppi,et al.  Targeting EMT in Cancer with Repurposed Metabolic Inhibitors. , 2020, Trends in cancer.

[5]  Daohong Zhou,et al.  PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics , 2020, Oncogene.

[6]  A. Azem,et al.  Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin , 2020, Nature Communications.

[7]  B. Faubert,et al.  Metabolic reprogramming and cancer progression , 2020, Science.

[8]  A. Pitruzzella,et al.  Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors? , 2020, Journal of oncology.

[9]  Hyung Joo Kim,et al.  Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy , 2019, Cells.

[10]  Y. Seo,et al.  Understanding of ROS-Inducing Strategy in Anticancer Therapy , 2019, Oxidative medicine and cellular longevity.

[11]  B. Faubert,et al.  Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer , 2019, Nature Communications.

[12]  P. Ma,et al.  Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy , 2019, Journal of Hematology & Oncology.

[13]  Xiuyun Sun,et al.  PROTACs: great opportunities for academia and industry , 2019, Signal Transduction and Targeted Therapy.

[14]  C. Garrido,et al.  Heat-shock proteins: chaperoning DNA repair , 2019, Oncogene.

[15]  R. Deberardinis,et al.  Mechanisms and Implications of Metabolic Heterogeneity in Cancer. , 2019, Cell metabolism.

[16]  Ligong Chen,et al.  Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses. , 2019, Immunity.

[17]  J. Molina,et al.  Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment. , 2019, Mayo Clinic proceedings.

[18]  Min Huang,et al.  Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer , 2019, Nature Communications.

[19]  Yuling Chen,et al.  HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells , 2019, Redox biology.

[20]  Erin L. Schenk,et al.  Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer , 2019, Front. Immunol..

[21]  G. G. Galli,et al.  The landscape of cancer cell line metabolism , 2019, Nature Medicine.

[22]  Emanuel J. V. Gonçalves,et al.  Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens , 2019, Nature.

[23]  I. Asangani,et al.  Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers , 2019, Cell Death & Differentiation.

[24]  A. Marino Gammazza,et al.  Hsp60 in Skeletal Muscle Fiber Biogenesis and Homeostasis: From Physical Exercise to Skeletal Muscle Pathology , 2018, Cells.

[25]  Eric A. Smith,et al.  Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer , 2018, Nature Metabolism.

[26]  A. Shonhai,et al.  Heat Shock Proteins as Immunomodulants , 2018, Molecules.

[27]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[28]  Edith M. Ross,et al.  KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice , 2018, Science Translational Medicine.

[29]  G. Kroemer,et al.  Metabolic vulnerability of cisplatin‐resistant cancers , 2018, The EMBO journal.

[30]  Hongwei Sun,et al.  Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth , 2018, Cell Death & Disease.

[31]  Roy S. Herbst,et al.  The biology and management of non-small cell lung cancer , 2018, Nature.

[32]  F. Askin,et al.  Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. , 2017, Seminars in cancer biology.

[33]  T. Burns,et al.  Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach , 2017, International journal of molecular sciences.

[34]  Jasleen Saini,et al.  Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer. , 2017, Current drug targets.

[35]  F. Sotgia,et al.  Mitochondrial markers predict survival and progression in non-small cell lung cancer (NSCLC) patients: Use as companion diagnostics , 2017, Oncotarget.

[36]  Antoine de Weck,et al.  Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening , 2017, Cell.

[37]  R. Visconti,et al.  The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy , 2017, International journal of molecular sciences.

[38]  Y. Sakai,et al.  Targeting metabolic reprogramming in KRAS-driven cancers , 2017, International Journal of Clinical Oncology.

[39]  P. Ceppi,et al.  Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial‐to‐mesenchymal transition of cancer cells , 2017, The Journal of pathology.

[40]  Jianpeng Ma,et al.  Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation. , 2017, Cancer research.

[41]  Qibing Mei,et al.  Heat Shock Proteins and Cancer. , 2017, Trends in pharmacological sciences.

[42]  Heribert Hirt,et al.  The heat‐shock protein/chaperone network and multiple stress resistance , 2017, Plant biotechnology journal.

[43]  S. Benkő,et al.  NLRC5 Functions beyond MHC I Regulation—What Do We Know So Far? , 2017, Front. Immunol..

[44]  K. Stegmaier,et al.  The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia , 2017, Nature Medicine.

[45]  Matthew G. Vander Heiden,et al.  Understanding the Intersections between Metabolism and Cancer Biology , 2017, Cell.

[46]  M. Heikenwalder,et al.  Mitochondrial function controls intestinal epithelial stemness and proliferation , 2016, Nature Communications.

[47]  R. Govindan,et al.  PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[48]  Jun S. Liu,et al.  MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens , 2014, Genome Biology.

[49]  Neville E. Sanjana,et al.  Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.

[50]  F. Davies,et al.  Heat shock proteins in multiple myeloma , 2014, Oncotarget.

[51]  Edward Y. Chen,et al.  Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool , 2013, BMC Bioinformatics.

[52]  Benjamin E. Gross,et al.  The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. , 2012, Cancer discovery.

[53]  Adam A. Margolin,et al.  The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.

[54]  Jianxing He,et al.  Heat shock protein‐60 expression was significantly correlated with the prognosis of lung adenocarcinoma , 2011, Journal of surgical oncology.

[55]  J. Ross,et al.  Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis , 2011, Cellular and Molecular Life Sciences.

[56]  P. Schultz,et al.  A small molecule accelerates neuronal differentiation in the adult rat , 2010, Proceedings of the National Academy of Sciences.

[57]  Kou-Juey Wu,et al.  Interaction between HSP60 and beta-catenin promotes metastasis. , 2009, Carcinogenesis.

[58]  G. Scagliotti,et al.  Updated clinical information on multitargeted antifolates in lung cancer. , 2009, Clinical lung cancer.

[59]  R. Snow,et al.  Creatine and the creatine transporter: A review , 2001, Molecular and Cellular Biochemistry.

[60]  P. Rocmans,et al.  Increased expression of high but not low molecular weight heat shock proteins in resectable lung carcinoma. , 2001, Lung cancer.

[61]  R. Pirker.  Chemotherapy remains a cornerstone in the treatment of nonsmall cell lung cancer. , 2019, Current Opinion in Oncology.