The aim of this study is to determine cancerous lesions in light microscopic and mammographic images taken from some patients. In this study, 23 features are used. These features obtained 92 features by rotating in variety of angles. Structure of the study composes three steps. These are feature select step, classification step and testing stage. In feature select step, optimal feature subset using minimum redundancy and maximum relevance via mutual information (mRMR) have been found. In classification step, Least Square Support Vector Machine (LSSVM) and fuzzy k-nearest neighbour (KNN) are used. For validation of the proposed methods accuracy rates are found. These accuracy rates, with mRMR_KNN, have obtained 100% and 98.33% in microscopic and mammographic images respectively. With mRMR_LSSVM 100% and 96.67% accuracies are obtained in microscopic and mammographic images respectively. When these microscopic and mammography images have been combined, mRMR_KNN and mRMR_LSSVM methods have found 100% and 100% accuracy rate respectively.