Cryoprecipitation of fibrin-fibrinogen complexes induced by the cold-insoluble globulin of plasma.

A cold-insoluble precipitate that formed from normal plasma treated with small amounts of thrombin was comprised of three mai n components: cold-insoluble globulin (CIg), fibrin, and fibrinogen. Its composition appeared to be the same as that of a pathologic plasma precipitate termed “cryofibrinogen.” We examined the roles played by each of these components in generating such a precipitate. Fibrinogen from a preparation containing a high proportion of molecules with intact Aa chains (fraction 1-4) was coupled to Sepharose 4B; columns of this material were compared before and after conversion to fibrin with respect to their CIg binding capacity. Fibrinogen columns displayed significant CIg binding at 4’C but very little at 22’C; fibrin columns bound significant quantities of CIg at both temperatures. Under standardized condi

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