Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

[1]  K. Fung,et al.  A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders , 2017, Chinese Medicine.

[2]  Xiaowei Niu,et al.  Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction , 2018, Bioscience reports.

[3]  J. Um,et al.  Synergistic Effect of Bupleuri Radix and Scutellariae Radix on Adipogenesis and AMP-Activated Protein Kinase: A Network Pharmacological Approach , 2018, Evidence-based complementary and alternative medicine : eCAM.

[4]  Xuezhong Zhou,et al.  Prediction of Molecular Mechanisms for LianXia NingXin Formula: A Network Pharmacology Study , 2018, Front. Physiol..

[5]  M. Alagawany,et al.  Clarifying of the potential mechanism of Sinisan formula for treatment of chronic hepatitis by systems pharmacology method. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[6]  Zhiqiang Liu,et al.  Comprehensive investigation of in-vivo ingredients and action mechanism of iridoid extract from Gardeniae Fructus by liquid chromatography combined with mass spectrometry, microdialysis sampling and network pharmacology. , 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[7]  Yibin Feng,et al.  Hepatoprotective Effects of a Functional Formula of Three Chinese Medicinal Herbs: Experimental Evidence and Network Pharmacology-Based Identification of Mechanism of Action and Potential Bioactive Components , 2018, Molecules.

[8]  Yan Zhu,et al.  A new strategy for choosing “Q-markers” via network pharmacology, application to the quality control of a Chinese medical preparation , 2017, Journal of food and drug analysis.

[9]  Faruk Serin,et al.  A novel overlapped nuclei splitting algorithm for histopathological images , 2017, Comput. Methods Programs Biomed..

[10]  Yang Zhang,et al.  A Network Pharmacology Approach to Determine the Active Components and Potential Targets of Curculigo Orchioides in the Treatment of Osteoporosis , 2017, Medical science monitor : international medical journal of experimental and clinical research.

[11]  Liuting Zeng,et al.  A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids , 2017, Experimental and therapeutic medicine.

[12]  Yan Li,et al.  Systems Pharmacology Dissection of Multiscale Mechanisms of Action for Herbal Medicines in Treating Rheumatoid Arthritis. , 2017, Molecular pharmaceutics.

[13]  Fei Li,et al.  Screening Hepatotoxic Components in Euodia rutaecarpa by UHPLC-QTOF/MS Based on the Spectrum-Toxicity Relationship , 2017, Molecules.

[14]  Shu Liu,et al.  Systematically characterize the absorbed effective substances of Wutou Decoction and their metabolic pathways in rat plasma using UHPLC‐Q‐TOF‐MS combined with a target network pharmacological analysis , 2017, Journal of pharmaceutical and biomedical analysis.

[15]  Xiao Lin,et al.  Recent pharmaceutical evidence on the compatibility rationality of traditional Chinese medicine. , 2017, Journal of ethnopharmacology.

[16]  Kang Ryoung Park,et al.  Pedestrian Detection Based on Adaptive Selection of Visible Light or Far-Infrared Light Camera Image by Fuzzy Inference System and Convolutional Neural Network-Based Verification , 2017, Sensors.

[17]  Wei Li,et al.  How Can Synergism of Traditional Medicines Benefit from Network Pharmacology? , 2017, Molecules.

[18]  C. Liao,et al.  Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans , 2017, International journal of nanomedicine.

[19]  Y. Zhang,et al.  Traditional Chinese Medicine for Cardiovascular Disease: Evidence and Potential Mechanisms , 2017, Deutsche Zeitschrift für Akupunktur.

[20]  Keji Chen,et al.  Synergistic effects of Chuanxiong-Chishao herb-pair on promoting angiogenesis at network pharmacological and pharmacodynamic levels , 2017, Chinese Journal of Integrative Medicine.

[21]  Changxiao Liu,et al.  Approaches to establish Q-markers for the quality standards of traditional Chinese medicines , 2017, Acta pharmaceutica Sinica. B.

[22]  Xiaojuan He,et al.  Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation , 2017, Front. Pharmacol..

[23]  Xing Chen,et al.  A network-based method for mechanistic investigation of Shexiang Baoxin Pill’s treatment of cardiovascular diseases , 2017, Scientific Reports.

[24]  Liuting Zeng,et al.  Exploring the pharmacological mechanism of Yanghe Decoction on HER2-positive breast cancer by a network pharmacology approach. , 2017, Journal of ethnopharmacology.

[25]  Ning Wang,et al.  A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets , 2017, International journal of molecular sciences.

[26]  Haixia Chen,et al.  Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review , 2017, Front. Pharmacol..

[27]  Stephen R. Johnson,et al.  Ligand and Target Discovery by Fragment-Based Screening in Human Cells , 2017, Cell.

[28]  Yuefei Wang,et al.  Combining Chemical Profiling and Network Analysis to Investigate the Pharmacology of Complex Prescriptions in Traditional Chinese Medicine , 2017, Scientific Reports.

[29]  Yuxing Gao,et al.  Systematic Understanding of Mechanisms of a Chinese Herbal Formula in Treatment of Metabolic Syndrome by an Integrated Pharmacology Approach , 2016, International journal of molecular sciences.

[30]  Gang Bai,et al.  A rapid integrated bioactivity evaluation system based on near-infrared spectroscopy for quality control of Flos Chrysanthemi. , 2016, Journal of pharmaceutical and biomedical analysis.

[31]  Yi-Tao Chen,et al.  Identification and Verification of Potential Therapeutic Target Genes in Berberine-Treated Zucker Diabetic Fatty Rats through Bioinformatics Analysis , 2016, PloS one.

[32]  B. Yuan,et al.  How do precision medicine and system biology response to human body’s complex adaptability? , 2016, Chinese Journal of Integrative Medicine.

[33]  Cesim Erten,et al.  RedNemo: topology‐based PPI network reconstruction via repeated diffusion with neighborhood modifications , 2016, Bioinform..

[34]  T. Efferth,et al.  Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature. , 2016, Pharmacological research.

[35]  Liqun He,et al.  A system biology approach to understanding the molecular mechanisms of Gubentongluo decoction acting on IgA Nephropathy , 2016, BMC Complementary and Alternative Medicine.

[36]  Xiaorui Cheng,et al.  Effect of Liuwei Dihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network. , 2016, Pharmacology & therapeutics.

[37]  Jie Wang,et al.  Exploring mechanisms of Panax notoginseng saponins in treating coronary heart disease by integrating gene interaction network and functional enrichment analysis , 2016, Chinese Journal of Integrative Medicine.

[38]  Shao Li,et al.  Exploring traditional chinese medicine by a novel therapeutic concept of network target , 2016, Chinese Journal of Integrative Medicine.

[39]  X. Qin,et al.  Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology , 2016, Scientific Reports.

[40]  Gang Bai,et al.  Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa–induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways , 2016, Acta Pharmaceutica Sinica B.

[41]  Tieliu Shi,et al.  Deciphering the Potential Pharmaceutical Mechanism of Chinese Traditional Medicine (Gui-Zhi-Shao-Yao-Zhi-Mu) on Rheumatoid Arthritis , 2016, Scientific Reports.

[42]  S. C. Jones,et al.  Megasupramolecules for safer, cleaner fuel by end association of long telechelic polymers , 2015, Science.

[43]  Le Shi,et al.  A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout. , 2015, Journal of ethnopharmacology.

[44]  Wei Liu,et al.  Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach , 2015, Acta Pharmacologica Sinica.

[45]  Fang Feng,et al.  Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease , 2015, Evidence-based complementary and alternative medicine : eCAM.

[46]  Robert L. Barry,et al.  Breakdown of the brain’s functional network modularity with awareness , 2015, Proceedings of the National Academy of Sciences.

[47]  Hong-juan Bao,et al.  [Study on intersection and regulation mechanism of "efficacy-toxicity network" of aconite in combination environment of Sini decoction]. , 2015, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[48]  Xiang Zhang,et al.  Drug repositioning by integrating target information through a heterogeneous network model , 2014, Bioinform..

[49]  Jian Du,et al.  Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. , 2014, European journal of medicinal chemistry.

[50]  S. Chan,et al.  A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect , 2014, BioMed research international.

[51]  Xiang Li,et al.  Dissecting active ingredients of Chinese medicine by content-weighted ingredient-target network. , 2014, Molecular bioSystems.

[52]  Shao Li,et al.  A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study. , 2014, Molecular bioSystems.

[53]  Bo Zhang,et al.  Traditional Chinese medicine network pharmacology: theory, methodology and application: Traditional Chinese medicine network pharmacology: theory, methodology and application , 2014 .

[54]  Dongsheng Cao,et al.  A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease , 2014, PloS one.

[55]  L. An,et al.  Hippocampus and serum metabolomic studies to explore the regulation of Chaihu-Shu-Gan-San on metabolic network disturbances of rats exposed to chronic variable stress. , 2014, Molecular bioSystems.

[56]  Yonghua Wang,et al.  Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction. , 2013, Journal of ethnopharmacology.

[57]  Jing Zhao,et al.  Bioinformatics Analysis for the Antirheumatic Effects of Huang-Lian-Jie-Du-Tang from a Network Perspective , 2013, Evidence-based complementary and alternative medicine : eCAM.

[58]  Bingxin Lu,et al.  Evaluating the Pharmacological Mechanism of Chinese Medicine Si-Wu-Tang through Multi-Level Data Integration , 2013, PloS one.

[59]  Wan-ying Wu,et al.  Pharmacological tools for the development of traditional Chinese medicine. , 2013, Trends in pharmacological sciences.

[60]  Wiley M. Kitchens,et al.  Network modularity reveals critical scales for connectivity in ecology and evolution , 2013, Nature Communications.

[61]  A. Zhang,et al.  Ultraperformance liquid chromatography-mass spectrometry based comprehensive metabolomics combined with pattern recognition and network analysis methods for characterization of metabolites and metabolic pathways from biological data sets. , 2013, Analytical chemistry.

[62]  Chunjie Wu,et al.  Bioactivities and serum pharmacochemistry of Qi-Wei-Xiao-Yan-Tang , 2013, Pharmaceutical biology.

[63]  Bo Zhang,et al.  An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula, Qing-Luo-Yin , 2013, Evidence-based complementary and alternative medicine : eCAM.

[64]  D. Borsboom,et al.  Network analysis: an integrative approach to the structure of psychopathology. , 2013, Annual review of clinical psychology.

[65]  Shao Li,et al.  Traditional Chinese medicine network pharmacology: theory, methodology and application. , 2013, Chinese journal of natural medicines.

[66]  Aiping Lu,et al.  Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery , 2012, Evidence-based complementary and alternative medicine : eCAM.

[67]  Samiul Hasan,et al.  Network analysis has diverse roles in drug discovery. , 2012, Drug discovery today.

[68]  Shiwen Zhao,et al.  A co-module approach for elucidating drug-disease associations and revealing their molecular basis , 2012, Bioinform..

[69]  R. Iyengar,et al.  Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. , 2012, Annual review of pharmacology and toxicology.

[70]  Yi Wang,et al.  [Tools for network pharmacology study: network visualization and network analysis]. , 2011, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[71]  Chun-song Zheng,et al.  Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall on osteoarthritis disease: A computational pharmacology approach , 2011, Chinese journal of integrative medicine.

[72]  Rodolfo Dirzo,et al.  Analysis of a hyper-diverse seed dispersal network: modularity and underlying mechanisms. , 2011, Ecology letters.

[73]  Hong-Qin Yang,et al.  [Chemical proteomics and discovery of drug targets]. , 2011, Yao xue xue bao = Acta pharmaceutica Sinica.

[74]  P. Bork,et al.  Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity , 2011, PloS one.

[75]  Bo Zhang,et al.  Network target for screening synergistic drug combinations with application to traditional Chinese medicine , 2011, BMC Systems Biology.

[76]  Xiaowen Chen,et al.  Topological properties of the drug targets regulated by microRNA in human protein–protein interaction network , 2011, Journal of drug targeting.

[77]  Masanori Arita,et al.  Metabolomic correlation-network modules in Arabidopsis based on a graph-clustering approach , 2011, BMC Systems Biology.

[78]  Peng Jiang,et al.  Molecular networks for the study of TCM Pharmacology , 2010, Briefings Bioinform..

[79]  Kai Huang,et al.  PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach , 2010, Nucleic Acids Res..

[80]  A. Hopkins.  Network pharmacology: the next paradigm in drug discovery. , 2008, Nature chemical biology.

[81]  Chris H Wiggins,et al.  Bayesian approach to network modularity. , 2007, Physical review letters.

[82]  P. Y. Ng,et al.  Genetic studies of diseases , 2007, Cellular and Molecular Life Sciences.

[83]  W Xu,et al.  Traditional Chinese medicine in cancer care: perspectives and experiences of patients and professionals in China. , 2006, European journal of cancer care.

[84]  T. Vicsek,et al.  Uncovering the overlapping community structure of complex networks in nature and society , 2005, Nature.

[85]  Igor Jurisica,et al.  Protein complex prediction via cost-based clustering , 2004, Bioinform..

[86]  Gary D Bader,et al.  BMC Bioinformatics Methodology article Statistical significance for hierarchical clustering in genetic association and microarray expression studies , 2003 .

[87]  N. Farnsworth,et al.  The value of plants used in traditional medicine for drug discovery. , 2001, Environmental health perspectives.

[88]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .

[89]  J. V. Ness,et al.  Space-conserving agglomerative algorithms , 1996 .

[90]  Jiansong Fang,et al.  Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease. , 2018, Chinese journal of natural medicines.

[91]  Wen-bin Hou,et al.  A New Concept on Quality Marker for Quality Assessment and Process Control of Chinese Medicines , 2017 .

[92]  R. Tao,et al.  Traditional Chinese Medicine (TCM) Therapy. , 2017, Advances in experimental medicine and biology.

[93]  Chunping Tang,et al.  TCM, brain function and drug space. , 2016, Natural product reports.

[94]  L. Shan,et al.  "Omics" in pharmaceutical research: overview, applications, challenges, and future perspectives. , 2015, Chinese journal of natural medicines.

[95]  A. Hopkins.  Network pharmacology , 2007, Nature Biotechnology.

[96]  R. Tardiff.  In vitro methods of toxicity evaluation. , 1978, Annual review of pharmacology and toxicology.