Functional magnetic resonance imaging of facial affect recognition in children and adolescents.

OBJECTIVE To examine further the role of the amygdala in the recognition of facial expression in adolescents. METHOD Twelve healthy adolescents were studied using functional magnetic resonance imaging technology during a task of facial affect recognition and a visual control task. RESULTS All subjects demonstrated a significant increase in signal intensity in the amygdala for the facial expression recognition task. CONCLUSIONS The data are consistent with previous work in healthy adult subjects implicating the amygdala as essential for the recognition of fearful facial expression.

[1]  M. Mesulam,et al.  Differential neural activity in the human temporal lobe evoked by faces of family members and friends , 1993, Annals of neurology.

[2]  S. Rauch,et al.  Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression , 1996, Neuron.

[3]  Hanna Damasio,et al.  Recognizing facial emotion , 1996, Nature.

[4]  R. Adolphs,et al.  Fear and the human amygdala , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[5]  C. Gordon,et al.  Childhood-onset schizophrenia: The severity of premorbid course , 1995, Biological Psychiatry.

[6]  P. Ekman.  Pictures of Facial Affect , 1976 .

[7]  Leslie G. Ungerleider.  Two cortical visual systems , 1982 .

[8]  Tim Beardsley,et al.  Shooting the Rapids , 1994 .

[9]  John P. Aggleton,et al.  The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction. , 1992 .

[10]  L. Brothers,et al.  Response of neurons in the macaque amygdala to complex social stimuli , 1990, Behavioural Brain Research.

[11]  Karen H. Calhoun,et al.  Imaging Anatomy of the Head and Spine , 1986 .

[12]  J. M. Hoffman,et al.  The functional organization of the human brain for face emotion perception: A PET neuroactivation analysis , 1996, NeuroImage.

[13]  W. Brooks,et al.  Neuropsychophysiological study of children at risk for schizophrenia: a preliminary report. , 1995, Journal of the American Academy of Child and Adolescent Psychiatry.

[14]  M. Bauman,et al.  Microscopic neuroanatomic abnormalities in autism. , 1991, Pediatrics.

[15]  Joseph E LeDoux,et al.  Emotion: Systems, Cells, Synaptic Plasticity , 1996, Cell.

[16]  Luis C. Maas,et al.  Decoupled automated rotational and translational registration for functional MRI time series data: The dart registration algorithm , 1997, Magnetic resonance in medicine.

[17]  M. Lowe,et al.  Human amygdala activation detected with echo-planar functional magnetic resonance imaging. , 1996, Neuroreport.

[18]  D. Perrett,et al.  A differential neural response in the human amygdala to fearful and happy facial expressions , 1996, Nature.

[19]  Joseph E. LeDoux,et al.  Emotion, memory and the brain. , 1994, Scientific American.

[20]  R. Adolphs,et al.  Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala , 1994, Nature.

[21]  R. Mansfield,et al.  Analysis of visual behavior , 1982 .

[22]  S. Rauch,et al.  Functional MRI and the Study of OCD: From Symptom Provocation to Cognitive-Behavioral Probes of Cortico-Striatal Systems and the Amygdala , 1996, NeuroImage.

[23]  P. Renshaw,et al.  Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. , 1996, The American journal of psychiatry.

[24]  A. Damasio.  Descartes' error: emotion, reason, and the human brain. avon books , 1994 .

[25]  James C. Ehrhardt,et al.  Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study , 1992, Biological Psychiatry.