论文信息 - Novel, regioselective allylamine construction; first synthesis of geranyllinaloisocyanide, a diterpene from the marine sponge, Halichondria sp.

Novel, regioselective allylamine construction; first synthesis of geranyllinaloisocyanide, a diterpene from the marine sponge, Halichondria sp.

The first synthesis of the diterpene, 3-isocyano-3,7,11,15-tetramethylhexadeca-1,6,10,14-tetraene (geranyllinaloisocyanide, 1), has been achieved through an allyl cyanate-to-isocyanate rearrangement. The crucial step in this synthesis is in situ transformation of allyl isocyanates into stable allyl acetamides with trimethylaluminium.

M. Isobe | Y. Ichikawa | M. Yamazaki

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