Prevalence of anxiety and depressive symptoms among patients with hypothyroidism

Context: The association between depression and thyroid function is well known. Both conditions express many similar symptoms, thus making the diagnosis and treatment difficult. Aims: To find the prevalence of anxiety and depressive symptoms among patients with hypothyroid. Settings and Design: Cross-sectional study. Materials and Methodology: A total of 100 patients diagnosed as hypothyroidism were evaluated using Hamilton depression rating scale (HDRS) and Hamilton scale for anxiety (HAM-A). Statistical Analysis Used: The data were analyzed using the SPSS for Windows version 17.0 software. The quantitative data were expressed in number and percentage. The results obtained were compared using the Chi-square test. Results: Females constituted 70% of the sample. A total of 60% reported some degree of depression based on HDRS (males – 56.63% and females – 64.29%) whereas about 63% out of the total patients screened showed some degree of anxiety (males –56.66% and females – 65.72%) based on HAM-A. The most common depressive symptom among the males was depressed mood (73.33%) and among females was gastrointestinal somatic symptoms (68.54%). The most common anxiety symptom among the males was depressed mood (70.0%) and among females was anxious mood (92.85%). Conclusions: Psychiatric symptoms/disorders are common in patients with thyroid dysfunction.

[1]  B. Okopień,et al.  Sexual function and depressive symptoms in young women with thyroid autoimmunity and subclinical hypothyroidism , 2016, Clinical endocrinology.

[2]  I. Benseñor,et al.  Subclinical thyroid dysfunction and psychiatric disorders: cross‐sectional results from the Brazilian Study of Adult Health (ELSA‐Brasil) , 2016, Clinical endocrinology.

[3]  Benjamin T. Brown,et al.  A biopsychosocial approach to primary hypothyroidism: treatment and harms data from a randomized controlled trial , 2015, Chiropractic & Manual Therapies.

[4]  D. Bauer,et al.  Subclinical Thyroid Dysfunction and Depressive Symptoms among the Elderly: A Prospective Cohort Study , 2015, Neuroendocrinology.

[5]  P. Bech,et al.  Is suppressed thyroid-stimulating hormone (TSH) associated with subclinical depression in the Danish General Suburban Population Study? , 2015, Nordic journal of psychiatry.

[6]  H. Völzke,et al.  Diagnosed thyroid disorders are associated with depression and anxiety , 2015, Social Psychiatry and Psychiatric Epidemiology.

[7]  A. Jula,et al.  The Relationship between Thyroid Function and Depressive Symptoms—the FIN-D2D Population-Based Study , 2015, Clinical medicine insights. Endocrinology and diabetes.

[8]  G. Fava,et al.  Mood and Anxiety Disorders as Early Manifestations of Medical Illness: A Systematic Review , 2014, Psychotherapy and Psychosomatics.

[9]  R. Joffe,et al.  The Significance of an Isolated Elevated TSH Level in a Depressed Patient: A Clinical Commentary , 2014, International journal of psychiatry in medicine.

[10]  L. Hegedüs,et al.  Increased psychiatric morbidity before and after the diagnosis of hypothyroidism: a nationwide register study. , 2014, Thyroid : official journal of the American Thyroid Association.

[11]  A. Carvalho,et al.  Augmentation strategies for treatment-resistant depression , 2009, Current opinion in psychiatry.

[12]  R. McIntyre,et al.  What Are the Implications of the STAR*D Trial for Primary Care? A Review and Synthesis. , 2008, Primary care companion to the Journal of clinical psychiatry.

[13]  P. Saha,et al.  Prevalence of hypothyroidism and importance of cholesterol estimation in patients suffering from major depressive disorder. , 2008, Journal of the Indian Medical Association.

[14]  J. Janowsky,et al.  Health status, mood, and cognition in experimentally induced subclinical hypothyroidism. , 2007, The Journal of clinical endocrinology and metabolism.

[15]  Jennifer D. Davis,et al.  Neuropsychiatric aspects of hypothyroidism and treatment reversibility. . , 2007, Minerva endocrinologica.

[16]  R. Philibert,et al.  Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults , 2006, Acta psychiatrica Scandinavica.

[17]  J. Cole.  Psychoneuroendocrinology: The Scientific Basis of Clinical Practice , 2005 .

[18]  A. Mykletun,et al.  The Association Between Anxiety, Depression, and Somatic Symptoms in a Large Population: The HUNT-II Study , 2004, Psychosomatic medicine.

[19]  M. Frye,et al.  Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors. , 2004, Journal of psychiatry & neuroscience : JPN.

[20]  Jennifer D. Davis,et al.  Neurobehavioral functioning in thyroid disorders. , 2003, Medicine and health, Rhode Island.

[21]  G. Redmond.  Hypothyroidism and women's health. , 2002, International journal of fertility and women's medicine.

[22]  B. Costall,et al.  Thyroid hormones, brain function and cognition: a brief review , 2002, Neuroscience & Biobehavioral Reviews.

[23]  A. Siddiqui,et al.  A STUDY OF THYROID HORMONES (T3, T4 & TSH) IN PATIENTS OF DEPRESSION , 2000, Indian journal of psychiatry.

[24]  C. Nemeroff,et al.  Subclinical Hypothyroidism: A Review of Neuropsychiatric Aspects , 1990, International journal of psychiatry in medicine.

[25]  P. Loosen.  The TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker , 1985, Psychoneuroendocrinology.

[26]  M. Gold,et al.  Hypothyroidism and depression. Evidence from complete thyroid function evaluation. , 1981, JAMA.

[27]  P. Linkowski,et al.  Thyrotrophin response to thyrotrophin-releasing hormone in unipolar and bipolar affective illness. , 1981, Journal of affective disorders.

[28]  D. Nandi,et al.  THYROID FUNCTION IN DIFFERENT PSYCHIATRIC DISORDERS , 1980, Indian journal of psychiatry.

[29]  F. Davidoff,et al.  Myxedema madness: psychosis as an early manifestation of hypothyroidism. , 1977, Connecticut medicine.

[30]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[31]  M. Hamilton.  The assessment of anxiety states by rating. , 1959, The British journal of medical psychology.

[32]  S. Kalra,et al.  Euthyroid depression: the role of thyroid hormone. , 2014, Recent patents on endocrine, metabolic & immune drug discovery.

[33]  R. Belmaker,et al.  Mechanisms of Disease Major Depressive Disorder , 2007 .

[34]  A. Heinz,et al.  Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain , 2002, Molecular Psychiatry.

[35]  J. Dussault,et al.  Thyroid hormones and brain development. , 1987, Annual review of physiology.

[36]  S. Bunn,et al.  Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain. , 1984, Journal of neural transmission.

[37]  R. C. Hall.  Psychiatric effects of thyroid hormone disturbance. , 1983, Psychosomatics.

[38]  M. Popkin,et al.  Psychiatric Presentations of Endocrine Dysfunction , 1980 .

[39]  P. Whybrow,et al.  Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement. , 1969, Archives of general psychiatry.