Antimicrobial secondary metabolite-producing potential of streptomyces sp. isolated from soil

A total of 150 strains of actinomycetes were isolated from different soil samples collected from various locations of Patna (Bihar). The actinomycetes strains were screened for their antimicrobial potential against test organisms such as Escherichia coli MTCC 739, Staphylococcus aureus MTCC 96, Streptomyces lividans TK 23 MTCC 4, and Candida albicans MTCC 227 by cross-streak method. The bioassay revealed that about 53.33% of actinomycetes isolates were active against test organisms. Characterization of these isolates has led to identification of unique strains of Streptomyces (MP 562 and NP 302) showing broad spectrum of antimicrobial properties. On the basis of λmax values of culture filtrates, it has been suggested that these strains might be producing LL-E19085 and lipopeptide LY146032 like antibacterial and a flavone glycoside like antifungal antibiotics.

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